The functional role of octopaminergic neurons in insect motor behavior

Pflüger, Hans‐Joachim; Duch, Carsten

doi:10.1007/bf03543232

Cited by 14 publications

(7 citation statements)

References 52 publications

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“…It has been shown that the thoracic ganglia of insects have an important role in establishing a basic motor plan that can be centrally orchestrated by specific regions of the invertebrate brain, particularly the MB and CC [12] , [13] , [43] – [47] . Interestingly, BA systems play an important role in the execution of insect motor programs by acting on the motor neurons and the muscles they innervate [48] – [50] . They also contribute in the planning and execution of these motor programs through their actions in the insect brain, as it has been shown for the 5HT and DA systems ( [11] and [2] , respectively), possibly by modifying the activity of neurons in the CC and MB.…”

Section: Discussionmentioning

confidence: 99%

Serotonin Receptors Expressed in Drosophila Mushroom Bodies Differentially Modulate Larval Locomotion

et al. 2014

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Drosophila melanogaster has been successfully used as a simple model to study the cellular and molecular mechanisms underlying behaviors, including the generation of motor programs. Thus, it has been shown that, as in vertebrates, CNS biogenic amines (BA) including serotonin (5HT) participate in motor control in Drosophila. Several evidence show that BA systems innervate an important association area in the insect brain previously associated to the planning and/or execution of motor programs, the Mushroom Bodies (MB). The main objective of this work is to evaluate the contribution of 5HT and its receptors expressed in MB to motor behavior in fly larva. Locomotion was evaluated using an automated tracking system, in Drosophila larvae (3rd-instar) exposed to drugs that affect the serotonergic neuronal transmission: alpha-methyl-L-dopa, MDMA and fluoxetine. In addition, animals expressing mutations in the 5HT biosynthetic enzymes or in any of the previously identified receptors for this amine (5HT1AR, 5HT1BR, 5HT2R and 5HT7R) were evaluated in their locomotion. Finally, RNAi directed to the Drosophila 5HT receptor transcripts were expressed in MB and the effect of this manipulation on motor behavior was assessed. Data obtained in the mutants and in animals exposed to the serotonergic drugs, suggest that 5HT systems are important regulators of motor programs in fly larvae. Studies carried out in animals pan-neuronally expressing the RNAi for each of the serotonergic receptors, support this idea and further suggest that CNS 5HT pathways play a role in motor control. Moreover, animals expressing an RNAi for 5HT1BR, 5HT2R and 5HT7R in MB show increased motor behavior, while no effect is observed when the RNAi for 5HT1AR is expressed in this region. Thus, our data suggest that CNS 5HT systems are involved in motor control, and that 5HT receptors expressed in MB differentially modulate motor programs in fly larvae.

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Section: Discussionmentioning

confidence: 99%

Serotonin Receptors Expressed in Drosophila Mushroom Bodies Differentially Modulate Larval Locomotion

et al. 2014

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“…Specific subtypes of these neurons innervate muscles used in specific behaviors, such as walking or flying. It was thought that the DUM neurons functioned as a general arousal system, but recent work shows that during these tasks, DUM neurons are differently centrally activated according to behavioral context [170,171].…”

Section: The Role Of the Periphery In Producing Motormentioning

confidence: 99%

Invertebrate Central Pattern Generation Moves along

et al. 2005

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“…It is known that AKHs and octopamine also have very important roles in the regulation of insect locomotion (Socha et al 1999;Pflüger and Duch 2000). Thus, AKHs stimulate locomotion (Socha et al 1999) and mobilize various substrates (lipids, carbohydrates, proline) from stores in insect fat bodies during locomotion and flight (Gäde and Auerswald 2003;Lorenz et al 2004;Gáliková et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Important processes in the regulation of motor behavior are initiated by the neuroendocrine system (Orchard et al 1993;Osborne 1996;Nässel and Winther 2010). Octopamine is the most frequent insect amine that tunes both visceral and skeletal muscle activities (Roeder 1999) and has a functional role in motor behavior (Pflüger and Duch 2000). Other biogenic amines (dopamine, norepinephrine, serotonin, tyramine) also affect the production of AKHs (Van der Horst et al 2001) that have a neuromodulatory role and stimulate insect locomotion (Socha et al 1999).…”

Section: Introductionmentioning

confidence: 99%

The impact of chronic exposure to a magnetic field on energy metabolism and locomotion of Blaptica dubia

Todorović

Ilijin

Mrdaković

et al. 2020

International Journal of Radiation Biology

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Purpose: This study deals with a comparative analysis of the effects of chronic exposure to a static magnetic field (SMF) and an extremely low frequency magnetic field (ELF MF) in Blaptica dubia nymphs. The outcome of such treatment on insect and fat body mass, glycogen and total lipid content in the fat body and locomotion, as an energy demanding process, were examined.Materials and methods: One-month-old nymphs of B. dubia were exposed to an SMF (110 mT) or ELF MF (50 Hz, 10 mT) for 5 months. Their locomotion was monitored in the "open-field" test for 10 min and expressed as travel distance, time in movement and average speed while in motion. After that, fat body mass and content of its main components (glycogen and total lipids) were determined. Nymph body mass was also estimated after 1 and 5 months of MF treatment.Results: Chronic exposure to the SMF and ELF MF decreased nymph body mass and glycogen content in the fat body, but increased all examined parameters of locomotion. In addition, chronic SMF treatment elevated total lipid content in the fat body, while chronic ELF MF treatment reduced fat body mass and total lipid content.Conclusions: These findings indicate that B. dubia nymphs are sensitive to the applied MFs and possess different strategies for fuel usage in response to the SMF and ELF MF in order to satisfy increased energy demands and to overcome stressful conditions.

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The functional role of octopaminergic neurons in insect motor behavior

Cited by 14 publications

References 52 publications

Serotonin Receptors Expressed in Drosophila Mushroom Bodies Differentially Modulate Larval Locomotion

Serotonin Receptors Expressed in Drosophila Mushroom Bodies Differentially Modulate Larval Locomotion

Invertebrate Central Pattern Generation Moves along

The impact of chronic exposure to a magnetic field on energy metabolism and locomotion of Blaptica dubia

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