The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain

Collins, Lila R.; Ricketts, William; Olefsky, Jerrold M.; Brown, Joan Heller

doi:10.1038/sj.onc.1201220

Cited by 33 publications

(19 citation statements)

References 23 publications

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“…It is likely that they stimulate speci®c guanine nucleotide exchange factors (GEFs), compete with guanine nucleotide dissociation inhibitors (GDIs), or inhibit speci®c GAPs (Dhanasekaran and Dermott, 1996). A role for tyrsosine phosphorylation of Shc in the signal coupling between Ga 12 and Ras has been proposed in thrombinstimulated Ga 12 -mediated mitogenic pathway of astrocytoma cells (Collins et al, 1997). A recent observation that LPA receptors can activate Tiam-1, an exchange factor for Rac through a PKC-dependent mechanism (Fleming et al, 1997), suggests an interesting possibility that Ga 12 , which activates PKC-dependent pathway in some cell types, can stimulate Rac and possibly Rac-mediated JNK activity through PKC and Tiam-1.…”

Section: Ga 12/13 : the Gep Oncogenes?mentioning

confidence: 99%

Regulation of cell proliferation by G proteins

Dhanasekaran

Tsim²,

Dermott³

et al. 1998

Oncogene

136

107

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G Proteins provide signal transduction mechanisms to seven transmembrane receptors. Recent studies have indicated that the a-subunits as well as the bg-subunits of these proteins regulate several critical signaling pathways involved in cell proliferation, di erentiation and apoptosis. Of the 17 a-subunits that have been cloned, at least ten of them have been shown to couple mitogenic signaling in ®broblast cells. Activating mutations in Ga s , Ga i2 , and Ga 12 have been correlated with di erent types of tumors. In addition, the ability of the bg-subunits to activate mitogenic pathways in di erent cell-types has been de®ned. The present review brie¯y summarizes the diverse and novel signaling pathways regulated by the a-as well as the bg-subunits of G proteins in regulating cell proliferation.

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Section: Ga 12/13 : the Gep Oncogenes?mentioning

confidence: 99%

Regulation of cell proliferation by G proteins

Dhanasekaran

Tsim²,

Dermott³

et al. 1998

Oncogene

136

107

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“…Gβγ subunit activates phosphatidylinositol 3-kinase, phospholipase Cβ, non-receptor tyrosine kinase pp60 src , and G proteincoupled receptor kinase (20, 54). Thrombin-induced activation of pp60 src (55) causes activation of the mitogenactivated protein kinase cascade via Shc-Grb2 complex (56)(57)(58). The thrombin-induced activation of mitogen-activated protein kinase was either sensitive (59) or insensitive (57) to pertussis toxin.…”

Section: Intracellular Signal Transduction Pathways Following Activatmentioning

confidence: 99%

Role of Protease-activated Receptors in the Vascular System

Hirano

Kobayashi

2003

JAT

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“…The Ga 12/13 subfamily has been implicated in a number of cellular functions, including Rho-dependent cytoskeletal shape changes, activation of c-Jun Nterminal kinase, and stimulation of Na + /H + exchange (Dhanasekaran and Dermott, 1996;Lin et al, 1996;Collins et al, 1997;Voyno-Yasenetskaya et al, 1996;Gohla et al, 1999). In addition, there is substantial evidence that Ga 12/13 proteins mediate signaling pathways involved in cell growth and tumorigenesis (Chan et al, 1993;Jiang et al, 1993;Jones and Gutkind, 1998;Dermott et al, 1999).…”

mentioning

confidence: 99%