The Fungal Intestinal Microbiota Predict the Development of Bronchopulmonary Dysplasia in Very Low Birthweight Newborns

Willis, Kent A.; Silverberg, Mary; Abdelgawad, Ahmed; Martin, Isaac; Tanaka, Kosuke; Halloran, Brian; Myers, Erin D.; Lal, Charitharth Vivek; Ambalavanan, Namasivayam; Jilling, Tamás; Tipton, Laura; Pierre, Joseph F.; Talati, Ajay J.

doi:10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4223

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Willis and co-workers sought to identify the fungal component of the microbiome, or mycobiome, in stool samples from preterm infants. They demonstrated an increased diversity of the mycobiome in samples from infants who developed CLD, and these infants had a lower relative abundance of Candida and a higher relative abundance of rarer fungal taxa including Mortierella when compared to those who did not develop CLD [ 29 ].…”

Section: Gut Microbiota and Cldmentioning

confidence: 99%

The Role of the Airway and Gut Microbiome in the Development of Chronic Lung Disease of Prematurity

Boel,

Gallacher,

Marchesi

et al. 2024

Pathogens

View full text Add to dashboard Cite

Chronic lung disease (CLD) of prematurity, a common cause of morbidity and mortality in preterm-born infants, has a multifactorial aetiology. This review summarizes the current evidence for the effect of the gut and airway microbiota on the development of CLD, highlighting the differences in the early colonisation patterns in preterm-born infants compared to term-born infants. Stool samples from preterm-born infants who develop CLD have less diversity than those who do not develop CLD. Pulmonary inflammation, which is a hallmark in the development of CLD, may potentially be influenced by gut bacteria. The respiratory microbiota is less abundant than the stool microbiota in preterm-born infants. There is a lack of clear evidence for the role of the respiratory microbiota in the development of CLD, with results from individual studies not replicated. A common finding is the presence of a single predominant bacterial genus in the lungs of preterm-born infants who develop CLD. Probiotic preparations have been proposed as a potential therapeutic strategy to modify the gut or lung microbiota with the aim of reducing rates of CLD but additional robust evidence is required before this treatment is introduced into routine clinical practice.

show abstract

Section: Gut Microbiota and Cldmentioning

confidence: 99%

The Role of the Airway and Gut Microbiome in the Development of Chronic Lung Disease of Prematurity

Boel,

Gallacher,

Marchesi

et al. 2024

Pathogens

View full text Add to dashboard Cite

show abstract

The fungal intestinal microbiota predict the development of bronchopulmonary dysplasia in very low birthweight newborns

Willis

Silverberg

Martin

et al. 2023

Preprint

View full text Add to dashboard Cite

Rationale: Bronchopulmonary dysplasia (BPD) is the most common morbidity affecting very preterm infants. Gut microbial communities contribute to multiple lung diseases, and alterations of the gut microbiome may be a factor in BPD pathogenesis. Objective: To determine if features of the multikingdom gut microbiome predict the development of BPD in very low birthweight newborns. Methods: We performed a prospective, observational cohort study comparing the multikingdom fecal microbiota of 147 very low birthweight infants with BPD or post-prematurity respiratory disease (PPRD) by sequencing bacterial 16S and fungal ITS2 ribosomal RNA. To address the potential causative relationship between gut dysbiosis and BPD, we used fecal microbiota transplant in an antibiotic-pseudohumanized mouse model. Comparisons were made using RNA sequencing, quantitative confocal microscopy, lung morphometry, and oscillometry. Measurements and Main Results: We analyzed 100 fecal microbiome samples collected during the second week of life. Infants who later developed BPD showed an obvious fungal dysbiosis as compared to infants with PPRD (P = 0.0209). Instead of fungal communities dominated by Candida and Saccharomyces, the microbiota of infants who developed BPD were characterized by the abundance of Aureobasidium and a greater diversity of rarer fungi in less interconnected community architectures. On successful colonization, the gut microbiota from infants with BPD augmented lung injury in the offspring of recipient animals. We identified alterations in the murine lung and intestinal microbiomes and transcriptional alterations associated with augmented lung injury. Conclusions: The gut fungal microbiome of infants who will develop BPD is dysbiotic and may contribute to disease pathogenesis.

show abstract

The Fungal Intestinal Microbiota Predict the Development of Bronchopulmonary Dysplasia in Very Low Birthweight Newborns

Cited by 2 publications

References 0 publications

The Role of the Airway and Gut Microbiome in the Development of Chronic Lung Disease of Prematurity

The Role of the Airway and Gut Microbiome in the Development of Chronic Lung Disease of Prematurity

The fungal intestinal microbiota predict the development of bronchopulmonary dysplasia in very low birthweight newborns

Contact Info

Product

Resources

About