“…41 Very recently, Haritha and Suresh have conducted quantification of hydrogen bond strength between water and various chemical motifs (OC–NH, FC–CH, OC–CH, N–CO, N–C–NH, N–CH) frequently encountered in rings in drugs, and the findings indicate that variation in the MESP at the nuclei, Δ V n , of interacting atoms within each motif plays a pivotal role in predicting the strength of these hydrogen bond interactions. 38,42 In the ring molecule, the ordered pairs of (Δ V n of heteroatom, Δ V n of H atom) exhibited variations of (+, +), (+, −), (−, +), and (−, −) compared to a reference molecule. The (−, +) MESP behaviour consistently enhanced the (ring)heteroatom⋯H w and O w ⋯H(ring) interactions, while the (+, −) behaviour weakened these interactions.…”