The functional consequences of chronic, physiologically effective intracortical microstimulation

Parker, Rebecca; Davis, Tyler; House, Paul; Normann, Richard A.; Greger, Bradley

doi:10.1016/b978-0-444-53815-4.00010-8

Cited by 42 publications

(56 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However significant variations in spike waveforms across time have been reported (Parker et al, 2011). These variations could reflect the initial acute response that can lead to chronic inflammatory reactions.…”

Section: Electrophysiological Recordingsmentioning

confidence: 99%

Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects

et al. 2014

Self Cite

View full text Add to dashboard Cite

The emerging field of neuroprosthetics is focused on the development of new therapeutic interventions that will be able to restore some lost neural function by selective electrical stimulation or by harnessing activity recorded from populations of neurons. As more and more patients benefit from these approaches, the interest in neural interfaces has grown significantly and a new generation of penetrating microelectrode arrays are providing unprecedented access to the neurons of the central nervous system (CNS). These microelectrodes have active tip dimensions that are similar in size to neurons and because they penetrate the nervous system, they provide selective access to these cells (within a few microns). However, the very long-term viability of chronically implanted microelectrodes and the capability of recording the same spiking activity over long time periods still remain to be established and confirmed in human studies. Here we review the main responses to acute implantation of microelectrode arrays, and emphasize that it will become essential to control the neural tissue damage induced by these intracortical microelectrodes in order to achieve the high clinical potentials accompanying this technology.

show abstract

Section: Electrophysiological Recordingsmentioning

confidence: 99%

Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…We then measured the degree to which animals could discriminate pairs of ICMS pulse trains that differed in amplitude. In both the detection and discrimination experiments, ICMS parameters-amplitude, pulse width, pulse train duration, and pulse train frequency-spanned the range that is detectable and has been typically deemed safe (12)(13)(14). Results from the present experiments will inform the design of future studies involving ICMS as well as the development of sensory encoding algorithms for neuroprostheses.…”

mentioning

confidence: 96%

Behavioral assessment of sensitivity to intracortical microstimulation of primate somatosensory cortex

Kim

Callier

Tabot

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

122

132

View full text Add to dashboard Cite

Intracortical microstimulation (ICMS) is a powerful tool to investigate the functional role of neural circuits and may provide a means to restore sensation for patients for whom peripheral stimulation is not an option. In a series of psychophysical experiments with nonhuman primates, we investigate how stimulation parameters affect behavioral sensitivity to ICMS. Specifically, we deliver ICMS to primary somatosensory cortex through chronically implanted electrode arrays across a wide range of stimulation regimes. First, we investigate how the detectability of ICMS depends on stimulation parameters, including pulse width, frequency, amplitude, and pulse train duration. Then, we characterize the degree to which ICMS pulse trains that differ in amplitude lead to discriminable percepts across the range of perceptible and safe amplitudes. We also investigate how discriminability of pulse amplitude is modulated by other stimulation parameters-namely, frequency and duration. Perceptual judgments obtained across these various conditions will inform the design of stimulation regimes for neuroscience and neuroengineering applications.is an important tool to investigate the functional role of neural circuits (1, 2). In a famous example, microstimulation of neurons in the middle temporal area was found to bias the perceived direction of visual motion stimuli, causally implicating these neurons in the computation of visual motion direction (3). Experiments with ICMS of somatosensory cortex showed that changing the frequency of stimulation elicited discriminable percepts, demonstrating that temporal patterning of cortical responses has perceptual correlates (4). Building on the success of these and other studies, ICMS has been proposed as an approach to restore perception in individuals who have lost it, for example in visual neuroprostheses for the blind (5, 6) or somatosensory neuroprostheses for tetraplegic patients (7-11). In the present study, we sought to characterize the psychometric properties of ICMS delivered to primary somatosensory cortex (S1) across a wide range of stimulation regimes. In psychophysical experiments with Rhesus macaques, we first measured the detectability of ICMS pulse trains and assessed its dependence on a variety of stimulation parameters. We then measured the degree to which animals could discriminate pairs of ICMS pulse trains that differed in amplitude. In both the detection and discrimination experiments, ICMS parameters-amplitude, pulse width, pulse train duration, and pulse train frequency-spanned the range that is detectable and has been typically deemed safe (12-14). Results from the present experiments will inform the design of future studies involving ICMS as well as the development of sensory encoding algorithms for neuroprostheses. ResultsWe trained two monkeys to perform two variants of a twoalternative forced-choice (2AFC) task: a detection task and a discrimination task. In both tasks, the animal was seated in front of a computer monitor that conveyed information about the trial...

show abstract

“…Given the highly invasive surgery required for implantation and the fact that defective arrays cannot be replaced, intracortical interfaces are thus not ready to be deployed clinically. Some evidence suggests that chronic ICMS can cause neuronal loss (McCreery et al, 2010), but it is unclear whether this loss has any functional consequences (Chen et al, 2014; Parker et al, 2011). Furthermore, chronic ICMS does not seem to cause additional damage to the electrodes or the tissue (Chen et al, 2014).…”

Section: Reliability and Safetymentioning

confidence: 99%

Restoring tactile and proprioceptive sensation through a brain interface

Tabot

Kim

Winberry

et al. 2015

Neurobiology of Disease

View full text Add to dashboard Cite

Somatosensation plays a critical role in the dexterous manipulation of objects, in emotional communication, and in the embodiment of our limbs. For upper-limb neuroprostheses to be adopted by prospective users, prosthetic limbs will thus need to provide sensory information about the position of the limb in space and about objects grasped in the hand. One approach to restoring touch and proprioception consists of electrically stimulating neurons in somatosensory cortex in the hopes of eliciting meaningful sensations to support the dexterous use of the hands, promote their embodiment, and perhaps even restore the affective dimension of touch. In this review, we discuss the importance of touch and proprioception in everyday life, then describe approaches to providing artificial somatosensory feedback through intracortical microstimulation (ICMS). We explore the importance of biomimicry – the elicitation of naturalistic patterns of neuronal activation – and that of adaptation – the brain’s ability to adapt to novel sensory input, and argue that both biomimicry and adaptation will play a critical role in the artificial restoration of somatosensation. We also propose that the documented re-organization that occurs after injury does not pose a significant obstacle to brain interfaces. While still at an early stage of development, sensory restoration is a critical step in transitioning upper-limb neuroprostheses from the laboratory to the clinic.

show abstract

The functional consequences of chronic, physiologically effective intracortical microstimulation

Cited by 42 publications

References 55 publications

Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects

Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects

Behavioral assessment of sensitivity to intracortical microstimulation of primate somatosensory cortex

Restoring tactile and proprioceptive sensation through a brain interface

Contact Info

Product

Resources

About