The Frontotemporal Dementia Syndromes

Mendez, Mario F.

doi:10.1002/9780470669600.ch57

Cited by 3 publications

(4 citation statements)

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“…The MATS was developed by FK, CK, and JRH. First, the literature was screened for any case studies or retrospective studies that reported criminal risk behaviours in dementia (e.g., Kim et al., 2 Liljegren et al., 8 Diehl‐Schmid et al., 9 and Mendez 17 ). Reported behaviours were compiled and additional criminal risk behaviours reported in our clinic were added to the list.…”

Section: Methodsmentioning

confidence: 99%

Examining the propensity and nature of criminal risk behaviours in frontotemporal dementia syndromes and Alzheimer's disease

Kumfor,

Wei,

Ries

et al. 2024

Alz & Dem Diag Ass & Dis Mo

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INTRODUCTIONSome people with dementia develop changes in behaviour and cognition that may lead to interactions with police or the legal system. However, large, prospective case–control studies examining these behaviours are lacking.METHODSOne hundred and forty‐four people with dementia and 53 controls completed the Misdemeanours and Transgressions Screener.RESULTSCriminal risk behaviours were reported in: 65.6% of behavioural‐variant frontotemporal dementia, 46.2% of right‐lateralised semantic dementia, and 27.0% of Alzheimer's disease patients. In 19.1% of patients these behaviours led to contact with police or authority figures. Compared to controls, people with dementia showed higher rates of physical assault (p = 0.024), financial/professional recklessness (p = 0.009), and inappropriate behaviours (p = 0.052).DISCUSSIONCriminal risk behaviours are common across dementia subtypes and may be one of the first clinical signs of frontotemporal dementia. Further research to understand how to balance risk minimisation with an individual's liberties as well as the inappropriate criminalisation of people with dementia is needed.Highlights The Misdemeanours and Transgressions Screener is a new tool to assess criminal risk behaviours. Forty‐seven percent of patients with dementia show criminal risk behaviour after dementia onset. Behaviours included verbal abuse, traffic violations, physical assault. New onset of criminal risk behaviours >50 years is a clinical sign for frontotemporal dementia.

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Section: Methodsmentioning

confidence: 99%

Examining the propensity and nature of criminal risk behaviours in frontotemporal dementia syndromes and Alzheimer's disease

Kumfor,

Wei,

Ries

et al. 2024

Alz & Dem Diag Ass & Dis Mo

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“…The VMPFC and its connections are central to deficits in morality in individuals with bvFTD (Schroeter et al, 2015). In addition to pathologic involvement of the VMPFC with altered moral feelings, bvFTD pathology extends to right anterior temporal impairment of emotional empathy and socioemotional semantics and to OFC changes with disinhibited behavior (Mendez, 2006(Mendez, , 2010Younes et al, 2022).…”

Section: Frontotemporal Dementiamentioning

confidence: 99%

The Implications of Moral Neuroscience for Brain Disease: Review and Update

Mendez

2023

Cognitive and Behavioral Neurology

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The last 2 decades have seen an explosion of neuroscience research on morality, with significant implications for brain disease. Many studies have proposed a neuromorality based on intuitive sentiments or emotions aimed at maintaining collaborative social groups. These moral emotions are normative, deontological, and action based, with a rapid evaluation of intentionality. The neuromoral circuitry interacts with the basic mechanisms of socioemotional cognition, including social perception, behavioral control, theory of mind, and social emotions such as empathy. Moral transgressions may result from primary disorders of moral intuitions, or they may be secondary moral impairments from disturbances in these other socioemotional cognitive mechanisms. The proposed neuromoral system for moral intuitions has its major hub in the ventromedial prefrontal cortex and engages other frontal regions as well as the anterior insulae, anterior temporal lobe structures, and right temporoparietal junction and adjacent posterior superior temporal sulcus. Brain diseases that affect these regions, such as behavioral variant frontotemporal dementia, may result in primary disturbances of moral behavior, including criminal behavior. Individuals with focal brain tumors and other lesions in the right temporal and medial frontal regions have committed moral violations. These transgressions can have social and legal consequences for the individuals and require increased awareness of neuromoral disturbances among such individuals with brain diseases.

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“…1,2 Criminal behavior ranges from violence to sexual advances, theft, and traffic violations. [3][4][5][6][7] Socially inappropriate behavior may manifest as impulsive and disinhibited action, including open talk about private matters, rude comments to others, and maladaptive emotional reactions. 8 In general, neurobiological explanations for criminal and socially inappropriate behavior use a range of models, from structural to neurochemical.…”

Section: Introductionmentioning

confidence: 99%

“…Previous research has shown that criminal behavior and socially inappropriate behavior are encountered among patients with dementia; in fact, they are sometimes the first sign of a dementing disorder . Criminal behavior ranges from violence to sexual advances, theft, and traffic violations . Socially inappropriate behavior may manifest as impulsive and disinhibited action, including open talk about private matters, rude comments to others, and maladaptive emotional reactions .…”

Section: Introductionmentioning

confidence: 99%