Abstract:To the Editor: Switching to an antidepressant in a different pharmacologic class, which is often employed in clinical practice for major depressive disorder (MDD) patients who have not responded sufficiently to an initial antidepressant, usually yields better clinical outcome. However, some randomized controlled trials (RCTs) and RCT-based meta-analyses designed to test the efficacy of switching therapies suggest that switching to another antidepressant may not be superior to continuing the initial antidepress… Show more
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