Aloe vera (AV) is a multi-benefit plant well known for diverse applications due to its unique gel. This gel contains high-quality oil used to produce a high range of phytochemical products where the quantity and quality depend to stress factors including climatic variables. This study presents a review of AV components and the impact of stress factors including climate change (CC) through a bibliometric analysis. For the trend, research on this plant, its products, and CC tends towards the chemistry aspect and the use of scanning electron microscopy, phytotherapy, metabolism, and CC. Thus, CC was highlighted as a trending topic but not well explored. The topic of CC was well mentioned but the majority of research efforts explored it partially or generally. The results showed that temperature and precipitation are the most important climatic variables that affect the aloe species. However, water and saline stress increases the quality of the gel and reduces the growth and leaf yield.