The functional activity of adenylyl cyclase signaling system in the brain, myocardium, and testes of rats with 8- and 18-month neonatal diabetes

Derkach, K. V.; Ao, Shpakov; Moyseuk, I. V.; Chistyakova, O. V.

doi:10.1134/s1607672913010122

Cited by 4 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many neurotransmitters and neurohormones also exert regulatory effects on the biochemical and physiological processes in the CNS and in the periphery via ACSS. It was shown by us and the other authors that the changes in ACSS activity in diabetic tissues correlate positively with severity and duration of DM2 [30–36]. Therefore, the study of ACSS is one of the most promising approaches to be used in the case of DM2 for identification of functional abnormalities in the CNS and the periphery as well as for monitoring dysfunctions in the nervous, cardiovascular, and other systems and for evaluation of the effectiveness of antidiabetic therapy [13, 31, 32, 37].…”

Section: Introductionmentioning

confidence: 95%

The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes

Derkach

Бондарева

Chistyakova

et al. 2015

International Journal of Endocrinology

View full text Add to dashboard Cite

In the last years the treatment of type 2 diabetes mellitus (DM2) was carried out using regulators of the brain signaling systems. In DM2 the level of the brain serotonin is reduced. So far, the effect of the increase of the brain serotonin level on DM2-induced metabolic and hormonal abnormalities has been studied scarcely. The present work was undertaken with the aim of filling this gap. DM2 was induced in male rats by 150-day high-fat diet and the treatment with low dose of streptozotocin (25 mg/kg) on the 70th day of experiment. From the 90th day, diabetic rats received for two months intranasal serotonin (IS) at a daily dose of 20 μg/rat. The IS treatment of diabetic rats decreased the body weight, and improved glucose tolerance, insulin-induced glucose utilization, and lipid metabolism. Besides, it restored hormonal regulation of adenylyl cyclase (AC) activity in the hypothalamus and normalized AC stimulation by β-adrenergic agonists in the myocardium. In nondiabetic rats the same treatment induced metabolic and hormonal alterations, some of which were similar to those in DM2 but expressed to a lesser extent. In conclusion, the elevation of the brain serotonin level may be regarded as an effective approach to treat DM2 and its complications.

show abstract

Section: Introductionmentioning

confidence: 95%

The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes

Derkach

Бондарева

Chistyakova

et al. 2015

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…The DM1 and DM2 are closely associated with severe cardiovascular diseases, such as acute myocardial infarction, congestive heart failure, and atherosclerosis [39,40]. The pathological changes in contractile function of the heart in DM are largely due to impairment of the adrenergic, cholinergic, and purinergic pathways of AC regulation in cardiomyocytes [28,39,[41][42][43][44]. The adrenergic signaling has a very important role in the functioning of the cardiovascular system, and it changes to the greatest extent in DM.…”

Section: The Acss In the Diabetic Heartmentioning

confidence: 99%

“…When the duration of DM2 was 18 months, this effect was reduced as compared with the control group. The stimulating effect of relaxin on AC was reduced in DM2 with different durations, and in 18-months DM2, it did not exceed 46% of that in control [42]. The decrease of effect of guanine nucleotides on AC was shown, indicating a weakening of G s protein function, and one of the causes for this is hyperhomocysteinemia, typical for severe DM2 [54].…”

Section: The Acss In the Diabetic Heartmentioning

confidence: 99%

The Contribution of Changes in Adenylyl Cyclase Signaling System of the Brain and Myocardium to Etiology and Pathogenesis of Diabetes Mellitus

Шпаков¹

2018

Evolutionary Physiology and Biochemistry - Advances and Perspectives

View full text Add to dashboard Cite

The functional changes in hormone-sensitive adenylyl cyclase (AC) signaling system of the central nervous system (CNS) and periphery play a crucial role in etiology and pathogenesis of diabetes mellitus (DM). The identification of these changes in AC signaling system and the abnormalities in AC signaling network are necessary for creation of the new strategies to treat and prevent diabetic pathology. In this chapter, our data and the results of other authors on the changes in hormone-sensitive adenylyl cyclase signaling system (ACSS) in the diabetic brain and heart and on their contribution to etiology and pathogenesis of DM and its complications, diabetic cardiomyopathy in particular, are presented and analyzed, and the promising approaches to treat DM and its complications, which are based on the restoration of AC signaling cascades and their functional interaction, are discussed.

show abstract

The functional activity of hypothalamic signaling systems in rats with neonatal diabetes mellitus treated with metformin

Derkach

Sukhov

Kuznetsova

et al. 2016

Dokl Biochem Biophys

View full text Add to dashboard Cite

The effect of the two-month metformin treatment (200 mg/kg/day) of rats with the neonatal model of type 2 diabetes mellitus on the functional activity of hypothalamic signaling systems was studied. It was shown that metformin treatment restored the sensitivity of hypothalamic adenylyl cyclase signaling system to agonists of the type 4 melanocortin receptor and the type 2 dopamine receptor but did not influence significantly the functions of the insulin signaling system. These data suggest new targets and mechanisms of metformin action in the CNS, which may mediate its restoring effect on energy homeostasis impaired in diabetic pathology.

show abstract

The functional activity of adenylyl cyclase signaling system in the brain, myocardium, and testes of rats with 8- and 18-month neonatal diabetes

Cited by 4 publications

References 13 publications

The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes

The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes

The Contribution of Changes in Adenylyl Cyclase Signaling System of the Brain and Myocardium to Etiology and Pathogenesis of Diabetes Mellitus

The functional activity of hypothalamic signaling systems in rats with neonatal diabetes mellitus treated with metformin

Contact Info

Product

Resources

About