2019
DOI: 10.1371/journal.ppat.1007620
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The fungal ribonuclease-like effector protein CSEP0064/BEC1054 represses plant immunity and interferes with degradation of host ribosomal RNA

Abstract: The biotrophic fungal pathogen Blumeria graminis causes the powdery mildew disease of cereals and grasses. We present the first crystal structure of a B . graminis effector of pathogenicity (CSEP0064/BEC1054), demonstrating it has a ribonuclease (RNase)-like fold. This effector is part of a group of RNase-like proteins (termed RALPHs) which comprise the largest set of secreted effector candidates within the B . … Show more

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Cited by 116 publications
(132 citation statements)
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References 95 publications
(130 reference statements)
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“…An extension of this concept is the evolution of catalytically inactive variants of secreted proteins. Examples include the functional conversion of a glutathione synthetase in a plant-parasitic nematode (Lilley et al, 2018), enzymatically inactive fungal chitinases that sequester immunogenic chitin fragments (Fiorin et al, 2018), or the large family of catalytically inactive RNase-like effector proteins in cereal powdery mildews (Pennington et al, 2019).…”
Section: Creating Diversity By Generating Novel Effectors or Effementioning
confidence: 99%
“…An extension of this concept is the evolution of catalytically inactive variants of secreted proteins. Examples include the functional conversion of a glutathione synthetase in a plant-parasitic nematode (Lilley et al, 2018), enzymatically inactive fungal chitinases that sequester immunogenic chitin fragments (Fiorin et al, 2018), or the large family of catalytically inactive RNase-like effector proteins in cereal powdery mildews (Pennington et al, 2019).…”
Section: Creating Diversity By Generating Novel Effectors or Effementioning
confidence: 99%
“…Some of these putative effectors are expressed primarily in haustoria (Spanu, 2017). Recently, the first structure of an effector from Blumeria , that of BEC1054, was determined and showed structural similarities with ribonucleases; they were hence named RNase‐like proteins expressed in haustoria (RALPHs; Pennington et al , 2019; Fig. 2c).…”
Section: Domains Motifs and Scaffolds – What Does The Fold Unfold?mentioning
confidence: 99%
“…Like MAX effectors, RALPHs are predicted to contain a disulfide bond, as do the ribonucleases they share structural homology with. BEC1054 is proposed to mediate virulence by functioning as a pseudoenzyme to impede host ribosome inactivating proteins (RIPs) and inhibit host cell death (Pennington et al , 2019).…”
Section: Domains Motifs and Scaffolds – What Does The Fold Unfold?mentioning
confidence: 99%
“…Notably, a role for mechanosensing has been proposed for the receptor kinase Feronia (Hamant & Haswell, 2017), which was shown to be required for proper re-localization of MLO7/NORTIA to the site of pollen tube contact in the synergid cell (Kessler et al, 2010;. However, other cues may activate MLO, for example, both Blumeria graminis and R. irregularis produce effectors that could target MLO (Kloppholz et al, 2011;Requena et al, 2018;Pennington et al, 2019;Saur et al, 2019).…”
Section: Discussionmentioning
confidence: 99%