The G protein‐coupled estrogen receptor of the trigeminal ganglion regulates acute and chronic itch in mice

Li, Jun; Gao, Po; Zhang, Siyu; Lin, Xiaoqi; Chen, Junhui; Zhang, Song; Jiao, Yingfu; Yu, Weifeng; Xia, Xiaoqiong; Yang, Liqun

doi:10.1111/cns.14367

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…Overall, although itch has been scientifically recognized for 360 years, we have only begun to gradually understand its underlying mechanisms in the last 20 years. Itch and neuroimmunology research has identified potential mechanisms in terms of nerve transmission, 57 immune cells, 15 and inflammatory factors, 16 which provide the basis for biologically targeted agents to treat pruritic diseases. However, various research directions still deserve further exploration and focus.…”

Section: Discussionmentioning

confidence: 99%

Emerging trends and hotspots of the itch research: A bibliometric and visualized analysis

Li,

Wang,

Yin

et al. 2023

CNS Neurosci Ther

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AimsItch, a common uncomfortable sensory experience, occurs frequently in inflammatory or allergic disorders. In recent years, with the discovery of itch‐specific pathways in the peripheral and central nervous system, the association between immunology and neural pathways has gradually emerged as the main mechanism of itch. Although many studies have been conducted on itch, no bibliometric analysis study focusing on this topic has been conducted. This study aimed to explore the research hotspots and trends in the itch field from a bibliometric perspective.MethodsPublications relevant to itch, published from 2003 to 2022, were retrieved from the Science Citation Index‐Expanded of Web of Science Core Collection. Publications were critically reviewed and analyzed with CiteSpace software, Vosviewer, and the bibliometric online analysis platform. Visual maps were conducted in terms of annual production, collaborating countries or institutions, productive authors, core journals, co‐cited references, and keyword bursts.Results2395 articles on itch that met our criteria were identified and the quantity of publications has been increasing rapidly since 2012. The USA was the most influential country. University Hospital Münster was the institution with the most publications. Gil Yosipovitch was the most prolific author. Atopic dermatitis (AD), intradermal serotonin, chronic pruritus, mechanical itch, gastrin‐releasing peptide, substance p, interleukin‐31 receptor, histamine‐induced itch, bile acid, scratching behavior, and h‐4 receptor were the top 11 clusters in co‐citation cluster analysis. Keyword burst analysis suggested that treatment, inflammation, and AD are current research hotspots.ConclusionGlobal publications on itch research have increased steadily and rapidly over the past 20 years. Inflammation and AD are current research hotspots. The neuroimmunological and neuroinflammatory mechanisms of itch, as well as clinical assessment methods and therapeutic targets, will be novel research directions in the future. This study provides guidance for further itch research.

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Section: Discussionmentioning

confidence: 99%

Emerging trends and hotspots of the itch research: A bibliometric and visualized analysis

Li,

Wang,

Yin

et al. 2023

CNS Neurosci Ther

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GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain via mediating descending facilitation

Chen,

Wu,

Xie

et al. 2024

Preprint

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Neuropathic pain, a major health problem affecting 7 - 10% of the global population, lacks effective treatment due to its elusive mechanisms. Cholecystokinin-positive (CCK+) neurons in the spinal dorsal horn (SDH) are critical for neuropathic pain, yet the underlying molecular mechanisms remain unclear. Here we showed that the membrane estrogen receptor G-protein coupled estrogen receptor (GPER/GPR30) in spinal was significantly upregulated in chronic constriction injury (CCI) mice and that inhibition of GPR30 in CCK+ neurons reversed CCI-induced neuropathic pain. Besides, GPR30 in spinal CCK+ neurons was essential for the enhancement of AMPA-mediated excitatory synaptic transmission in CCI mice. Furthermore, GPR30 was expressed in the spinal CCK+ neurons receiving direct projection from the primary sensory cortex (S1-SDH). Chemogenetic inhibition of S1-SDH post-synaptic neurons alleviated CCI-induced neuropathic pain. Conversely, chemogenetic activation of these neurons mimicked neuropathic pain symptoms, which were attenuated by spinal inhibition of GPR30. Finally, we confirmed that GPR30 in S1-SDH post-synaptic neurons is required for CCI-induced neuropathic pain. Taken together, our findings suggest that GPR30 in spinal CCK+ neurons is pivotal for neuropathic pain and mediates descending facilitation by corticospinal direct projections, thereby representing a promising therapeutic target for neuropathic pain.

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The G protein‐coupled estrogen receptor of the trigeminal ganglion regulates acute and chronic itch in mice

Cited by 2 publications

References 62 publications

Emerging trends and hotspots of the itch research: A bibliometric and visualized analysis

Emerging trends and hotspots of the itch research: A bibliometric and visualized analysis

GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain via mediating descending facilitation

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