The fungal Myrothecium genus as a source of bioactive secondary metabolites

Sun, Tao; Zhu, Hua‐Jie; Cao, Fei

doi:10.1016/b978-0-12-817905-5.00006-8

Cited by 3 publications

(2 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both the asexual and the sexual stages of Myrothecium are very similar to those known for representatives of the genus Stachybotrys (Melanopsamma) [47,49]. Furthermore, species of the genus Myrothecium, in particular M. roridum and M. verrucaria, like Stachybotrys chartarum, produce secondary metabolites that are highly toxic to cells of other eukaryotes [50][51][52].…”

Section: Taxonomic Positionmentioning

confidence: 56%

Update on Stachybotrys chartarum—Black Mold Perceived as Toxigenic and Potentially Pathogenic to Humans

Dyląg

Spychała

Zielinski

et al. 2022

Biology

View full text Add to dashboard Cite

In nature, there are many species of fungi known to produce various mycotoxins, allergens and volatile organic compounds (VOCs), as well as the commonly known etiological agents of various types of mycoses. So far, none of them have provoked so much emotion among homeowners, builders, conservators, mycologists and clinicians as Stachybotrys chartarum. This species compared to fungi of the genera Fusarium and Aspergillus is not as frequently described to be a micromycete that is toxigenic and hazardous to human and animal health, but interest in it has been growing consistently for three decades. Depending on the authors of any given review article, attention is focused either on the clinical aspects alongside the role of this fungus in deterioration of biomaterials, or aspects related to its biology, ecology and taxonomic position. On the one hand, it is well established that inhalation of conidia, containing the highest concentrations of toxic metabolites, may cause serious damage to the mammalian lung, particularly with repeated exposure. On the other hand, we can find articles in which authors demonstrate that S. chartarum conidia can germinate and form hyphae in lungs but are not able to establish an effective infection. Finally, we can find case reports that suggest that S. chartarum infection is linked with acute pulmonary hemorrhage, based on fungal structures recovered from patient lung tissue. New scientific reports have verified the current state of knowledge and note that clinical significance of this fungus is exceedingly controversial. For these reasons, understanding S. chartarum requires reviewing the well-known toxigenic features and harmful factors associated with this fungus, by gathering the newest ones into a coherent whole. The research problem related to this fungus seems to be not overly publicized, and there is still a demand to truthfully define the real threats of S. chartarum and phylogenetically related species. The most important problem, which should be fully elucidated as soon as possible, remains the clarification of the pathogenicity of S. chartarum and related species. Maybe it is urgent time to ask a critical question, namely what exactly do we know 28 years after the outbreak of pulmonary hemorrhage in infants in Cleveland, Ohio, USA most likely caused by S. chartarum?

show abstract

Section: Taxonomic Positionmentioning

confidence: 56%

Update on Stachybotrys chartarum—Black Mold Perceived as Toxigenic and Potentially Pathogenic to Humans

Dyląg

Spychała

Zielinski

et al. 2022

Biology

View full text Add to dashboard Cite

show abstract

“…In addition, the genus has also been reported in human blood ( Masetti et al 2020 ) and soil ( Gurung et al 2019 , Murgia et al 2019 ). Several genera of Stachybotryaceae , such as Albifimbria , Memnoniella , Myrothecium and Stachybotrys , are capable of producing bioactive compounds ( Pervez et al 2015 , Wang et al 2015 , Li et al 2020 , Sun et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Taxonomy and phylogeny of Smaragdiniseta musae sp. nov. and Albifimbria verrucaria (Hypocreales, Stachybotryaceae) on Musa from Thailand

Samarakoon¹,

Wanasinghe²,

Bhat³

et al. 2022

BDJ

176

View full text Add to dashboard Cite

Smaragdiniseta musae is introduced as a leaf-based novel saprobic species from Musa. Multi-gene phylogenetic analyses of internal transcribed spacer (ITS), RNA polymerase II second largest subunit (rpb2) and β-tubulin (tub2) data support the taxonomic placement of the new collection in Smaragdiniseta (Hypocreales, Stachybotryaceae). The novel species is characterised by cup-shaped sporodochia covered by numerous peripheral setae and simple hyaline, guttulate conidia produced by the ultimate branches (phialides) of conidiophores. This is the first report of Smaragdiniseta from Thailand and on Musaceae. In addition, we report Albifimbria verrucaria for the first time from Thailand, based on morpho-molecular evidence.

show abstract

Trigochromene A, a new chromane dimer and other components from Trigonostemon howii and their antiproliferative activity

Yang

Jiang

Yang

et al. 2023

Phytochemistry Letters

View full text Add to dashboard Cite

The fungal Myrothecium genus as a source of bioactive secondary metabolites

Cited by 3 publications

References 108 publications

Update on Stachybotrys chartarum—Black Mold Perceived as Toxigenic and Potentially Pathogenic to Humans

Update on Stachybotrys chartarum—Black Mold Perceived as Toxigenic and Potentially Pathogenic to Humans

Taxonomy and phylogeny of Smaragdiniseta musae sp. nov. and Albifimbria verrucaria (Hypocreales, Stachybotryaceae) on Musa from Thailand

Trigochromene A, a new chromane dimer and other components from Trigonostemon howii and their antiproliferative activity

Contact Info

Product

Resources

About