The Functional Effects of Contrast Media on the Isolated Perfused Rat Kidney

Pw, Brown; Jl, Haylor; Nahas, el; Sk, Morcos

doi:10.1159/000422137

Cited by 9 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although this difference was not statistically significant, the patients who received furosemide infusions did experience brisk diuresis and it is considered likely that the magnitude of the fluid loss posed some difficulty for the nursing staff in regard to the administration of replacement fluid. In addition, radiocontrast material, since it has significant osmotic activity itself, can promote a substantial osmotic diuresis without the use of an additional diuretic [15]. Further, replacement of high urinary flow rates were performed reluctantly by staff who were aware of the fact that the patients involved had histories of serious underlying ischemic myocardial disease and congestive heart failure.…”

Section: Discussionmentioning

confidence: 99%

Negative fluid balance and the occurrence of radiocontrast associated acute renal failure

Pfaffle

Moses

Chan

et al. 1994

Geriatric Nephrol Urol

View full text Add to dashboard Cite

The factors that influence the occurrence and course of radiocontrast associated acute renal failure (RAARF) were evaluated in ten elderly patients who developed postcardiac catheterization renal failure following the use of low osmolar (iohexol) radiocontrast material. Data from these patients was compared to that of ten similar patients who did not develop RAARF. Mean ages (73 -4-1.2 vs. 72 4-1.7 years, p > 0.05), and baseline serum creatinines (1.7 -4-0.1 vs. 1.8 -4-0.1 mg/dl, p > 0.05), were not different. The amount of contrast material administered was similar in both groups. Mean fluid balance in patients with RAARF was negative 571 -4-107 ml on the study day, while patients without RAARF were positive 707 -4-222 ml (p < 0.05). There were no significant differences between either group in regard to concomitant medications, or associated diseases. Also, no significant differences between the prophylactic use of furosemide infusion or the occurrence of diabetes mellitus were observed in either group. There was, however, an increased risk for RAARF in patients with diabetes mellitus who also developed negative fluid balance (p < 0.05). The data suggest that negative fluid balance of relatively small degree (500 ml) in association with the administration of radiocontrast material may be a major factor in the development of RAARE

show abstract

Section: Discussionmentioning

confidence: 99%