The G3057A LEPR polymorphism is associated with obesity in Tunisian women

Ali, Samir Ben; Sediri, Yousra; Kallel, Amani; Ftouhi, B.; Haj-Taib, S.; Omar, Souheil; Sanhaji, Haïfa; Feki, Moncef; Elasmi, Monia; Slimène, H.; Jemaa, Riadh; Kaabachi, Naziha

doi:10.1016/j.numecd.2009.12.011

Cited by 7 publications

(8 citation statements)

References 21 publications

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“…The literature search identified 62 articles that reported associations between adipokine‐related genetic polymorphisms and obesity. A flow diagram of the study identification process is shown in (8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69). Fourteen of these studies were excluded (56,57,58,59,60,61,62,63,64,65,66,67,68,69), 10 of which were due to the study population being specific, selected and not representative, such as obesity with type 2 diabetes (56,58), obesity with insulin resistance (57,68), obese children (59,60,61), obese women (62,63), and obese men (69).…”

Section: Resultsmentioning

confidence: 99%

“…Four studies were excluded because adipokine‐related genetic polymorphisms or genotype frequencies were not reported (64,65,66,67). Forty‐five studies were included in the meta‐analysis () (8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52), and three studies were included in the systematic review (53,54,55). Twenty‐one polymorphisms in seven genes were assessed in the included studies.…”

Section: Resultsmentioning

confidence: 99%

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Genetic Polymorphisms in Adipokine Genes and the Risk of Obesity: A Systematic Review and Meta‐Analysis

Han

Cao

et al. 2012

Obesity

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Polymorphisms in adipokine genes, such as leptin (LEP), leptin receptor (LEPR), resistin (RETN), adiponectin (ADIPOQ), interleukin‐1β (IL‐1β), IL‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) may be involved in the development of obesity. We conducted a systematic review of published evidence on the association between different adipokine genes and the risk of obesity. Librarian‐designed searches of PubMed and HuGeNet, review of reference lists from published reviews and content expert advice identified potentially eligible studies. The genotyping information and polymorphisms of different adipokine genes, numbers of genotyped cases and controls and frequencies of genotypes were extracted from 48 eligible studies included in this review. Twenty‐one polymorphisms each associated with obesity in at least one study were identified. Polymorphisms in the adipokine genes, LEP, LEPR, and RETN were not associated with obesity susceptibility, whereas ADIPOQ G276T (T vs. G: odds ratio (OR), 1.59; 95% confidence interval (CI), 1.39–1.81), IL‐1β C3953T (CC vs. CT+TT: OR, 1.61; 95% CI, 1.18–2.20), and TNF‐α G308A (GG vs. GA+AA: OR, 1.19; 95% CI, 1.02–1.39) polymorphisms were associated with an increased risk of obesity. The IL‐6 G174C polymorphism was also associated obesity when using allelic comparisons, the recessive genetic model and the dominant genetic model with OR (95% CI) of 1.95 (1.37–2.77), 1.44 (1.15–1.80), and 1.36 (1.16–1.59), respectively. No significant evidence of publication bias was present. However, these “null” results were underpowered due to a small pooled sample size, and analysis of additional case‐control studies with larger sample sizes should provide further clarifications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Genetic Polymorphisms in Adipokine Genes and the Risk of Obesity: A Systematic Review and Meta‐Analysis

Han

Cao

et al. 2012

Obesity

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“…A study of leptin level in GHD patients showed significantly depressed secretion [ 18 ]. The expression level of leptin was affected by gene polymorphism [ 19 – 21 ], suggesting the correlation between GHD pathogenesis and gene polymorphism of leptin and leptin receptor genes.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Gene Polymorphism of Leptin and Leptin Receptor and Growth Hormone Deficiency

Fang

Lin

et al. 2016

Med Sci Monit

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BackgroundsGrowth hormone deficiency (GHD) is a major cause of congenital short stature. GHD patients have significantly decreased serum leptin levels, which are regulated by gene polymorphism of leptin and leptin receptor. This study thus investigated the relationship between gene polymorphism and susceptibility to GHD.Material/MethodsA case-control study was performed using 180 GHD children in addition to 160 healthy controls. After the extraction of whole genomic DNA, the genotypes of leptin and leptin receptor gene loci were analyzed by sequencing for single-nucleotide polymorphism.ResultsThe frequency distribution of all alleles identified in leptin gene (loci rs7799039) and leptin receptor gene (loci rs1137100 and rs1137101) fit Hardy-Weinberg equilibrium. There was a significant difference in allele frequency at loci rs7799039 or rs1137101, as individuals with heterozygous GA allele had lower (rs7799039) or higher (rs1137101) GHD risk. No significant difference in allele frequency was discovered at loci rs1137100 (p>0.05), which was unrelated to GHD susceptibility.ConclusionsGene polymorphism of leptin (loci rs7799039) and leptin receptor (loci rs1137101) are correlated with GHD susceptibility.

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“…SNP may be responsible for individual differences in drug response, and complex and common diseases such as obesity, diabetes, hypertension, and psychiatric disorders 18 . Recently, several studies were reported associations between polymorphisms of various genes and obesity such as leptin receptor (LEPR) 19 , toll-like receptor 4 (TLR4) 20 , and fat mass and obesity associated (FTO) 21 . Ben et al 19 reported that LEPR polymorphism (G3057A) was risk factor for obesity.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several studies were reported associations between polymorphisms of various genes and obesity such as leptin receptor (LEPR) 19 , toll-like receptor 4 (TLR4) 20 , and fat mass and obesity associated (FTO) 21 . Ben et al 19 reported that LEPR polymorphism (G3057A) was risk factor for obesity. Jermendy et al 20 showed the association between TLR4 polymorphisms and serum cytokine levels in obese children.…”

Section: Discussionmentioning

confidence: 99%

Association of Niemann-Pick disease, type C2 (NPC2) polymorphisms with obesity in Korean population

Kim

Lee

Park

et al. 2010

Mol. Cell. Toxicol.

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Cholesterol homeostasis is essential for functional integrity of lipid. Niemann-Pick disease, type C2 (NPC2) encodes a protein containing a lipid recognition domain. NPC2 is related to regulation of cholesterol and other lipids. To evaluate NPC2 gene and its correlation to obesity in Korean population, 214 overweight/obese and 160 healthy control subjects were enrolled in this study. Genomic DNA was extracted from peripheral blood. Two tag single nucleotide polymorphisms (tag SNPs) in NPC2 gene were selected (rs8008540 and rs917394). Genotypes were determined using direct sequencing. For the analysis of genetic data, Helixtree software, SNPAnalyzer, SNPStats, and Haploview version 4.2 were used. Multiple logistic regression models (codominant, dominant, and recessive models) were performed for odds ratio (OR), 95% confidence interval (CI), and P value. In allele distribution analysis, allele of rs917394 was associated with obesity (OR=1.45, 95% CI=1.08-1.95, P=0.014). The genotype distributions of tag SNPs (rs8008540 and rs917394) were showed significant differences between overweight/obese and control subjects [rs8008540, OR=1.63, 95% CI=1.04-2.58, P=0.034 in codominant 1 (C/C versus C/T) model, OR=1.58, 95% CI=1. 03-2.44, P=0.036 in dominant model; rs917394, OR=2.33, 95% CI=1.20-4.52, P= 0.013 in codominant model 2 (T/T versus C/C), OR= 1.62, 95% CI=1.05-2.52, P=0.030 in dominant model]. Haplotype (CT) was also associated with overweight/obese (frequency=0.589, chi square=6.100, P=0.014). These results indicate that NPC2 gene may be associated with obesity in Korean population.

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The G3057A LEPR polymorphism is associated with obesity in Tunisian women

Cited by 7 publications

References 21 publications

Genetic Polymorphisms in Adipokine Genes and the Risk of Obesity: A Systematic Review and Meta‐Analysis

Genetic Polymorphisms in Adipokine Genes and the Risk of Obesity: A Systematic Review and Meta‐Analysis

The Relationship Between Gene Polymorphism of Leptin and Leptin Receptor and Growth Hormone Deficiency

Association of Niemann-Pick disease, type C2 (NPC2) polymorphisms with obesity in Korean population

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