The Future Is Coming: Artificial Intelligence in the Treatment of Infertility Could Improve Assisted Reproduction Outcomes—The Value of Regulatory Frameworks

Medenica, Sanja; Zivanovic, Dusan; Batkoska, Ljubica; Marinelli, S; Basile, Giuseppe; Perino, Antonio; Cucinella, Gaspare; Gullo, Giuseppe; Zaami, Simona

doi:10.3390/diagnostics12122979

Cited by 41 publications

(30 citation statements)

References 88 publications

(94 reference statements)

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“…At present, artificial intelligence (AI) has gradually been applied in many fields of medicine. By combining knowledge with computer science through machine learning algorithms, AI has the potential to improve infertility diagnosis and ART estimation results [ 57 ]. Bachelot et al [ 58 ] conducted a study in which they proposed a highly promising machine learning model that can stratify infertile/fertile couples based on their biological clinical characteristics, thereby helping to manage unexplained infertile couples.…”

Section: Discussionmentioning

confidence: 99%

University students’ fertility awareness and its influencing factors: a systematic review

Ren,

Xie,

et al. 2023

Reprod Health

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Introduction In recent years, a growing number of researchers have begun to study fertility awareness (FA). Evidence suggests that college students in their reproductive years have a common understanding of fertility, risk factors for infertility, and assisted reproductive technologies. Therefore, this systematic review summarizes these studies and explores the factors affecting college students’ fertility awareness. Methods A systematic literature search of databases (PUBMED/MEDLINE, Cochrane, Web of Science, Embase, and EBSCO) was conducted from inception to September 2022. Studies that assessed the levels of fertility awareness and factors influencing college students were considered for the review. The qualities of the included studies were evaluated using the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. This systematic review is reported according to the preferred reporting items for systematic review (PRISMA) guidelines. Results Twenty-one articles met the eligibility criteria and were included. The preliminary results showed that participants reported low to moderate FA. Female medical students demonstrated higher levels of fertility awareness. The association between age, years of education, and FA was insufficient. Conclusion The results of the current study suggest that increased FA interventions are warranted, especially for the male, non-medical student population. Governments and educational institutions should strengthen education programs for young students on reproductive health to help them raise awareness about childbirth, and society should provide family support for young people.

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Section: Discussionmentioning

confidence: 99%

University students’ fertility awareness and its influencing factors: a systematic review

Ren,

Xie,

et al. 2023

Reprod Health

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“…ART advancements such as using artificial intelligence to boost fertility outcomes have also sparked hope among aspiring parents. 49 Furthermore, many men recognized that conceiving could be a problem and showed increased appreciation for getting pregnant. Other studies have also proven that men feel differently from couples who have conceived naturally.…”

Section: Discussionmentioning

confidence: 99%

Experiences of men undergoing assisted reproductive technology: A qualitative systematic review

Hya,

Huang,

Chua

et al. 2023

Intl J Gynecology & Obste

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BackgroundMany infertile couples undergo assisted reproductive technology (ART) to increase pregnancy chances, with many of them experiencing psychosocial distress. Although research has been performed on women's experiences of ART, there is limited focus on men.ObjectiveThis systematic review consolidated and synthesized men's experiences with ART to better understand their needs and challenges to support them.Search StrategyNine electronic databases were searched from the inception date until November 2022.Selection CriteriaThis review included published and unpublished primary studies with qualitative methodologies exploring men's experiences with ART.Data Collection and AnalysisThe screening of studies, methodological assessment, data extraction, and analysis were conducted by two reviewers independently. The data were thematically synthesized.Main ResultsFifteen studies were included. An overarching theme of “despair to destiny” was identified, with four synthesized themes: (1) “the roller coaster ride,” (2) “what made it from bad to worse?”, (3) “what kept men going?”, and (4) “hopeful for the future.”ConclusionMen undergoing ART experienced struggles, a transition of emotions, and a need for support as they attempted to cope with unknowns while remaining hopeful for future outcomes. There is a need for health care interventions and policies to address the issue to improve the well‐being of male ART patients. Interventions should be tailored to the specific support groups that cater to the emotional and informational needs of male ART patients. Future research should focus on the influence of cultural sensitivities on men's ART experiences, to tailor support programs to address their psychological needs during ART.

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“…The integration of knowledge and computer science through machine learning algorithms should be adopted in male infertility diagnostic approaches, as well as in searches for targeted therapies ( 158 ).…”

Section: Male Infertility Preventive Strategiesmentioning

confidence: 99%

Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight

et al. 2023

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Male infertility is a widely debated issue that affects males globally. There are several mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with sperm quality and quantity affected by the overproduction of free radicals. Excess reactive oxygen species (ROS) cannot be controlled by the antioxidant system and, thus, potentially impact male fertility and hamper sperm quality parameters. Mitochondria are the driving force of sperm motility; irregularities in their function may lead to apoptosis, alterations to signaling pathway function, and, ultimately, compromised fertility. Moreover, it has been observed that the prevalence of inflammation may arrest sperm function and the production of cytokines triggered by the overproduction of ROS. Further, oxidative stress interacts with seminal plasma proteomes that influence male fertility. Enhanced ROS production disturbs the cellular constituents, particularly DNA, and sperms are unable to impregnate the ovum. Here, we review the latest information to better understand the relationship between oxidative stress and male infertility, the role of mitochondria, the cellular response, inflammation and fertility, and the interaction of seminal plasma proteomes with oxidative stress, as well as highlight the influence of oxidative stress on hormones; collectively, all of these factors are assumed to be important for the regulation of male infertility. This article may help improve our understanding of male infertility and the strategies to prevent it.

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The Future Is Coming: Artificial Intelligence in the Treatment of Infertility Could Improve Assisted Reproduction Outcomes—The Value of Regulatory Frameworks

Cited by 41 publications

References 88 publications

University students’ fertility awareness and its influencing factors: a systematic review

University students’ fertility awareness and its influencing factors: a systematic review

Experiences of men undergoing assisted reproductive technology: A qualitative systematic review

Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight

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