The functional relationship between hematopoietic stem cells and developing T lymphocytes

Wiekmeijer, Anna-Sophia; Brugman, Martijn H.; Pike-Overzet, Karin

doi:10.1111/nyas.12995

Cited by 6 publications

(4 citation statements)

References 91 publications

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“…The most robust criterion to determine true stem cell potential is the ability to provide long-term repopulation of an entire host with all hematopoietic lineages [ 8 ]. In mice, this is often assessed by performing transplantations in secondary recipients to determine self-renewal capacity [ 9 , 10 ]. For human HSCs, this is, of course, not feasible in a clinical setting.…”

Section: Hematopoietic Stem Cells As a Source For All Blood Cellsmentioning

confidence: 99%

The Development of T Cells From Stem Cells in Mice and Humans

2017

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T cells develop from hematopoietic stem cells in the specialized microenvironment of the thymus. The main transcriptional players of T-cell differentiation such as Notch, Tcf-1, Gata3 and Bcl11b have been identified, but their role and regulation are not yet completely understood. In humans, functional experiments on T-cell development have traditionally been rather difficult to perform, but novel in vitro culture systems and in vivo xenograft models have allowed detailed studies on human T-cell development. Recent work has allowed the use of human severe combined immunodeficiency stem cells to unravel developmental checkpoints for human thymocyte development.

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Section: Hematopoietic Stem Cells As a Source For All Blood Cellsmentioning

confidence: 99%

The Development of T Cells From Stem Cells in Mice and Humans

2017

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“…We chose the C57BL/6J genetic background based on our extensive experience with the model and its utility in concert with the extensively studied T, B, and NK cell-deficient B6.CB17-Prkdc scid /SzJ strain. [19][20][21][22][23][24][25] Additionally, the SCID model is amenable to xenografts, 26,27 allowing us to perform multiple variations of the adoptive Figure 5. Schematic illustration of the timeline of T cells involved in wound healing.…”

Section: Discussionmentioning

confidence: 99%

T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling

Wang

Balaji

Steen

et al. 2019

Advances in Wound Care

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While tissue injury and repair are known to involve adaptive immunity, the profile of lymphocytes involved and their contribution to dermal scarring remain unclear. We hypothesized that restoration of T cell deficiency attenuates dermal scarring. Approach: We assessed the temporal-spatial distribution of T lymphocytes and their subtypes during the physiological dermal wound repair process in mice. Also, we compared the scarring outcomes between wild-type (WT) and severe combined immunodeficient (SCID) mice, which are lymphocyte deficient. Complementary gain-of-function experiments were performed by adoptively transferring lymphocyte subsets to validate their contribution to tissue repair in wounded SCID mice. Results: CD4 + T lymphocytes were present within dermal wounds of WT mice beginning on day 1 and remained through day 30. Wounds of SCID mice exhibited accelerated closure, increased inflammation, limited neovascularization, and exacerbated scarring compared with WT mice. Conversely, transfer of either mixed B and T lymphocytes or CD4 + lymphocytes alone into SCID mice resulted in moderated healing with less inflammation, collagen deposition, and scarring than control SCID wounds. In contrast, transfer of other lymphocyte subsets, including helper T lymphocytes (CD3 + CD4 + CD25-), CD8 + T cells and B cells, or regulatory T lymphocytes (CD4 + CD25 + CD127 low), did not reduce scar. Innovation: The finding that lymphocytes delay wound healing but reduce scar is novel and provides new insights into how dermal scarring is regulated. Conclusion: Our data support a suppressive role for CD4 + T cells against inflammation and collagen deposition, with protective effects in early-stage dermal wound healing. These data implicate adaptive immunity in the regulation of scarring phenotypes.

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“…CD34 serves as a marker for human stem cells and progenitor cells, labeling T cell precursors in the thymus ( 26 ). Human DN thymocytes are divided into three subsets based on the expression of CD34, CD7, and CD1a, which correspond to the developmental order: CD34 + CD7 - CD1a - (Thy1), CD34 + CD7 + CD1a - (Thy2), and CD34 + CD7 + CD1a + (Thy3) ( 27 – 31 )( Figure 2 ). The expression of CD1a marks T cell lineage commitment, and Thy1 cells are the fewest and the earliest T cell precursors with multi-lineage differentiation potential including T cells, B cells, NK cells and myeloid cells in vitro ( 27 , 30 , 32 ).…”

Section: Ubiquitination Regulation Of T Cell Progenitorsmentioning

confidence: 99%

Mechanism study of ubiquitination in T cell development and autoimmune disease

Yu,

Yang,

Cao

et al. 2024

Front. Immunol.

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T cells play critical role in multiple immune processes including antigen response, tumor immunity, inflammation, self-tolerance maintenance and autoimmune diseases et. Fetal liver or bone marrow-derived thymus-seeding progenitors (TSPs) settle in thymus and undergo T cell-lineage commitment, proliferation, T cell receptor (TCR) rearrangement, and thymic selections driven by microenvironment composed of thymic epithelial cells (TEC), dendritic cells (DC), macrophage and B cells, thus generating T cells with diverse TCR repertoire immunocompetent but not self-reactive. Additionally, some self-reactive thymocytes give rise to Treg with the help of TEC and DC, serving for immune tolerance. The sequential proliferation, cell fate decision, and selection during T cell development and self-tolerance establishment are tightly regulated to ensure the proper immune response without autoimmune reaction. There are remarkable progresses in understanding of the regulatory mechanisms regarding ubiquitination in T cell development and the establishment of self-tolerance in the past few years, which holds great potential for further therapeutic interventions in immune-related diseases.

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The functional relationship between hematopoietic stem cells and developing T lymphocytes

Cited by 6 publications

References 91 publications

The Development of T Cells From Stem Cells in Mice and Humans

The Development of T Cells From Stem Cells in Mice and Humans

T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling

Mechanism study of ubiquitination in T cell development and autoimmune disease

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