The function of adipsin and C9 protein in the complement system in HIV-associated preeclampsia

David, Mikyle; Moodley, Jagidesa; Naicker, Thajasvarie

doi:10.1007/s00404-021-06069-9

Cited by 5 publications

(3 citation statements)

References 132 publications

(134 reference statements)

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“…FB was assessed by two studies, which determined a significant increase in serum levels ( 26 ) and not significant in plasma ( 28 ) of pregnant women with PE. Four studies consistently determined a greater concentration of adipsin/FD in serum ( 54 , 55 , 57 ) or plasma ( 56 ) of women with PE, particularly increased in SPE ( 54 ). Only one study by Blakey et al.…”

Section: Resultsmentioning

confidence: 98%

Systematic review of the complement components as potential biomarkers of pre-eclampsia: pitfalls and opportunities

Balduit,

Agostinis,

Mangogna

et al. 2024

Front. Immunol.

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The complement system (C) is a crucial component of the innate immune system. An increasing body of research has progressively shed light on the pivotal role of C in immunological tolerance at the feto-maternal interface. Excessive C activation or impaired C regulation may determine the onset of pregnancy-related pathological conditions, including pre-eclampsia (PE). Thus, several studies have investigated the presence of C components or split products in blood matrixes (i.e., plasma, serum), urine, and amniotic fluid in PE. In the current study, we systematically reviewed the currently available scientific literature reporting measurements of C components as circulating biomarkers in PE, based on a literature search using Pubmed, Scopus, and Embase databases. A total of 41 out of 456 studies were selected after full-text analysis. Fourteen studies (34.1%) were identified as measuring the blood concentrations of the classical pathway, 5 (12.1%) for the lectin pathway, 28 (68.3%) for the alternative pathway, 17 (41.5%) for the terminal pathway components, and 16 (39%) for C regulators. Retrieved results consistently reported C4, C3, and factor H reduction, and increased circulating levels of C4d, Bb, factor D, C3a, C5a, and C5b-9 in PE compared to normal pregnancies, depicting an overall scenario of excessive C activation and aberrant C regulation. With evidence of C activation and dysregulation, C-targeted therapy is an intriguing perspective in PE management. Moreover, we also discussed emerging pitfalls in C analysis, mainly due to a lack of experimental uniformity and biased cohort selection among different studies and laboratories, aiming to raise a more comprehensive awareness for future standardization.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024503070.

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Section: Resultsmentioning

confidence: 98%

Systematic review of the complement components as potential biomarkers of pre-eclampsia: pitfalls and opportunities

Balduit,

Agostinis,

Mangogna

et al. 2024

Front. Immunol.

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“…While some researchers reported no signi cant relationship between rst trimester lipids and PE [10] others reported signi cant difference in the major lipid fractions between those with normal pregnancies and those with PE [11], [12]. Despite the fact that a strong correlation between elevated adipsin and PE has been demonstrated in a recent study which also revealed the promising value of this protein as a diagnostic tool for PE [13] to date, no relationship between adipsin and PE has been reported among pregnant women in a Ghanaian community. We therefore explored the relationship between adipsin, lipids, coronary risk, socio-demographic factors and pre-eclampsia and evaluated the effectiveness and accuracy of these markers in the prediction of PE…”

Section: Introductionmentioning

confidence: 92%

Adipsin as a marker of preeclampsia in a Ghanaian community

Bawah,

Hussein,

Kuganab-Lem

et al. 2024

Preprint

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Background: This study was aimed at determining the levels of serum adipsin and lipids during the first trimester in pregnant women and to evaluate the relationship between these biochemical markers and preeclampsia (PE). Available data suggest that changes in the levels of adipsin is linked to the development of PE hence this study examined the potential of using this biomarker and adiposity in the prediction of the disease. Methods: This was a prospective case-control study which examined first trimester serum adipsin lipids and anthropometric parameters in pregnant women who later developed PE and those who did not. Urine protein and blood pressure were determined after 20th week of pregnancy and the values used to diagnose PE using the guidelines of the American Heart Association. Results: There were significant differences (p < 0.05) in the body mass index (BMI), coronary risk, lipids and adipsin between the PE group and the normotensive group. Analyses of risk factors for PE revealed that family history of hypertension, overweight, and history of cesarean operation are strong predictors of the disease. Conclusion: Our results suggest that adipsin may be involved in pregnancy related metabolic changes and these changes could be linked to the pathophysiology of PE.

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“…Several complement components are increased with HIV infection and PE, resulting in a hyper inflammatory state [ 28 ]. The shared pathogenic features of HIV infection and PE may result from an overly active complement [ 29 – 32 ]. Untreated HIV infection was found to have a protective effect against preeclampsia prior to the widespread implementation of antiretroviral therapy in a setting with a high prevalence of HIV and preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Differential expression of the angiotensin receptors (AT1, AT2, and AT4) in the placental bed of HIV-infected preeclamptic women of African ancestry

2023

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The Renin-Angiotensin-Aldosterone System (RAAS) is implicated in the pathophysiology of preeclampsia (PE). There is a paucity of data on uteroplacental angiotensin receptors AT1-2 and 4. We evaluated the immunoexpression of AT1R, AT2R, and AT4R within the placental bed of PE vs. normotensive (N) pregnancies stratified by HIV status. Placental bed (PB) biopsies (n = 180) were obtained from N and PE women. Both groups were stratified by HIV status and gestational age into early-and late onset-PE. Immuno-labeling of AT1R, AT2R, and AT4R was quantified using morphometric image analysis. Immunostaining of PB endothelial cells (EC) and smooth muscle cells of spiral arteries (VSMC) displayed an upregulation of AT1R expression compared to the N group (p < 0.0001). Downregulation of AT2R and AT4R expression was observed in PE vs. N group (p = 0.0042 and p < 0.0001), respectively. AT2R immunoexpression declined between HIV+ve and HIV−ve groups, while AT1R and AT4R displayed an increase. An increase in AT1R expression was noted in the EOPE−ve/+ve and LOPE−ve/+ve compared to N−ve/N+ve. In contrast, AT2R and AT4R expression decreased in EOPE−ve/+ve and LOPE-ve/+ve compared to N−ve/N+ve. We demonstrate a significant downregulation of AT2R and AT4R with a concomitant elevated AT1R immunoexpression within PB of HIV-infected PE women. In addition, a decline in AT2R and AT4R with an increase in AT1R immunoexpression in PE, EOPE, and LOPE vs. normotensive pregnancies, irrespective of HIV status. Thus highlighting differential immunoexpression of uteroplacental RAAS receptors based on pregnancy type, HIV status, and gestational age.

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The function of adipsin and C9 protein in the complement system in HIV-associated preeclampsia

Cited by 5 publications

References 132 publications

Systematic review of the complement components as potential biomarkers of pre-eclampsia: pitfalls and opportunities

Systematic review of the complement components as potential biomarkers of pre-eclampsia: pitfalls and opportunities

Adipsin as a marker of preeclampsia in a Ghanaian community

Differential expression of the angiotensin receptors (AT1, AT2, and AT4) in the placental bed of HIV-infected preeclamptic women of African ancestry

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