The future of human uterine transplantation: can minimally invasive techniques provide a uterus suitable for transplant?

Falcone, Tommaso; Farrell, Ruth M.; Flyckt, Rebecca

doi:10.1016/j.fertnstert.2017.06.021

Cited by 9 publications

(7 citation statements)

References 5 publications

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“…As the technique of uterus transplantation is quickly evolving, several key issues remain to be determined. Foremost is whether a uterus obtained through minimally invasive techniques can result in a live birth and mitigate some of the risks associated with open living-donor surgery (25). Robotic and laparoscopic approaches have been described recently (26,27).…”

Section: Inclusion Exclusionmentioning

confidence: 99%

American Society for Reproductive Medicine position statement on uterus transplantation: a committee opinion

Allyse¹,

Amer²,

Coutifaris³

et al. 2018

Fertility and Sterility

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Following the birth of the first child from a transplanted uterus in Gothenburg, Sweden, in 2014, other centers worldwide have produced scientific reports of successful uterus transplantation, as well as more recent media reports of successful births. The American Society for Reproductive Medicine recognizes uterus transplantation as the first successful medical treatment of absolute uterus factor infertility, while cautioning health professionals, patient advocacy groups, and the public about its highly experimental nature.

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Section: Inclusion Exclusionmentioning

confidence: 99%

American Society for Reproductive Medicine position statement on uterus transplantation: a committee opinion

Allyse¹,

Amer²,

Coutifaris³

et al. 2018

Fertility and Sterility

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“…27-28, 44, 49 There has been controversy surrounding the safety of using minimally invasive surgical techniques for an already high risk procedure, especially with the removal of ovaries in premenopausal women in order to use the utero-ovarian veins for vascular anastomosis. 66 Use of this technique has also resulted in additional complications from increased length of procedure and time in the Trendelenburg position. 44…”

Section: Surgical Techniquementioning

confidence: 99%

Uterine Transplantation: Evolving Data, Success, and Clinical Importance

Ricci

Bennett

Falcone

2021

Journal of Minimally Invasive Gynecology

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“…5,6 From a technical standpoint, it is imperative to establish a steady inflow and outflow of the graft. 7 The specifics of the technique and the optimal number of venous anastomoses have yet to be clarified. Furthermore, the type of donor (LD vs DD) may pose substantial limitations to the length and diameter of the procured vessels.…”

Section: Introductionmentioning

confidence: 99%

“…Live births have been achieved with uterine grafts procured from living donors (LD) 4 as well as from deceased donors (DD) 5,6 . From a technical standpoint, it is imperative to establish a steady inflow and outflow of the graft 7 . The specifics of the technique and the optimal number of venous anastomoses have yet to be clarified.…”

Section: Introductionmentioning

confidence: 99%

Human uterine vasculature with respect to uterus transplantation: A comprehensive review

Křístek

Johannesson

Novotný

et al. 2020

J of Obstet and Gynaecol

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Due to the novelty of uterus transplantation, data on preferable inflow and outflow of the graft are limited. This paper reviews the technique, type of vessels and the outcome. A systematic search of the PubMed database was conducted. We extracted and analyzed data on the arteries and veins utilized, types of anastomosis, types of donors, complications and the outcome. Thirty eight sources reported 51 human uterine transplantations, 10 graft thromboses and 25 live births. Inflow was established with two uterine arteries (UA) with/without the anterior division of the internal iliac artery in 62% (n = 31) of cases, two UA arteries with a segment/patch of the internal iliac artery in 34% (n = 17) of cases or two UA with a conduit in 4% of cases (n = 2). Both cases with a conduit developed thrombosis (n = 2). Arterial thrombosis/ischemia developed in 8 of the 51 cases. In 50% of cases with arterial thrombosis, atherosclerosis was identified as a possible cause. Outflow was established by two internal iliac veins with patches/segments in 27.5% of cases (n = 14) followed by two utero-ovarian veins in 25.5% (n = 13). Venous thrombosis occurred in 3 of the 51 cases. Uterine arteries with/without anterior division of the internal iliac artery were the most frequent arteries used for inflow and produced the highest patency rate. The presence of atherosclerosis and complex arterial reconstruction was associated with a high rate of arterial thrombosis. None of the veins utilized in the procedures appeared to be superior. There are insufficient data to draw a definite conclusion.

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The future of human uterine transplantation: can minimally invasive techniques provide a uterus suitable for transplant?

Cited by 9 publications

References 5 publications

American Society for Reproductive Medicine position statement on uterus transplantation: a committee opinion

American Society for Reproductive Medicine position statement on uterus transplantation: a committee opinion

Uterine Transplantation: Evolving Data, Success, and Clinical Importance

Human uterine vasculature with respect to uterus transplantation: A comprehensive review

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