The future of phage biocontrol in integrated plant protection for sustainable crop production

Holtappels, Dominique; Fortuna, Kiandro; Lavigne, Rob; Wagemans, Jeroen

doi:10.1016/j.copbio.2020.08.016

Cited by 96 publications

(94 citation statements)

References 64 publications

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“…Bacteriophages, or phages, are emerging as a new trait in biocontrol, replacing or accompanying bacterial biocontrol agents [ 109 , 110 ]. Phage interactions are typical for a root microbiome [ 111 ], which suggests phages could be useful tools in biocontrol.…”

Section: How To Identify New Potent Microbial Traitsmentioning

confidence: 99%

“…Phage interactions are typical for a root microbiome [ 111 ], which suggests phages could be useful tools in biocontrol. For a successful tailored product, life cycle and host interactions of the pathogen need to be thoroughly understood [ 110 ]. The antimicrobial mechanisms are based on lysis of bacterial cells caused by virulent phages or lytic enzymes.…”

Section: How To Identify New Potent Microbial Traitsmentioning

confidence: 99%

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Biofertilizers and Biocontrol Agents for Agriculture: How to Identify and Develop New Potent Microbial Strains and Traits

et al. 2021

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Microbiological tools, biofertilizers, and biocontrol agents, which are bacteria and fungi capable of providing beneficial outcomes in crop plant growth and health, have been developed for several decades. Currently we have a selection of strains available as products for agriculture, predominantly based on plant-growth-promoting rhizobacteria (PGPR), soil, epiphytic, and mycorrhizal fungi, each having specific challenges in their production and use, with the main one being inconsistency of field performance. With the growing global concern about pollution, greenhouse gas accumulation, and increased need for plant-based foods, the demand for biofertilizers and biocontrol agents is expected to grow. What are the prospects of finding solutions to the challenges on existing tools? The inconsistent field performance could be overcome by using combinations of several different types of microbial strains, consisting various members of the full plant microbiome. However, a thorough understanding of each microbiological tool, microbial communities, and their mechanisms of action must precede the product development. In this review, we offer a brief overview of the available tools and consider various techniques and approaches that can produce information on new beneficial traits in biofertilizer and biocontrol strains. We also discuss innovative ideas on how and where to identify efficient new members for the biofertilizer and biocontrol strain family.

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Section: How To Identify New Potent Microbial Traitsmentioning

confidence: 99%

Section: How To Identify New Potent Microbial Traitsmentioning

confidence: 99%

Biofertilizers and Biocontrol Agents for Agriculture: How to Identify and Develop New Potent Microbial Strains and Traits

et al. 2021

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“…Additionally, phage cocktails have been employed against Ralstonia solanacearum in bananas [227]. Several recent reviews have covered advancements and future prospective of using bacteriophages for the management of bacterial plant diseases [221,[228][229][230][231]. In addition, the feasibility of bacteriophages to be used in aquaculture settings continues to be increasingly investigated, in both prophylactic and therapeutic approaches [232][233][234].…”

Section: Bacteriophage As a Biocontrol Tool To Enhance Food Safetymentioning

confidence: 99%

The Age of Phage: Friend or Foe in the New Dawn of Therapeutic and Biocontrol Applications?

et al. 2021

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Extended overuse and misuse of antibiotics and other antibacterial agents has resulted in an antimicrobial resistance crisis. Bacteriophages, viruses that infect bacteria, have emerged as a legitimate alternative antibacterial agent with a wide scope of applications which continue to be discovered and refined. However, the potential of some bacteriophages to aid in the acquisition, maintenance, and dissemination of negatively associated bacterial genes, including resistance and virulence genes, through transduction is of concern and requires deeper understanding in order to be properly addressed. In particular, their ability to interact with mobile genetic elements such as plasmids, genomic islands, and integrative conjugative elements (ICEs) enables bacteriophages to contribute greatly to bacterial evolution. Nonetheless, bacteriophages have the potential to be used as therapeutic and biocontrol agents within medical, agricultural, and food processing settings, against bacteria in both planktonic and biofilm environments. Additionally, bacteriophages have been deployed in developing rapid, sensitive, and specific biosensors for various bacterial targets. Intriguingly, their bioengineering capabilities show great promise in improving their adaptability and effectiveness as biocontrol and detection tools. This review aims to provide a balanced perspective on bacteriophages by outlining advantages, challenges, and future steps needed in order to boost their therapeutic and biocontrol potential, while also providing insight on their potential role in contributing to bacterial evolution and survival.

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“…Meanwhile, there has been great interest in developing novel sterilizing methods, such as "self-disinfecting" surfaces, continuous room disinfection with diluted chemical sterilant, and other reagents (Weber et al, 2019). Among these, the potential of phages in environmental disinfection has been long neglected but is now being applied in food processing workshops, livestock farms, and croplands (Holtappels et al, 2020;Pinto et al, 2020;Żbikowska et al, 2020). Phage disinfectants possess multiple advantages over conventional ones: first, phages are a very abundant microbial resource that holds great promise and options for targeting problematic bacteria such as those with multiple AMR or biofilm formation properties.…”

Section: Phage Disinfection For Nosocomial Transmission Controlmentioning

confidence: 99%

“…However, little has been described regarding the systemic application of phages in infection management. Nevertheless, a similar concept has been successfully practiced in several other settings (e.g., food, animals, crops) (Holtappels et al, 2020;Pinto et al, 2020;Żbikowska et al, 2020), where a few phage-based products have been approved by the supervisory authorities in the United States, Canada, Israel, Europe, Australia and New Zealand (Pinto et al, 2020).…”

Section: A Practical Model Of Using Phage In Nosocomial Infection Managementmentioning

confidence: 99%

Potential of Therapeutic Bacteriophages in Nosocomial Infection Management

Zhu

2021

Front. Microbiol.

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Nosocomial infections (NIs) are hospital-acquired infections which pose a high healthcare burden worldwide. The impact of NIs is further aggravated by the global spread of antimicrobial resistance (AMR). Conventional treatment and disinfection agents are often insufficient to catch up with the increasing AMR and tolerance of the pathogenic bacteria. This has resulted in a need for alternative approaches and raised new interest in therapeutic bacteriophages (phages). In contrast to the limited clinical options available against AMR bacteria, the extreme abundance and biodiversity of phages in nature provides an opportunity to establish an ever-expanding phage library that collectively provides sustained broad-spectrum and poly microbial coverage. Given the specificity of phage-host interactions, phage susceptibility testing can serve as a rapid and cost-effective method for bacterial subtyping. The library can also provide a database for routine monitoring of nosocomial infections as a prelude to preparing ready-to-use phages for patient treatment and environmental sterilization. Despite the remaining obstacles for clinical application of phages, the establishment of phage libraries, pre-stocked phage vials prepared to good manufacturing practice (GMP) standards, and pre-optimized phage screening technology will facilitate efforts to make phages available as modern medicine. This may provide the breakthrough needed to demonstrate the great potential in nosocomial infection management.

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The future of phage biocontrol in integrated plant protection for sustainable crop production

Cited by 96 publications

References 64 publications

Biofertilizers and Biocontrol Agents for Agriculture: How to Identify and Develop New Potent Microbial Strains and Traits

Biofertilizers and Biocontrol Agents for Agriculture: How to Identify and Develop New Potent Microbial Strains and Traits

The Age of Phage: Friend or Foe in the New Dawn of Therapeutic and Biocontrol Applications?

Potential of Therapeutic Bacteriophages in Nosocomial Infection Management

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