The Functional, Metabolic, and Anabolic Responses to Exercise Training in Renal Transplant and Hemodialysis Patients

Ham, E.C.H. van den; Kooman, Jeroen P.; Schols, A.M.W.J.; Nieman, Fred; Does, Joan D; Akkermans, Marco A.; Janssen, Paul P.; Gosker, Harry R.; Ward, Ken; Macdonald, Jamie; Christiaans, Maarten H. L.; Leunissen, Karel M.L.; Hooff, J. P. van

doi:10.1097/01.tp.0000259552.55689.fd

Cited by 59 publications

(45 citation statements)

References 53 publications

(84 reference statements)

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“…These results reemphasize the need for additional interventions, such as exercise training, to increase PA parameters both before and after the start of dialysis, which has been shown to be beneficial in this patient group by several studies [32,33] , and furthermore to investigate whether or not such interventions are beneficial in the long term, given the fact that no differences in PA parameters were found between the CKD-5 non-dialysis group and the dialysis group. This underlines that the positive effect of starting dialysis is possibly cancelled out by a prolonged time on dialysis.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity in End-Stage Renal Disease Patients: The Effects of Starting Dialysis in the First 6 Months after the Transition Period

Broers

Martens

Cornelis

et al. 2017

Nephron

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Objectives: Physical inactivity in end-stage renal disease (ESRD) patients is associated with increased mortality, and might be related to abnormalities in body composition (BC) and physical performance. It is uncertain to what extent starting dialysis influences the effects of ESRD on physical activity (PA). This study aimed to compare PA and physical performance between stage 5 chronic kidney disease (CKD-5) non-dialysis and dialysis patients, and healthy controls, to assess alterations in PA during the transition from CKD-5 non-dialysis to dialysis, and to relate PA to BC. Methods: For the cross-sectional analyses 44 CKD-5 non-dialysis patients, 29 dialysis patients, and 20 healthy controls were included. PA was measured by the SenseWear™ pro3. Also, the walking speed and handgrip strength (HGS) were measured. BC was measured by the Body Composition Monitor©. Longitudinally, these parameters were assessed in 42 CKD-5 non-dialysis patients (who were also part of the cross-sectional analysis), before the start of dialysis and 6 months thereafter. Results: PA was significantly lower in CKD-5 non-dialysis patients as compared to that in healthy controls but not as compared to that in dialysis patients. HGS was significantly lower in dialysis patients as compared to that in healthy controls. Walking speed was significantly lower in CKD-5 non-dialysis patients as compared to that in healthy controls but not as compared to that in dialysis patients. Six months after starting dialysis, activity related energy expenditure (AEE) and walking speed significantly increased. Conclusions: PA is already lower in CKD-5 non-dialysis patients as compared to that in healthy controls and does not differ from that of dialysis patients. However, the transition phase from CKD-5 non-dialysis to dialysis is associated only with a modest improvement in AEE.

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Section: Discussionmentioning

confidence: 99%

Physical Activity in End-Stage Renal Disease Patients: The Effects of Starting Dialysis in the First 6 Months after the Transition Period

Broers

Martens

Cornelis

et al. 2017

Nephron

Self Cite

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“…A vastus lateralis biopsy was taken from the six best male runners in a larger RTx group after training (144 However, these abnormalities are not always found. Although muscle strength and peak incremental exercise performance were reduced in RTx in the study by van den Ham et al in 2007, no evidence of muscle abnormalities was evident in the variables measured (312). Muscle fiber type composition did not differ between 25 RTx and controls for Type I, IIa, or IIx fibers (RTx, 31.6 ± 5.6%, 46.5 ± 7.3%, 21.9 ± 10.4%; controls 34.5 ± 6.8, 44.8 ± 7.9, 20.7 ± 10.7%,, respectively) (312).…”

Section: Studies Of Peripheral Skeletal Muscle In Renal Transplantationmentioning

confidence: 47%

Exercise Limitation Following Transplantation

Williams

McKenna

2012

Comprehensive Physiology

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Organ transplantation is one of the medical miracles or the 20th century. It has the capacity to substantially improve exercise performance and quality of life in patients who are severely limited with chronic organ failure. We focus on the most commonly performed solid‐organ transplants and describe peak exercise performance following recovery from transplantation. Across all of the common transplants, evaluated significant reduction in o 2 peak is seen (typically renal and liver 65%‐80% with heart and/or lung 50%‐60% of predicted). Those with the lowest o 2 peak pretransplant have the lowest o 2 peak posttransplant. Overall very few patients have a o 2 peak in the normal range. Investigation of the cause of the reduction of o 2 peak has identified many factors pre‐ and posttransplant that may contribute. These include organ‐specific factors in the otherwise well‐functioning allograft (e.g., chronotropic incompetence in heart transplantation) as well as allograft dysfunction itself (e.g., chronic lung allograft dysfunction). However, looking across all transplants, a pattern emerges. A low muscle mass with qualitative change in large exercising skeletal muscle groups is seen pretransplant. Many factor posttransplant aggravate these changes or prevent them recovering, especially calcineurin antagonist drugs which are key immunosuppressing agents. This results in the reduction of o 2 peak despite restoration of near normal function of the initially failing organ system. As such organ transplantation has provided an experiment of nature that has focused our attention on an important confounder of chronic organ failure‐skeletal muscle dysfunction. © 2012 American Physiological Society. Compr Physiol 2:1937‐1979, 2012.

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“…La réhabilitation multimodale pourrait aussi être bénéfique dans d'autres maladies chroniques. Chez les patients transplantés pulmonaires pour insuffisance respiratoire chronique, les insuffisants rénaux et le diabète de type 2, la réhabilitation multimodale est associée à l'amélioration du métabolisme musculaire oxydatif [80][81][82] et à une meilleure survie [71]. Des programmes de soins spécifiques incluant l'exercice physique pourraient retarder la progression de l'atrophie musculaire chez les patients insuffisants cardiaques chroniques [83,84].…”

Section: La Réhabilitation Respiratoire Le Traitement De Base De La unclassified

Réhabilitation respiratoire dans la broncho-pneumopathie chronique obstructive (BPCO) : l’androgénothérapie, pourquoi ? Pour qui ? Comment ?

Thibault

Samaras

et al. 2016

Nutrition Clinique et Métabolisme

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Résumé L'insuffisance respiratoire chronique obstructive secondaire à la broncho-pneumopathie chronique obstructive (BPCO) combine les effets délétères de l'hypoxie chronique, l'inflammation chronique, l'insulinorésistance, l'augmentation de la dépense énergétique, la fonte musculaire, et le déconditionnement à l'exercice. Comme pour d'autres maladies chroniques, la perte de masse non grasse diminue la survie. Préserver la masse et la fonction musculaires en maintenant le métabolisme mitochondrial oxydatif est un point clé de la prise en charge du patient BPCO. Du fait du vieillissement de la population, de l'augmentation de prévalence de la BPCO et du progrès médical, les années futures vont connaître l'augmentation de la prévalence de la dénutrition chez les patients BPCO. L'androgénopénie, ou l'hypogonadisme, définie par une testostéronémie libre inférieure à 50 pg/mL, est observée chez 40 % des patients BPCO. Comme les androgènes stimulent l'anabolisme musculaire, l'androgénopénie s'associe à une fonte musculaire. Des études, dont une récente méta-analyse, indiquent que l'androgénothérapie pouvait augmenter l'indice de masse corporelle et la masse non grasse, ainsi que la qualité de vie des patients BPCO, mais, seule, était insuffisante pour améliorer la fonction respiratoire. Deux essais randomisés multicentriques ont démontré que l'association androgénothérapie-exercice physique-compléments nutritionnels oraux contenant des acides gras poly-insaturés oméga-3, pendant au moins trois mois, diminuait la morbi-mortalité. Ce traitement multimodal est optimisé dans le cadre de la réhabilitation respiratoire, qui est le traitement de référence de la dénutrition du patient BPCO. © 2016 Elsevier Masson SAS. Tous droits réservés.Mots clés : Dénutrition ; Insuffisance respiratoire ; Activité physique ; Compléments nutritionnels oraux ; Nutrition AbstractChronic obstructive pulmonary disease (COPD) combines the deleterious effects of chronic hypoxia, chronic inflammation, insulin-resistance, increased energy expenditure, muscle wasting, and exercise deconditioning. As for other chronic disorders, loss of fat-free mass decreased survival. The preservation of muscle mass and function, through the protection of the mitochondrial oxidative metabolism, is an important challenge in the management of COPD patients. As the prevalence of the disease is increasing and the medical advances make COPD patients live longer, the prevalence of COPD-associated nutritional disorders is expected to augmentation in future decades. Androgenopenia, or hypogonadism, defined by free testosterone plasma concentrations below 50 pg/mL, is observed in 40% of COPD patients. Due to the stimulating effects of androgens on muscle anabolism, androgenopenia favors loss of muscle mass. Studies, including one recent meta-analysis, indicate that androgen substitution * Auteur correspondant. R. Thibault et al. / Nutrition clinique et métabolisme 30 (2016) 74-82 75 could improve body mass index and fat-free mass as well as quality of life in COPD pa...

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The Functional, Metabolic, and Anabolic Responses to Exercise Training in Renal Transplant and Hemodialysis Patients

Cited by 59 publications

References 53 publications

Physical Activity in End-Stage Renal Disease Patients: The Effects of Starting Dialysis in the First 6 Months after the Transition Period

Physical Activity in End-Stage Renal Disease Patients: The Effects of Starting Dialysis in the First 6 Months after the Transition Period

Exercise Limitation Following Transplantation

Réhabilitation respiratoire dans la broncho-pneumopathie chronique obstructive (BPCO) : l’androgénothérapie, pourquoi ? Pour qui ? Comment ?

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