The global building sector has great potential for energy savings. Retrofitting of existing buildings can effectively improve their energy and environmental sustainability. However, retrofitting is a complex task and requires proper Measurement & Verification (M&V) to validate the process for various building types and locations. Such M&V studies for commercial buildings in the studied region are missing and a critical gap exists. This paper addresses this gap by discussing the effectiveness of retrofit energy and water efficiency measures implemented in a commercial building in Saudi Arabia. At first, a thorough energy audit is conducted and then five Energy Efficiency Measures (EEMs) and a water conservation measure is implemented. A post-retrofit M&V exercise is conducted to measure and validate the savings along with respective economic benefits. The results indicate that the implemented EEMs reduced the building’s annual energy consumption by 27%. The overall compound payback period for the investments is found to be six years. The study successfully validates the energy and water savings achievable through retrofitting by presenting the first M&V case study of a post-retrofit commercial building in the country. Thus, it proves that implementation of EEMs and water saving measures are effective strategies to retrofit commercial buildings in the region.