The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer

Background: The study aims to assay the value of diffusion-weighted MR imaging over conventional dynamic liver MRI in the characterization and distinguishing of localized benign and malignant alterations in liver mass. Methods: All liver MRI scans taken at Imam Khomeini Hospital Imaging Center from November 2018 to October 2021 were studied. Demographic information of patients was recorded. One hundred and forty patients with 221 liver lesions and focal liver tumors were evaluated using TSE T2WI, GE T1WI, 3-T MRI tests. Dynamic imaging was performed using T1 THRIVE. The results were compared with histopathology, laboratory and other previous radiological results (US &/or MSCT) performed on all patients. All collected data were analysis with SPSS VER 18 software.

Section: Discussionmentioning

confidence: 95%

The added value of diffusion weighted MRI over standard dynamic liver MRI in characterization of focal liver lesions

2023

“…Several negative ocular effects have been reported following immunization with the AstraZeneca adenovirus vector vaccine. Acute macular neuroretinopathy, bilateral immunemediated keratolysis, and VKH disease have all been noted as possible side effects of vaccination (15)(16)(17)(18). A young, Caucasian, and healthy woman developed bilateral acute macular neuroretinopathy after receiving the first dose of Oxford-AstraZeneca COVID-19 vaccine in the study of (19).…”

Section: Discussionmentioning

confidence: 99%

Examination of the ocular inflammatory effects after COVID-19 - vaccine

2023

Background: Recent researches indicated that the ophthalmologic negative impacts of COVID-19 disease and COVID-19 vaccination are highly overlapping. Objective: The present study aimed to investigate the inflammatory side effects after COVID-19 vaccination. Patients and methods: A total of (60) cases who received two doses of COVID-19 vaccine were included to report ocular side effects appeared within14 days of receiving the second dose. Results: Uveitis was recorded in (60%) of the study population after COVID-19 vaccinations, while the other inflammatory side effects were distributed as follows; scleritis (15%), VKH (10%), other effects (8.4%) and neuroretinopathy(6.6%). The majority (71.67%) of the study population was treated by corticosteroids. Visual acuity lowered ≤ 3 lines in (25%) of other inflammatory conditions; VA lowered > 3 lines in (25%) of other inflammatory conditions and (5.56%) of uveitis. Conclusion: Following COVID-19 vaccination, ophthalmologic inflammatory events are possible.

“…the median lobe protrusion can cause obstructive effects because of the associated distortion of the funneling effect. Although benign prostatic enlargement (BPH) can consider as a cause to the occurrence of LUTS in men over 40 years of age, other factors may considered like neurological, anatomical, metabolic and inflammatory factors [27][28][29][30]. AUA guidelines recommend cystoscopy in those patients for whom the appearance of the prostate aids in the choice of surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

The Role of Cystoscopy for Patients with Lower Urinary Tract Symptoms (LUTS)

2023

Background and objective: LUTS affect the quality of patient's life from different aspects including social, physical and psychological with health cost impact. Cystoscopy is minimally invasive procedure that can be done in the office for the evaluation of the lower urinary tract. This study aimed to assess the role of cystoscopy for patients with lower urinary tract symptoms (LUTS) as a diagnostic tool when other investigational modalities are normal and its suitability for prompt intervention when possible. Methods:The study was conducted at a single urology center through the period from January 2019 to March 2020 that includes 60 eligible patient with bothersome long-term lower urinary tract symptoms (LUTS) with normal initial investigations. Cystoscopy was done to all included patients, percentages of detected relevant findings and interventional procedures are determined. Results: 60 patients were included in this study with a mean age of 38 years (32 male and 28 female) who underwent cystoscopy, positive findings was in 31 patients (51.6%), 20 male and 11 female. Clinically significant abnormalities were found in 14 patients (23.3 %) that includes: Urethral stricture (5%), intravesical calculi (6.6%), bladder tumor (5%), prostatic enlargement (3.3%), fistula (1.7%) and foreign body (1.7%). 14 patients (23.3 %) underwent concomitant cystoscopic interventional procedures doing in same time of examination. There was no significant difference between men and women with regard to the detected findings (P = 0.2). Conclusion: Cystoscopy is a valuable diagnostic modality that achieve rapid completion of diagnostic workup, and allow some surgical intervention to be done more promptly. It can be consider as integral tool in the management of patients with LUTS.