The G92 NS2B mutant of Tembusu virus is involved in severe defects in progeny virus assembly

Wu, Zaohe; Hu, Tao; Chen, Weiqiong; Cheng, Yao; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Huang, Juan; Mao, Sai; Ou, Xumin; Gao, Qun; Sun, Di; Cheng, Anchun; Chen, Shun

doi:10.1016/j.vetmic.2022.109396

Cited by 1 publication

(1 citation statement)

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“…The mutations D25A, A43Y, V44A, G92A, and P112A led to minor defects in virus replication. Only the G92A mutation affected virus proliferation by blocking virus release, without affecting viral RNA synthesis, indicating the involvement of G92 in the assembly of infectious TMUV particles [70].…”

Section: Non-structural Proteinsmentioning

confidence: 96%

Advancements in Research on Duck Tembusu Virus Infections

Cheng,

Wang,

et al. 2024

Viruses

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Duck Tembusu Virus (DTMUV) is a pathogen of the Flaviviridae family that causes infections in poultry, leading to significant economic losses in the duck farming industry in recent years. Ducks infected with this virus exhibit clinical symptoms such as decreased egg production and neurological disorders, along with serious consequences such as ovarian hemorrhage, organ enlargement, and necrosis. Variations in morbidity and mortality rates exist across different age groups of ducks. It is worth noting that DTMUV is not limited to ducks alone; it can also spread to other poultry such as chickens and geese, and antibodies related to DTMUV have even been found in duck farm workers, suggesting a potential risk of zoonotic transmission. This article provides a detailed overview of DTMUV research, delving into its genomic characteristics, vaccines, and the interplay with host immune responses. These in-depth research findings contribute to a more comprehensive understanding of the virus’s transmission mechanism and pathogenic process, offering crucial scientific support for epidemic prevention and control.

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Section: Non-structural Proteinsmentioning

confidence: 96%