The Future of Cardiovascular Imaging

Carli, Marcelo F. Di; Geva, Tal; Davidoff, Ravin

doi:10.1161/circulationaha.116.023511

Cited by 41 publications

(40 citation statements)

References 181 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These abnormalities are often manifested by disturbed fluid dynamics 10 (local hemodynamics), and in many cases by an increase in the heart workload (global hemodynamics). Hemodynamicsquantification can be greatly useful for accurate and early diagnosis butwe still lack proper diagnostic methods for many cardiovascular diseases [11][12][13] because the hemodynamics analysis methods that can be used as engines of new diagnostic tools are not well developed yet. Furthermore, as most interventions intend to recover the healthy condition, the ability to monitor and predict hemodynamics following particular interventions can have significant impacts on saving lives.…”

mentioning

confidence: 99%

See 1 more Smart Citation

A diagnostic, monitoring, and predictive tool for patients with complex valvular, vascular and ventricular diseases

Keshavarz‐Motamed

2020

Sci Rep

100

View full text Add to dashboard Cite

Hemodynamics quantification is critically useful for accurate and early diagnosis, but we still lack proper diagnostic methods for many cardiovascular diseases. furthermore, as most interventions intend to recover the healthy condition, the ability to monitor and predict hemodynamics following interventions can have significant impacts on saving lives. Predictive methods are rare, enabling prediction of effects of interventions, allowing timely and personalized interventions and helping critical clinical decision making about life-threatening risks based on quantitative data. In this study, an innovative non-invasive imaged-based patient-specific diagnostic, monitoring and predictive tool (called C3VI-CMF) was developed, enabling quantifying (1) details of physiological flow and pressures through the heart and circulatory system; (2) heart function metrics. C3VI-CMF also predicts the breakdown of the effects of each disease constituents on the heart function. Presently, neither of these can be obtained noninvasively in patients and when invasive procedures are undertaken, the collected metrics cannot be by any means as complete as the ones C3VI-CMF provides. C3VI-CMF purposefully uses a limited number of noninvasive input parameters all of which can be measured using Doppler echocardiography and sphygmomanometer. Validation of C3VI-CMF, against cardiac catheterization in forty-nine patients with complex cardiovascular diseases, showed very good agreement with the measurements.prediction of effects of interventions, allowing timely and personalized interventions, and helping critical clinical decision making about life-threatening risks based on quantitative data.The heart resides in a sophisticated vascular network whose loads impose boundary conditions on the heart function 6,7,14-16 . Effective diagnosis and prediction hinge on quantifications of the global hemodynamics (heart workload) and of the local hemodynamics (detailed information of the dynamics of the circulatory system, e.g., flow and pressure) of the cardiovascular system as all are very important for long-term health of the heart 6,14,16 . However, there is no method to invasively or noninvasively quantify the heart workload (global hemodynamics) and to provide contribution breakdown of each component of the cardiovascular diseases. Moreover, current diagnostic methods are limited and cannot quantify detailed information of the flow dynamics of the circulatory system (local hemodynamics). Although all of these can provide valuable information about the patient's state of cardiac deterioration and heart recovery, currently, clinical decisions are chiefly made based on the anatomy alone. To augment anatomical information, cardiac catheterization is used as the clinical gold standard to evaluate pressure and flow through heart and circulatory system but it is invasive, expensive, high risk and therefore not practical for diagnosis in routine daily clinical practice or serial follow-up examinations 17 . Most importantly, cardiac catheterization only pro...

show abstract

mentioning

confidence: 99%

“…Furthermore, as most interventions intend to recover the healthy condition, the ability to monitor and predict hemodynamics following particular interventions can have significant impacts on saving lives. Despite remarkable advances in medical imaging, imaging on its own is not predictive 11,14 . Predictive methods are rare.…”

mentioning

confidence: 99%

A diagnostic, monitoring, and predictive tool for patients with complex valvular, vascular and ventricular diseases

Keshavarz‐Motamed

2020

Sci Rep

100

View full text Add to dashboard Cite

show abstract

“…The progressive technological evolution has led the world of cardiac imaging to technical improvements considered unexpected only a few years ago. In a few years, there has been a move from two-dimensional diagnostic imaging, very operator-dependent, to the current highly sophisticated and integrative multimodality imaging approach [48] . This is certainly a great innovation and the next frontier for those who…”

Section: Multimodality and Fusion Imaging Technologiesmentioning

confidence: 99%

The frontier in Cardiac Surgery is intellectual

Mestres¹,

Pozzoli²,

Taramasso³

et al. 2019

View full text Add to dashboard Cite

Cardiac Surgery is a Specialty undergoing profound changes. Since its inception, innovation has been at the forefront of activities seeking for the best of the patients. The introduction of the heart-lung machine in clinical practice in the 1950s of the twentieth century allowed for the correction of intra-and extracardiac defects. The recent past two decades have seen the progressive incorporation of transcatheter therapies to treat a variety of heart defects. Multimodality imaging approach has become a fundamental tool in the pre-intra-and postoperative assessment of patients. The future in Cardiac Surgery contemplates redesigning training programs with the mandatory acquisition of catheter skills, the knowledge of the different imaging modalities and allocation of resources and timing for basic and translational research.

show abstract

“…Over the last decade, we have witnessed an explosive expansion in the armamentarium of imaging technologies capable of providing detailed information about the structure and function of the heart and vasculature resulting in unprecedented improvements to our ability to diagnose disease, improve patient care, and advance biomedical research. 1 Cardiovascular imaging approaches are powerful as they are non-invasive, targeted to the specific biology, and highly quantitative. Along with clinical, molecular, and genome-wide association studies, structural and functional quantitative imaging already plays a critical role in phenotyping cardiovascular disease.…”

mentioning

confidence: 99%