The functional cross talk between cancer cells and cancer associated fibroblasts from a cancer mechanics perspective

Ansardamavandi, Arian; Tafazzoli-Shadpour, Mohammad

doi:10.1016/j.bbamcr.2021.119103

Cited by 27 publications

(24 citation statements)

References 294 publications

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“…Could the increased contractile force generation likely by downstream targets regulated by MRTFs contribute to increased decidual resistance to trophoblast invasion? Although, contractile force generation by cancer associated fibroblasts has been shown to be critical in inducing dissemination of epithelial cancer ( Ansardamavandi and Tafazzoli-Shadpour, 2021 ), the actual response of collective fibroblast activation in a wound, or in response to decidualization, in resisting epithelial invasion is not well understood. Both epithelial-fibroblast coupling via N- and E-Cadherin heterotypic adhesion ( Labernadie et al, 2017 ), as well as the collective directionality of force presentation against the invading front because of remodeled matrix may contribute to the process of stromal resistance ( Erdogan and Webb, 2017 ; Asif et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

“…Recent decade has increased our appreciation of the role of cancer associated fibroblasts in abetting tumor dissemination, but it is not yet clear whether fibroblasts assist, or resist cancer invasion, as evidence point to either scenario. It is however recognized that cancer cells themselves can prime stromal fibroblasts, incorporating them to facilitate stromal invasion ( Ansardamavandi and Tafazzoli-Shadpour, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Fibroblast activation generically results in increased actomyosin assembly and force generation, followed by remodeling of the extracellular matrix. Contractile force generation by fibroblasts, when coupled with fibroblast-epithelium interaction, is now understood to be important in instigating dissemination of epithelial tumors ( Labernadie et al, 2017 ; Ansardamavandi and Tafazzoli-Shadpour, 2021 ). However, contractile forces may also be resistive ( Wang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Paracrine HB-EGF signaling reduce enhanced contractile and energetic state of activated decidual fibroblasts by rebalancing SRF-MRTF-TCF transcriptional axis

Afzal

Du²,

Novin³

et al. 2022

Front. Cell Dev. Biol.

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Multiple parallels exist between placentation and cancer dissemination at molecular, cellular, and anatomical levels, presenting placentation as a unique model to mechanistically understand the onset of cancer metastasis. In humans, interaction of placenta and the endometrium results eventually in deep invasion of placental extravillous trophoblasts (EVTs) into the maternal stroma, a process similar to stromal trespass by disseminating carcinoma cells. In anticipation of implantation, endometrial fibroblasts (ESFs) undergo a process called decidualization during the secretory phase of the menstrual cycle. Decidualization, among other substantial changes associated with ESF differentiation, also involves a component of fibroblast activation, and myofibroblast transformation. Here, using traction force microscopy, we show that increased cellular contractility in decidualized ESFs is reversed after interaction with EVTs. We also report here the large changes in energetic state of ESFs upon decidualization, showing increased oxidative phosphorylation, mitochondrial competency and ATP generation, as well as enhanced aerobic glycolysis, presenting mechanical contractility and energetic state as new functional hallmarks for decidualization. These energetic changes accompanying the marked increase in contractile force generation in decidualization were reduced in the presence of EVTs. We also show that increase in decidual contractility and mechanical resistance to invasion is achieved by SRF-MRTF transcriptional activation, achieved via increased phosphorylation of fibroblast-specific myosin light chain 9 (MYL9). EVT induced paracrine secretion of Heparin Binding Epidermal Growth Factor (HBEGF), a potent MAPK activator, which shifts the balance of SRF association away from MRTF based transcription, reducing decidual ESF contractility and mechanical resistance to placental invasion. Our results identify a new axis of intercellular communication in the placental bed modulating stromal force generation and resistance to invasion with concurrent downregulation of cellular energetics. These findings have important implications for implantation related disorders, as well as stromal control of cancer dissemination.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Paracrine HB-EGF signaling reduce enhanced contractile and energetic state of activated decidual fibroblasts by rebalancing SRF-MRTF-TCF transcriptional axis

Afzal

Du²,

Novin³

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…The degradation of the ECM is considered an important marker of the progress of metastasis [13,14,[44][45][46]. Numerous previous studies have revealed that this process is catalyzed by proteins secreted by cancer cells and allows cancer cells to migrate to other tissues or organs [17].…”

Section: Discussionmentioning

confidence: 99%

The Inhibitory Effects of Terminalia catappa L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells

Chung

Hsieh

et al. 2021

Pharmaceuticals

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Glioblastoma multiforme (GBM) is one of the most aggressive and common types of brain tumor. Due to its high proliferation ability, a high lethality rate has been observed with this malignant glial tumor. Terminalia catappa L. (T. catappa) is currently known to have anti-inflammatory and anti-carcinogenesis effects. However, few studies have examined the mechanisms of the leaf extracts of T. catappa (TCE) on GBM cells. In the current study, we demonstrated that TCE can significantly inhibit the migration and invasion capabilities of GBM cell lines without showing biotoxic effects. Matrix metalloproteinases-2 (MMP-2) activity and protein expression were attenuated by reducing the p38 phosphorylation involved in the mitogen-activated protein kinase (MAPK) pathway. By treating with TCE and/or p38 inhibitor (SB203580), we confirmed that p38 MAPK is involved in the inhibition of cell migration. In conclusion, our results demonstrated that TCE inhibits human GBM cell migration and MMP-2 expression by regulating the p38 pathway. These results reveal that TCE contains potent therapeutic compounds which could be applied for treating GBM brain tumors.

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“…1 There are different types of CAFs arising from the activation, differentiation and transdifferentiation of other cell types. 7 CAFs recruitment in tumor site is a crucial step which contributes to cancer cells invasion and subsequent tumor promotion. Various ECM factors are implicated in CAFs motility and their migration towards cancer cells, including HA.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan as “Agent Smith” in cancer extracellular matrix pathobiology: Regulatory roles in immune response, cancer progression and targeting

et al. 2022

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Extracellular matrix (ECM) critically regulates cancer cell behavior by governing cell signaling and properties. Hyaluronan (HA) acts as a structural and functional ECM component that mediates critical properties of cancer cells in a molecular size‐dependent manner. HA fragments secreted by cancer‐associated fibroblasts (CAFs) reveal the correlation of HA to CAF‐mediated matrix remodeling, a key step for the initiation of metastasis. The main goal of this article is to highlight the vital functions of HA in cancer cell initiation and progression as well as HA‐mediated paracrine interactions among cancer and stromal cells. Furthermore, the HA implication in mediating immune responses to cancer progression is also discussed. Novel data on the role of HA in the formation of pre‐metastatic niche may contribute towards the improvement of current theranostic approaches that benefit cancer management.

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The functional cross talk between cancer cells and cancer associated fibroblasts from a cancer mechanics perspective

Cited by 27 publications

References 294 publications

Paracrine HB-EGF signaling reduce enhanced contractile and energetic state of activated decidual fibroblasts by rebalancing SRF-MRTF-TCF transcriptional axis

Paracrine HB-EGF signaling reduce enhanced contractile and energetic state of activated decidual fibroblasts by rebalancing SRF-MRTF-TCF transcriptional axis

The Inhibitory Effects of Terminalia catappa L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells

Hyaluronan as “Agent Smith” in cancer extracellular matrix pathobiology: Regulatory roles in immune response, cancer progression and targeting

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