The future of neuroimaging and gut-brain axis research for substance use disorders

Colon-Perez, Luis M.; Montesinos, J. Seguí; Monsivais, Mildred

doi:10.1016/j.brainres.2022.147835

Cited by 8 publications

(3 citation statements)

References 163 publications

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“…Additionally, restrictive bariatric procedures modify the gut microbiota, its composition and circulating metabolites from intestinal bacteria [ 44 ]. Alterations in the gut microbiota can directly influence gut–brain communication and, consequently, the reward and stress response with a risk of OUD development [ 45 , 46 ]. It has already been shown that chronic morphine use can cause bacterial translocation across the gut wall and induce inflammation, which regulates brain function and, thus, may affect opioid addiction risk [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

“…After surgery, the gut peptides and bile acid metabolism are changed, which results in altered gut–brain axis communication. Even opioid drugs appear to influence the bacterial flora [ 46 ]. These effects are becoming essential to consider when evaluating (food) cravings, depression, satiety, self-esteem and, thus, their role in OUD [ 71 , 72 , 73 , 74 , 75 , 76 ].…”

Section: Discussionmentioning

confidence: 99%

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Opioid Analgesics after Bariatric Surgery: A Scoping Review to Evaluate Physiological Risk Factors for Opioid-Related Harm

Wuyts

Torensma

Schellekens

et al. 2023

JCM

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The persisting use of opioids following bariatric surgery has emerged as a prevalent complication, heightening the probability of opioid-related harm (ORM), such as opioid-related fatalities and prescription opioid use disorder (OUD). A comprehensive review of PubMed literature from 1990 to 2023 was conducted to pinpoint physiological influences on postoperative ORM. As a result, we found that patients undertaking bariatric operations often exhibit an inherently higher risk for substance use disorders, likely attributable to genetic predisposition and related neurobiological changes that engender obesity and addiction-like tendencies. Furthermore, chronic pain is a common post-bariatric surgery complaint, and the surgical type impacts opioid needs, with increased long-term opioid use after surgeries. Additionally, the subjective nature of pain perception in patients with obesity can distort pain reporting and the corresponding opioid prescription both before and after surgery. Furthermore, the postoperative alterations to the gastrointestinal structure can affect the microbiome and opioid absorption rates, resulting in fluctuating systemic exposure to orally ingested opioids. The prospect of ORM development post-bariatric surgery appears amplified due to a preexisting susceptibility to addictive habits, surgically induced pain, modified gut–brain interaction and pain management and the changed pharmacokinetics post-surgery. Further research is warranted to clarify these potential risk variables for ORM, specifically OUD, in the bariatric population.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Opioid Analgesics after Bariatric Surgery: A Scoping Review to Evaluate Physiological Risk Factors for Opioid-Related Harm

Wuyts

Torensma

Schellekens

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…Multiple intertwined genetic, psychosocial, and neuro-immuno-endocrine factors have been proposed to contribute to the association of obesity and SUD, including the gut–brain axis, inflammation and oxidative stress [ 40 , 41 , 42 , 43 , 44 ]. In particular, much evidence shows that overweight and obesity are associated with alterations in oxidative stress and mitochondrial functions in peripheral organs and in the brain [ 45 , 46 , 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Neurobiological Mechanisms Modulating Emotionality, Cognition and Reward-Related Behaviour in High-Fat Diet-Fed Rodents

Ziemens

Touma

Rappeneau

2022

IJMS

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Affective and substance-use disorders are associated with overweight and obesity-related complications, which are often due to the overconsumption of palatable food. Both high-fat diets (HFDs) and psychostimulant drugs modulate the neuro-circuitry regulating emotional processing and metabolic functions. However, it is not known how they interact at the behavioural level, and whether they lead to overlapping changes in neurobiological endpoints. In this literature review, we describe the impact of HFDs on emotionality, cognition, and reward-related behaviour in rodents. We also outline the effects of HFD on brain metabolism and plasticity involving mitochondria. Moreover, the possible overlap of the neurobiological mechanisms produced by HFDs and psychostimulants is discussed. Our in-depth analysis of published results revealed that HFDs have a clear impact on behaviour and underlying brain processes, which are largely dependent on the developmental period. However, apart from the studies investigating maternal exposure to HFDs, most of the published results involve only male rodents. Future research should also examine the biological impact of HFDs in female rodenrts. Further knowledge about the molecular mechanisms linking stress and obesity is a crucial requirement of translational research and using rodent models can significantly advance the important search for risk-related biomarkers and the development of clinical intervention strategies.

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Biophysical modeling: Multicompartment biophysical models for brain tissue microstructure imaging

Farooq,

Pisharady,

Lenglet

2024

Computational and Network Modeling of Neuroimaging Data

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The future of neuroimaging and gut-brain axis research for substance use disorders

Cited by 8 publications

References 163 publications

Opioid Analgesics after Bariatric Surgery: A Scoping Review to Evaluate Physiological Risk Factors for Opioid-Related Harm

Opioid Analgesics after Bariatric Surgery: A Scoping Review to Evaluate Physiological Risk Factors for Opioid-Related Harm

Neurobiological Mechanisms Modulating Emotionality, Cognition and Reward-Related Behaviour in High-Fat Diet-Fed Rodents

Biophysical modeling: Multicompartment biophysical models for brain tissue microstructure imaging

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