The Function of COX-2 in Human Ovarian Carcinoma

Abstract

Also, the testicular teratoma 5 showing complete chondrosarcomatous differentiation is an interesting case although the histology shown in the manuscript does not clearly correspond to conventional chondrosarcoma but rather shows additionally undifferentiated mesenchyme. Again, a reinvestigation of the case with currently available tools would be worthwhile, which would allow identification and classification of chondrocyte differentiation. 6,7 Overall, clearly single (ie, very exceptional) cases may exist that represents extreme variants of neoplastic differentiation spectra. Whether this includes chondroma-identical pleomorphic adenoma and chondrosarcoma-identical chondroid chordoma requires further investigations. However, one should not forget, in practice, that these "extreme" cases are very rare-if they exist at all. Thus, particularly in cases in which the neoplastic counterparts (ie, chondrosarcoma for chondroid chordomas) are rather common, one should be very reluctant not to take these as a first diagnostic choice, even though this might, in a very exceptional case, be wrong.