The functional evaluation of waste yuzu (Citrus junos) seeds

Minamisawa, Mayumi; Yoshida, Shöichirö; Uzawa, Atsushi

doi:10.1039/c3fo60440c

Cited by 21 publications

(17 citation statements)

References 33 publications

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“…Bonaccorsi and co-workers [77,78] have reported that lemon and orange seeds contain as many limonoids as 375 and 114 mg/kg, respectively. These values were by far lower than those reported for lemon and orange seeds (18.93 and 22.33 mg/g dry seed, respectively) by other authors [79]. Noteworthy, a labor-intensive sample preparation protocol followed in the latter study probably resulted in higher extraction yields.…”

Section: Citrus Seedscontrasting

confidence: 68%

The Potential of Tree Fruit Stone and Seed Wastes in Greece as Sources of Bioactive Ingredients

2018

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The inedible part (stones, husks, kernels, seeds) of the tree fruits that are currently processed in various regions of Greece constitutes a huge portion of the fruit processing solid waste that remains underexploited. In this review, the existing scientific background for the composition and content of fruit stone and seed in bioactive ingredients is highlighted for olives, stone fruits and citrus fruits that represent the economically most important tree crop products of the country. The content of bioactive compounds may vary considerably depending on the quality of the raw material and the treatment during processing. However, both the hydrophilic and the lipophilic fractions of the seeds contain significant amounts of the primary and the secondary plant metabolites. Among them, phytosterols and several types of polyphenols, but also squalene, tocopherols and some other terpenoids with a unique structure are of particular importance for the utilization and valorization of stones and seeds. Official and scholar records about the current management practices are also presented to highlight the dynamics of the Greek fruit sector. Prospects for the regionalization of fruit seed wastes, in line with EU-promoted Research and Innovation Strategies (RIS) for Smart Specialization are critically discussed.

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Section: Citrus Seedscontrasting

confidence: 68%

The Potential of Tree Fruit Stone and Seed Wastes in Greece as Sources of Bioactive Ingredients

2018

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“…By using reversed-phase HPLC and LC-MS, four limonoid aglycones (1-4) and seven limonoid glucosides; 11-14, 49, 50, and ichangin glucoside (51, Figure 16) of the limonin group were identified from the yuzu seed extracts. Their amounts were found to be higher than those found in other citrus fruits [168]. The isolation and identification of both limonoids aglycones and glucosides by routinary HPLC and spectrometric or spectroscopic analyses is reported in several recent papers [48,52,169].…”

Section: Limonoid Aglycones and Glucosidesmentioning

confidence: 99%

“…In general, when compared to other citrus juices, the limonoid glucoside content in the sour orange juices is much lower than that of sweet oranges and, among the limonoid glucosides present, nomilin related glucosides, 13, 14, and deacetylnomilin 17-β-D-glucoside (50), were predominant [167]. Finally, in a project aimed at using renewable natural resources, Minamisawa et al [168] proposed in 2014 the extraction of large amounts of limonoids from waste yuzu (C. junos) seeds. By using reversed-phase HPLC and LC-MS, four limonoid aglycones (1-4) and seven limonoid glucosides; 11-14, 49, 50, and ichangin glucoside (51, Figure 16) of the limonin group were identified from the yuzu seed extracts.…”

Section: Limonoid Aglycones and Glucosidesmentioning

confidence: 99%

“…Actually, only 1, obacunone (3), and deoxylimonin (10) were used in the last decade as starting materials to obtain few related derivatives. Improved large-scale extraction methodologies and the abundantly available waste citrus materials [23,168,169,195] should allow easier access to starting materials in the future. Then, ligand efficiency metrics (LEM) guided derivatization of the latter should furnish new CL analogues to prove the reliability of CLs as defenders and promoters of human health.…”

Section: General Summary and Conclusionmentioning

confidence: 99%

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The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.

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“…Citros junos fruit extract, known as yuzu, provides an important dietary source of anti-oxidant compounds with rich polyphenol and limonoid contents [82], and it has also anti-inflammatory properties [83,84].…”

Section: Discussionmentioning

confidence: 99%

Thermosensitive Hydrogel Mask Significantly Improves Skin Moisture and Skin Tone; Bilateral Clinical Trial

2017

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Objective: A temperature-sensitive state-changing hydrogel mask was used in this study. Once it comes into contact with the skin and reaches the body temperature, it uniformly and quickly releases the active compounds, which possess moisturizing, anti-oxidant, anti-inflammatory and regenerative properties. Methods: An open label clinical trial was conducted to evaluate the effects of the test product on skin hydration, skin tone and skin ageing. Subjects applied the product to one side of their face and underwent Corneometer ® and Chromameter measurements, Visual assessment of facial skin ageing and facial photography. All assessments and Self-Perception Questionnaires (SPQ) were performed at baseline, after the first application of the test product and after four applications. Results: After a single treatment we observed an increase in skin moisturisation, an improvement of skin tone/luminosity and a reduction in signs of ageing, all statistically significant. After four applications a further improvement in all measured parameters was recorded. These results were confirmed by the subjects' own perceptions, as reported in the SPQ both after one and four applications. Conclusion: The hydrogel mask tested in this study is very effective in improving skin hydration, skin radiance and luminosity, in encouraging an even skin tone and in reducing skin pigmentation.

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The functional evaluation of waste yuzu (Citrus junos) seeds

Cited by 21 publications

References 33 publications

The Potential of Tree Fruit Stone and Seed Wastes in Greece as Sources of Bioactive Ingredients

The Potential of Tree Fruit Stone and Seed Wastes in Greece as Sources of Bioactive Ingredients

The Chemistry and Pharmacology of Citrus Limonoids

Thermosensitive Hydrogel Mask Significantly Improves Skin Moisture and Skin Tone; Bilateral Clinical Trial

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