The Function of Factor VII

Congenital Factor VII Deficiency. Haematological and Genetic Aspects

“…Successive generations were found to be affected in 5 out of 6 in stances where studies were carried out on members of the patient's family, but severe deficiency has never been described in more than one sibship of a family. All the 6 children of 2 severely affected patients (23,26) were discovered to have lesser degrees of factor V II deficiency, while consanguinity of the parents has been noted by A c kroyd (1). These findings are all consistent with inheritance of an abnormal gene having intermediate expression.…”

Development of Increased Factor Vii Activity During the Spontaneous Coagulation of Blood

“…Indeed, an increased activity did develop in a complete incubation mixture. However, these mixtures were found to be thromboplastin generation systems which function normally without Factor VII (17). Thus, this attempt failed in its pri- (Figure 2A).…”

Viscous Metamorphosis of Blood Platelets: A Study of the Relationship to Coagulation Factors and Fibrin Formation

“…Biggs, Douglas and Macfarlane (1953), in a study ofthe initial stages of blood coagulation, thought that at least five separate factors (antihaemophilic globuh (AHG), Christmas factor, Factors V and VII, and platelets), in the presence of calcium, were necessary for the generation of normal intrinsic thromboplastin. It is now considered that Factor VII does not take part in this reaction, but that it is only required for the action of tissue thromboplastin (Ackroyd, 1956). It was thought unlikely that all these factors reacted at once, and Bergsagel (195s) in an attempt to define the stages of throniboplastin generation considered that the initial stage of thromboplastin formation involved the interaction of AHG and Christmas factor in the presence of calcium.…”