The future of lymphoma diagnosis, prognosis, and treatment monitoring in countries with limited access to pathology services

Chamba, Clara; Mawalla, William

doi:10.1053/j.seminhematol.2023.07.004

Seminars in Hematology

2023

DOI: 10.1053/j.seminhematol.2023.07.004

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The future of lymphoma diagnosis, prognosis, and treatment monitoring in countries with limited access to pathology services

Clara Chamba,

William Mawalla

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Cited by 2 publications

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Special edition of the Seminars in Hematology series on Global Hematology Care

Schuh

2023

Seminars in Hematology

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Special edition of the Seminars in Hematology series on Global Hematology Care

Schuh

2023

Seminars in Hematology

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An AI based, open access screening tool for early diagnosis of Burkitt lymphoma

Nambiar,

Rajesh,

Nair

et al. 2024

Front. Med.

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Burkitt Lymphoma (BL) is a highly treatable cancer. However, delayed diagnosis of BL contributes to high mortality in BL endemic regions of Africa. Lack of enough pathologists in the region is a major reason for delayed diagnosis. The work described in this paper is a proof-of-concept study to develop a targeted, open access AI tool for screening of histopathology slides in suspected BL cases. Slides were obtained from a total of 90 BL patients. 70 Tonsillectomy samples were used as controls. We fine-tuned 6 pre-trained models and evaluated the performance of all 6 models across different configurations. An ensemble-based consensus approach ensured a balanced and robust classification. The tool applies novel features to BL diagnosis including use of multiple image magnifications, thus enabling use of different magnifications of images based on the microscope/scanner available in remote clinics, composite scoring of multiple models and utilizing MIL with weak labeling and image augmentation, enabling use of relatively low sample size to achieve good performance on the inference set. The open access model allows free access to the AI tool from anywhere with an internet connection. The ultimate aim of this work is making pathology services accessible, efficient and timely in remote clinics in regions where BL is endemic. New generation of low-cost slide scanners/microscopes is expected to make slide images available immediately for the AI tool for screening and thus accelerate diagnosis by pathologists available locally or online.

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The future of lymphoma diagnosis, prognosis, and treatment monitoring in countries with limited access to pathology services

Cited by 2 publications

References 48 publications

Special edition of the Seminars in Hematology series on Global Hematology Care

Special edition of the Seminars in Hematology series on Global Hematology Care

An AI based, open access screening tool for early diagnosis of Burkitt lymphoma

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