The frontline of alternatives to animal testing: novel in vitro skin model application in drug development and evaluation
He Zhao,
Zhaozeng Chen,
Xingchen Kang
et al.
Abstract:The FDA Modernization Act 2.0 has brought nonclinical drug evaluation into a new era. In vitro models are widely used and play an important role in modern drug development and evaluation, including early candidate drug screening and preclinical drug efficacy and toxicity assessment. Driven by regulatory steering and facilitated by well-defined physiology, novel in vitro skin models are emerging rapidly, becoming the most advanced area in alternative testing research. The revolutionary technologies bring us man… Show more
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