The functional reconstruction of fertility-sparing radical abdominal trachelectomy for early stage cervical carcinoma

Yao, Tingting; Mo, Shaomin; Lin, Zhongqiu

doi:10.1016/j.ejogrb.2010.02.035

Cited by 26 publications

(6 citation statements)

References 11 publications

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“…We assessed the gynecological and obstetrical outcomes of 28 patients after ART at a single institution, and no recurrence occurred during a median of 43 months. Table summarizes the literature, which describes ≥10 cases of ART in which the pregnancy outcomes were confirmed, and the recurrence rate of CCA treated with ART was 2.8%. We believe that the reasons for the present favorable oncological results were the use of the criterion tumor size ≤2 cm, preoperative imaging, and the collection of frozen sections during surgery.…”

Section: Discussionmentioning

confidence: 99%

Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience

Tamauchi

Kajiyama

Sakata

et al. 2016

J of Obstet and Gynaecol

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Aim: Radical trachelectomy (RT) is a widely used fertility-sparing treatment for patients with early cervical cancer (CCA). RT, however, is an investigational treatment, and its gynecological and obstetric efficacy are being investigated. We retrospectively assessed the efficacy of abdominal RT (ART) as a fertility-sparing surgery. Methods: From 2010 to 2014, patients with stage IA2-IB1 CCA (tumor ≤2 cm) who wished to preserve their fertility underwent ART. The major outcomes were mortality, recurrence, pregnancy complications, and obstetric outcome. Results: Twenty-eight patients received ART. Adjuvant chemotherapy was performed in seven patients because of lymphovascular space invasion. During the median follow-up of 43 months, no recurrences occurred. Twelve women attempted to conceive, and eight of them became pregnant. A total of five children were born, and one baby was full term. Three cases of second trimester, and one case of third trimester preterm births were recorded. Conclusions: Fertility was preserved after ART in a moderate number of patients. The pregnancy and birth rates after ART have been improving, and increasing the full-term birth rate is the next goal. In addition, development of further types of minimally invasive surgery for CCA can be expected.

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Section: Discussionmentioning

confidence: 99%

Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience

Tamauchi

Kajiyama

Sakata

et al. 2016

J of Obstet and Gynaecol

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“…In summary, radical abdominal trachelectomy is one option as a fertility sparing approach for appropriate patients with an invasive cervical cancer. The combined literature, including this series would indicate comparable oncologic outcomes to that of radical hysterectomy and acceptable fertility rates and should be considered in appropriately selected patients, however, longer follow up and more clinical studies are needed to confirm this 4,14 …”

Section: Discussionmentioning

confidence: 76%

“…Whilst only a small case series of four patients, it represents the only reported Australian experience in the literature of pure radical abdominal trachelectomy. It adds to a relatively small number of international reports on radical abdominal trachelectomy 4–14 …”

Section: Discussionmentioning

confidence: 99%

A personal experience with radical abdominal trachelectomy for the conservative management of invasive cervical cancer

Carter

Smirnova

2011

Australian and New Zealand Journal of Obstetrics and Gynaecology

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“…The literature search yielded a total of 937 studies, of which 355 duplicates were removed; 582 titles were screened against our inclusion criteria, and 452 abstracts were fully assessed. Of those abstracts, 130 full texts were scrutinised, and 51 failed to meet the inclusion criteria, leaving 79 studies for inclusion in our analysis 25,38–115 . Additionally, the literature search yielded several systematic reviews, which were manually assessed, and we identified a further 25 studies not captured by the initial literature search 26,116–139 …”

Section: Resultsmentioning

confidence: 99%

Variation in outcome reporting in studies of fertility‐sparing surgery for cervical cancer: A systematic review

Yong

Cooper

Yorke

et al. 2022

BJOG

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Background: Cervical cancer affects 3197 women in the UK, and 604 000 women worldwide annually, with peak incidence seen in women between 30 and 34 years of age. For many, fertility-sparing surgery is an appealing option where possible. However, absence of large-scale data, along with a notable variation in reported outcomes in relevant studies, may undermine future efforts for consistent evidence synthesis. Objectives: To systematically review the reported outcomes measured in studies that include women who underwent fertility-sparing surgery for cervical cancer and identify whether variation exists. Search strategy: We searched MEDLINE, EMBASE and CENTRAL from inception to February 2019. Selection criteria: Randomised controlled trials, cohort and observational studies, and case studies of more than ten participants from January 1990 to date. Data collection and analysis: Study characteristics and all reported treatment outcomes. Main results: A total of 104 studies with a sum of 9535 participants were identified. Most studies reported on oncological outcomes (97/104), followed by fertility and pregnancy (86/104), postoperative complications (74/104), intra-operative complications (72/104) and quality of life (5/104). There was huge variation and heterogeneity in reported outcomes, with only 12% being good quality and 87% being of poor quality. Conclusions: There is significant heterogeneity in the reported outcomes. An agreed Core Outcome Set is necessary for future studies to effectively harmonise reported outcomes that are measurable and relevant to patients, clinicians and researchers. This systematic review sets the groundwork for the development of a Core Outcome Set for fertility-sparing surgery in cervical cancer.

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The functional reconstruction of fertility-sparing radical abdominal trachelectomy for early stage cervical carcinoma

Cited by 26 publications

References 11 publications

Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience

Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience

A personal experience with radical abdominal trachelectomy for the conservative management of invasive cervical cancer

Variation in outcome reporting in studies of fertility‐sparing surgery for cervical cancer: A systematic review

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