THE FUNCTIONING and SIGNIFICANCE OF THE LATERAL‐LINE ORGANS

Dijkgraaf, S.

doi:10.1111/j.1469-185x.1963.tb00654.x

Cited by 734 publications

(468 citation statements)

References 103 publications

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“…We found strong expression of zDL1b, zDL2, and zOTR in cells of the lateral line (Figure 5a), a mechanosensory system used by fish and amphibians to detect water displacement. 28 The lateral line is composed of individual sense organs called neuromasts that originate in the otic region and become spread along the body axis by long-range migration. 29 We detected zOTR in the otic placode at 16 h.p.f., and both zOTR and zDL1b in the migrating posterior lateral line (PLL) primordia at 30 h.p.f.…”

Section: Additional Sites Of Embryonic Expressionmentioning

confidence: 99%

Delineation of the cell-extrinsic apoptosis pathway in the zebrafish

et al. 2006

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The mammalian extrinsic apoptosis pathway is triggered by Fas ligand (FasL) and Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL). Ligand binding to cognate receptors activates initiator caspases directly in a death-inducing signaling complex. In Drosophila, TNF ligand binding activates initiator caspases indirectly, through JNK. We characterized the extrinsic pathway in zebrafish to determine how it operates in a nonmammalian vertebrate. We identified homologs of FasL and Apo2L/TRAIL, their receptors, and other components of the cell death machinery. Studies with three Apo2L/TRAIL homologs demonstrated that they bind the receptors zHDR (previously linked to hematopoiesis) and ovarian TNFR (zOTR). Ectopic expression of these ligands during embryogenesis induced apoptosis in erythroblasts and notochord cells. Inhibition of zHDR, zOTR, the adaptor zFADD, or caspase-8-like proteases blocked ligand-induced apoptosis, as did antiapoptotic Bcl-2 family members. Thus, the extrinsic apoptosis pathway in zebrafish closely resembles its mammalian counterpart and cooperates with the intrinsic pathway to trigger tissue-specific apoptosis during embryogenesis in response to ectopic Apo2L/TRAIL expression.

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Section: Additional Sites Of Embryonic Expressionmentioning

confidence: 99%

Delineation of the cell-extrinsic apoptosis pathway in the zebrafish

et al. 2006

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“…Lateral line hair cells cluster in sensory organs called neuromasts that are externally located on the head and body of the animal (Metcalf et al 1985;Coombs et al 1989;Raible and Kruse 2000). This sensory system is used to detect nearfield water movement and mediates a number of important behaviors including predator avoidance, prey capture, and orientation to flow (Dijkgraaf 1963;Montgomery and MacDonald 1987;Montgomery et al 1997;Coombs et al 2001;New et al 2001;Suli et al 2012). Lateral line hair cells and mammalian inner ear hair cells exhibit similar responses to ototoxic drugs, making the lateral line a suitable preparation for ototoxicity studies (Harris et al 2003;Ou et al 2007;Owens et al 2007;Hirose et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Bax, Bcl2, and p53 Differentially Regulate Neomycin- and Gentamicin-Induced Hair Cell Death in the Zebrafish Lateral Line

Coffin

Rubel

Raible

2013

JARO

101

116

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Sensorineural hearing loss is a normal consequence of aging and results from a variety of extrinsic challenges such as excessive noise exposure and certain therapeutic drugs, including the aminoglycoside antibiotics. The proximal cause of hearing loss is often death of inner ear hair cells. The signaling pathways necessary for hair cell death are not fully understood and may be specific for each type of insult. In the lateral line, the closely related aminoglycoside antibiotics neomycin and gentamicin appear to kill hair cells by activating a partially overlapping suite of cell death pathways. The lateral line is a system of hair cell-containing sense organs found on the head and body of aquatic vertebrates. In the present study, we use a combination of pharmacologic and genetic manipulations to assess the contributions of p53, Bax, and Bcl2 in the death of zebrafish lateral line hair cells. Bax inhibition significantly protects hair cells from neomycin but not from gentamicin toxicity. Conversely, transgenic overexpression of Bcl2 attenuates hair cell death due to gentamicin but not neomycin, suggesting a complex interplay of pro-death and pro-survival proteins in drug-treated hair cells. p53 inhibition protects hair cells from damage due to either aminoglycoside, with more robust protection seen against gentamicin. Further experiments evaluating p53 suggest that inhibition of mitochondrial-specific p53 activity confers significant hair cell protection from either aminoglycoside. These results suggest a role for mitochondrial p53 activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax and Bcl2.

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“…On page 428, Torrejon et al 1 report one of the first nanoscale neuromorphic computers to perform a classification task -in this case, speech recognition. The core of the computer is a magnetic device called a spintronic oscillator that operates at gigahertz frequencies.…”

Section: F R a N K H O P P E N St E A Dtmentioning

confidence: 99%

“…Crucially, the device's response depends on the timing of the input. The arrow continues to oscillate until the input is removed, at which 1 show that a nanoscale magnetic device called a spintronic oscillator can be used for speech recognition. Their oscillator comprises a non-magnetic material (yellow), sandwiched between two magnetic materials (blue and grey).…”

Section: F R a N K H O P P E N St E A Dtmentioning

confidence: 99%