The function of SNHG7/miR‐449a/ACSL1 axis in thyroid cancer

Abstract

Thyroid cancer (TC) has been characterized as the most common malignant malady of the endocrine system. Small nucleolar RNA host gene 7 (SNHG7) has been reported to serve as a key regulator in a large number of human cancer types, but its role in TC and the underlying regulatory mechanism have never been evaluated yet. The present study indicated that the expression of SNHG7 was markedly higher in TC cell lines. Knockdown of SNHG7 led to a suppression of TC cell progression and migration. Acyl‐CoA synthetase long‐chain family member 1 (ACSL1) has also been demonstrated as an oncogene in many cancers. Herein an inhibition of ACSL1 after SNHG7 knockdown was captured. Further, the suppressing effects of SNHG7 knockdown on TC cell processes were counteracted by ACSL1 overexpression. Data from online bioinformatics analysis, RNA immunoprecipitation, and luciferase reporter assays validated the interaction between microRNA‐449a (miR‐449a) and SNHG7 or ACSL1. It was also verified that SNHG7 sequestered miR‐449a and therefore elevated ACSL1 expression levels. To conclude, the current study indicated that SNHG7 promoted proliferation and migration of TC cells by sponging miR‐449a and therefore upregulating ACSL1. The present study may provide more explorations about the molecular regulation mechanism of long noncoding RNAs in TC progression.

Prognostic Value of Long Noncoding RNA SNHG11 in Patients with Prostate Cancer

“…SNHGs have been verified and involved in the progression of several endocrine-related cancers such as thyroid cancer, breast cancer, pancreatic cancer, and prostate cancer [34][35][36][37]. RT-qPCR has revealed the higher expression of SNHG11 in prostate cancer tissues and cell lines than in BPH and normal cells.…”

Lipid Metabolism and Cancer

“…In thyroid cancer (TC), lncRNASNHG7 is oncogenic, and SNHG7 requires long-chain acyl coenzyme A synthase 1 (ACSL1) to promote TC progression. miR-449a can bind both SNHG7 and ACSL1, and SNHG7 can act as a sponge for miR-449a, thus increasing ACSL1 in TC cells, so the SNHG7/miR449a/ACSL1 axis contributes to the proliferation and migration of TC cells [ 150 ]. In addition, the target gene acyl coenzyme synthase 4 (ACSL4), another member of the ACSL family, is a downstream target of miR-34a-5p and miR-204-5p in prostate cancer.…”

Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer

“…To analyze the role of miR-499a in the regulation of ACSL1 by SNHG7, researchers conducted RIP and luciferase reporter gene analyses. The experiment concluded that SNHG7 can be used as a sponge for miR-449a, thereby increasing ACSL1 in TC cells and promoting the proliferation and migration of TC cells [130]. Additionally, lncRNA NEAT1 is highly expressed in docetaxel-resistant prostate cancer patients and cell lines.…”