The functional IGFBP7 promoter −418G&gt;A polymorphism and risk of head and neck cancer

Huang, Yu; Niu, Jiangong; Liu, Zhensheng; Wang, Li E.; Wei, Qingyi

doi:10.1016/j.mrgentox.2010.06.012

Cited by 11 publications

(6 citation statements)

References 37 publications

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“…DNA methylation was regarded as the main mechanism in abnormal expression of IGFBP7 25 . In 2010, Huang et al 33 found the SNPs in the promoter-regulatory region might affect the gene expression level and modify the cancer susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Serum IGFBP7 levels associate with insulin resistance and the risk of metabolic syndrome in a Chinese population

Liu

Ling

et al. 2015

Sci Rep

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Metabolic syndrome (MetS), one of the major public health concerns, is regarded as the “common soil” of incidence of common chronic diseases and may increase the risk of type 2 diabetes. The predominant underlying mechanism of MetS is insulin resistance (IR). Additionally, previous studies have indicated that IGFBP7 has high affinity of binding with insulin and might induce IR. The objective of this study was to firstly evaluate the associations of serum IGFBP7 levels with IR and MetS with a relatively large sample and population based design. In a population based MetS case-control study, HOMA-IR was used to evaluate the insulin sensitivity and serum IGFBP7 levels were determined with chemiluminescence–linked immunoassay. As a result, the subjects of MetS and IR had higher serum levels of IGFBP7 than control healthy subjects. High serum IGFBP7 levels increased the risk of MetS and IR. Serum IGFBP7 levels were also found to be significantly correlated with metabolic-associated parameters of Waist-to-hip ratio (WHR), HDL and LDL. These findings suggest that serum IGFBP7 levels are associated with IR and MetS, providing new insight into the mechanism of IR and Mets. IGFBP7 may be a potential interventional target for IR and Mets.

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Section: Discussionmentioning

confidence: 99%

Serum IGFBP7 levels associate with insulin resistance and the risk of metabolic syndrome in a Chinese population

Liu

Ling

et al. 2015

Sci Rep

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“…Participant recruitment was described previously [33, 35, 36]. Briefly, all patients with histopathologically confirmed SCCHN were consecutively recruited from The University of Texas M.D.…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck

Liu³

et al. 2012

Pharmacogenetics and Genomics

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Objectives Xeroderma pigmentosum group G (XPG) protein is essential for the nucleotide excision repair (NER) system, and genetic variations in XPG/ERCC5 that affect DNA repair capacity may contribute to the risk of tobacco-induced cancers, including squamous cell carcinoma of the head and neck (SCCHN). We investigated the association between XPG/ERCC5 polymorphisms and risk of squamous cell carcinoma of the head and neck (SCCHN). Methods We genotyped 12 tagging and potentially functional single nucleotide polymorphisms (SNPs) of XPG/ERCC5 in a case-control study of 1,059 non-Hispanic white patients with SCCHN and 1,066 cancer-free age-and sex matched controls and evaluated their associations with SCCHN risk. Results Multivariate logistic regression showed that only an intronic tagging SNP (rs4150351A/C) of XPG/ERCC5 was associated with a decreased risk of SCCHN (adjusted OR=0.76, 95% CI=0.62–0.92 for AC vs. AA; adjusted OR=0.81, 95% CI=0.67–0.98 for AC/CC vs. AA), but this association was nonsignificnant after corrections by the permutation test (empirical P=0.105). In the genotype-phenotype correlation analysis using peripheral lymphocytes from 44 SCCHN patients, we found that rs4150351 AC/CC was associated with a statistically significant increase in XPG/ERCC5 mRNA expression. Conclusion These findings suggest that genetic variation in XPG/ERCC5 may not affect the SCCHN risk, although rs4150351 C variant genotypes were associated with the increased expression of XPG/ERCC5 mRNA and nonsignificantly decreased risk of SCCHN. Larger population-based and additional functional studies are warranted to validate our findings.

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“…Participant recruitment has been described elsewhere [ 20 , 21 ]. In brief, newly-diagnosed SCCHN cancer patients were consecutively recruited from The University of Texas M.D.…”

Section: Methodsmentioning

confidence: 99%

Association between novel PLCE1variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck

Wang

Liu

et al. 2011

BMC Cancer

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BackgroundPhospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase family plays crucial roles in carcinogenesis and progression of several cancers, including squamous cell carcinoma of the head and neck (SCCHN). A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus in genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) that share similar risk factors with SCCHN. Therefore, we investigated the association between potentially functional SNPs in PLCE1 and susceptibility to SCCHN.MethodsWe genotyped three potentially functional SNPs (rs2274223A/G, rs3203713A/G and rs11599672T/G) of PLCE1 in 1,098 SCCHN patients and 1,090 controls matched by age and sex in a non-Hispanic white population.ResultsAlthough none of three SNPs was alone significantly associated with overall risk of SCCHN, their combined effects of risk alleles (rs2274223G, rs3203713G and rs11599672G) were found to be associated with risk of SCCHN in a locus-dose effect manner (Ptrend = 0.046), particularly for non-oropharyngeal tumors (Ptrend = 0.017); specifically, rs2274223 was associated with a significantly increased risk (AG vs. AA: adjusted OR = 1.29, 95% CI = 1.01-1.64; AG/GG vs. AA: adjusted OR = 1.30, 95% CI = 1.03-1.64), while rs11599672 was associated with a significantly decreased risk (GG vs. TT: adjusted OR = 0.54, 95% CI = 0.34-0.86; TG/GG vs. TT: adjusted OR = 0.76, 95% CI = 0.61-0.95).ConclusionsOur findings suggest that PLCE1 variants may have an effect on risk of SCCHN associated with tobacco and alcohol exposure, particularly for those tumors arising at non-oropharyngeal sites. These findings, although need to be validated by larger studies, are consistent with those in esophageal and gastric cancers.

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The functional IGFBP7 promoter −418G>A polymorphism and risk of head and neck cancer

Cited by 11 publications

References 37 publications

Serum IGFBP7 levels associate with insulin resistance and the risk of metabolic syndrome in a Chinese population

Serum IGFBP7 levels associate with insulin resistance and the risk of metabolic syndrome in a Chinese population

Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck

Association between novel PLCE1variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck

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