The Function of the Nucleus in the Synthesis of Cytoplasmic Proteins

Brachet, Jean; Chantrenne, Hubert

doi:10.1101/sqb.1956.021.01.026

Cited by 30 publications

(7 citation statements)

References 17 publications

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“…This is supported by biochemical evidence of Osawa, Takata, and Hotta (1957). Although Brachet and Chantrenne (1956) have queried the general occurrence of transfer of RNA formed in the nucleus to the cytoplasm, our evidence is consistent with such transfer. This does not suggest that all cytoplasmic RNA is formed in the nucleus, nor that all nuclear RNA is destined for the cytoplasm.…”

Section: Discussionsupporting

confidence: 71%

“…The simplest hypothesis relating the most constant element in the chromosome-deoxyribonucleic acid (DNA)-to the synthesis of specific proteins is that the DNA directly synthesizes protein; some instances of this are known (Allfrey 1954;Allfrey, Daly, and Mirsky 1955;Allfrey, Mirsky, and Stern 1955;Mirsky 1956). However, in most instances the DNA exerts a less direct influence (Gale and Folkes 1955;Brachet and Chantrenne 1956;Spiegelmann 1956) by way of the intermediary ribonucleic acid (RNA). The earlier correlations between this substance and protein synthesis were pointed out by Caspersson and Brachet.…”

Section: Introduction (A) Nuclear Control Of Protein Synthesismentioning

confidence: 99%

“…Thus where cytoplasmic RNA is involved in protein synthesis, such synthesis is at least indirectly subject to nuclear control, by virtue of the role played by DNA. While "tracer" studies, such as the' nuclear transplant experiments of Goldstein and Plaut (1955) support this nuclear origin, Brachet and Chantrenne (1956) have presented evidence in the alga Acetabularia that RNA can be synthesized in the cytoplasm. Moreover it is not certain that RNA of nuclear origin reaches the cytoplasm unchanged (Goldstein and Plaut 1955).…”

Section: Introduction (A) Nuclear Control Of Protein Synthesismentioning

confidence: 99%

See 2 more Smart Citations

Cell Changes During Protein Synthesis and Secretion: an Electron Microscopic Study of the Response of Lymphoid Tissue to Antigenic Stimulus

Hoffman¹,

Grigg²

1958

Aust. Jnl. Of Bio. Sci.

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Section: Discussionsupporting

confidence: 71%

Section: Introduction (A) Nuclear Control Of Protein Synthesismentioning

confidence: 99%

Section: Introduction (A) Nuclear Control Of Protein Synthesismentioning

confidence: 99%

See 1 more Smart Citation

Cell Changes During Protein Synthesis and Secretion: an Electron Microscopic Study of the Response of Lymphoid Tissue to Antigenic Stimulus

Hoffman¹,

Grigg²

1958

Aust. Jnl. Of Bio. Sci.

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“…Now, we call these adaptors transfer RNAs (tRNAs). tRNAs represent the second class of ncRNAs after ribosome RNAs (rRNAs) [15] . Because both tRNAs and rRNAs assist in translation they are called housekeeping RNAs.…”

Section: Ncrnas: Past and Presentmentioning

confidence: 99%

Genetic regulation by non-coding RNAs

Liwang

Zhang

et al. 2006

SCI CHINA SER C

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Large scale cDNA sequencing and genome tiling array studies have shown that around 50% of genomic DNA in humans is transcribed, of which 2% is translated into proteins and the remaining 98% is non-coding RNAs (ncRNAs). There is mounting evidence that these ncRNAs play critical roles in regulating DNA structure, RNA expression, protein translation and protein functions through multiple genetic mechanisms, and thus affect normal development of organisms at all levels. Today, we know very little about the regulatory mechanisms and functions of these ncRNAs, which is clearly essential knowledge for understanding the secret of life. To promote this emerging research subject of critical importance, in this paper we review (1) ncRNAs' past and present, (2) regulatory mechanisms and their functions, (3) experimental strategies for identifying novel ncRNAs, (4) experimental strategies for investigating their functions, and (5) methodologies and examples of the application of ncRNAs.

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“…Os RNAs também são formados por quatro nucleotídeos (lembrando que a timina (T) é substituída pela uracila (U)) e apresentam-se em sua maioria como uma molécula de fita simples com estrutura indefinida. Brachet [Brachet (1956) ou realizando modificações químicas como metilações em RNA ribossômicos (smRNAs).…”

Section: Rna __________________________________________________________unclassified

Bioinformática estrutural de proteínas modificadas por eventos de splicing alternativo

Durham¹

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Gostaria de agradecer ao meu orientador Sandro de Souza pelo apoio na minha vinda à São Paulo e pela oportunidade de trabalhar em seu laboratório. Ao meu co-orientador Richard Garratt pela paciência e pelas discussões sobre estruturas protéicas. Ao meu amigo Lars Juhl Jensen (EMBL) pela ajuda na manipulação dos resultados e análises estatísticas. Aos meus amigos do Laboratório de Biologia Computacional. Ao programa de pós-graduação em Bioinformática e seus funcionários. À CAPES pela bolsa de doutorado. Em especial, à minha família, especialmente meu marido e filho que estiveram tão perto de mim durante essa tese, me dando todo o carinho e apoio necessários.

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The Function of the Nucleus in the Synthesis of Cytoplasmic Proteins

Cited by 30 publications

References 17 publications

Cell Changes During Protein Synthesis and Secretion: an Electron Microscopic Study of the Response of Lymphoid Tissue to Antigenic Stimulus

Cell Changes During Protein Synthesis and Secretion: an Electron Microscopic Study of the Response of Lymphoid Tissue to Antigenic Stimulus

Genetic regulation by non-coding RNAs

Bioinformática estrutural de proteínas modificadas por eventos de splicing alternativo

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