The Functional State of Neutrophils in Patients With Immunoglobulin a Deficiency

Abstract

Objective: to evaluate the functional properties of neutrophils in patients with IgA deficiency. Material and methods. We have studied the functional state of neutrophils (phagocytosis, ability to form active forms of oxygen and extracellular traps) in 58 patients (33 women, 25 men) with the confirmed diagnosis of partial IgA deficiency (38 patients) and general variable immune deficiency (20 patients) with a decreased content of IgA and IgG. Results. Patients with IgA deficiency reveal increased oxygen-dependent ability of blood neutrophils to form extracellular traps. The maximum degree of increase in the indices of netosis is found in patients with a lower IgA value (less than 0.3 g/l). Conclusion. Patients with a defect in the production of IgA observe disturbances of the functional properties of blood neutrophils by way of activation of their ability to form extracellular networks. This fact can be one of the prerequisites of increased patients` predisposition to develop autoimmune pathology.