The frontal lobes and the regulation of mental activity

Thompson-Schill, Sharon L.; Bedny, Marina; Goldberg, Robert F.

doi:10.1016/j.conb.2005.03.006

Cited by 290 publications

(221 citation statements)

References 71 publications

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“…This observation is consistent with findings in the literature (see reviews by [Bunge, 2004;Duncan and Owen, 2000;Owen, 2000]) and with the view that the VLPFC subserves rather general control functions that may be needed in quite different task contexts [Bunge, 2004;Duncan and Owen, 2000;Petrides, 1994;Thompson-Schill et al, 2005].…”

Section: Mid-vlpfc Activitysupporting

confidence: 92%

The engagement of mid‐ventrolateral prefrontal cortex and posterior brain regions in intentional cognitive activity

Dove¹,

Manly²,

Epstein³

et al. 2007

Human Brain Mapping

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It is now widely recognized that cognitive processes are carried out by a distributed network of brain areas, some of which are involved in perceptual processing of a stimulus, whilst others are involved in cognitive control processes required to carry out certain tasks. In this study, differential contributions of higher visual areas and of an area involved in cognitive control processes were investigated in a task requiring participants to simply look at a stimulus or to look with the intention of remembering. Varying the extent to which intentional cognitive processes were required and the stimulus material in this task allowed the analysis of ''top-down'' and ''bottom-up'' influences on these areas, respectively. Significant increases in the mid-ventrolateral prefrontal cortex (mid-VLPFC) were only observed when the stimuli were viewed with an intention in mind, irrespective of the stimulus type. In contrast, activity in the parahippocampal place area and the fusiform face area, was only modulated in conditions requiring intentional control when stimuli were presented that also elicited activity in these regions during passive viewing. These findings help to clarify the complimentary role that the mid-VLPFC and posterior higher visual areas play in controlled and relatively automatic memory process-

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Section: Mid-vlpfc Activitysupporting

confidence: 92%

The engagement of mid‐ventrolateral prefrontal cortex and posterior brain regions in intentional cognitive activity

Dove¹,

Manly²,

Epstein³

et al. 2007

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…First, one might try to classify all seemingly distinct tasks that activate this region under one common denominator. Thompson-Schill and colleagues, for instance, suggest that the inferior frontal cortex is involved in 'the regulation of mental activity ' (Thompson-Schill, Bedny, & Goldberg, 2005). Hierarchical processing is another suggested overarching function of the inferior frontal cortex (Koechlin & Jubault, 2006;Tettamanti & Weniger, 2006;see Friederici, 2006;van Schie, Toni, & Bekkering, 2006 for related accounts).…”

Section: Discussionmentioning

confidence: 99%

Neural evidence for the interplay between language, gesture, and action: A review

2007

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Co-speech gestures embody a form of manual action that is tightly coupled to the language system. As such, the co-occurrence of speech and co-speech gestures is an excellent example of the interplay between language and action. There are, however, other ways in which language and action can be thought of as closely related. In this paper we will give an overview of studies in cognitive neuroscience that examine the neural underpinnings of links between language and action. Topics include neurocognitive studies of motor representations of speech sounds, action-related language, sign language and co-speech gestures. It will be concluded that there is strong evidence on the interaction between speech and gestures in the brain. This interaction however shares general properties with other domains in which there is interplay between language and action.

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“…Prior work has also shown that TMS to the LPFC and TMS to left occipital areas cause similar impairments during verb generation (in sighted and early blind groups, respectively) (28). Therefore, like the LPFC, occipital areas may support selection and manipulation of linguistic representations in working memory (47,48). Alternatively, the left occipital cortex might combine linguistic units into structured wholes (49) or support recursive structure building during sentence processing (12,33,50).…”

Section: Discussionmentioning

confidence: 99%

Language processing in the occipital cortex of congenitally blind adults

Bedny

Pascual‐Leone

Dodell-Feder

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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361

392

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Humans are thought to have evolved brain regions in the left frontal and temporal cortex that are uniquely capable of language processing. However, congenitally blind individuals also activate the visual cortex in some verbal tasks. We provide evidence that this visual cortex activity in fact reflects language processing. We find that in congenitally blind individuals, the left visual cortex behaves similarly to classic language regions: (i) BOLD signal is higher during sentence comprehension than during linguistically degraded control conditions that are more difficult; (ii) BOLD signal is modulated by phonological information, lexical semantic information, and sentence-level combinatorial structure; and (iii) functional connectivity with language regions in the left prefrontal cortex and thalamus are increased relative to sighted individuals. We conclude that brain regions that are thought to have evolved for vision can take on language processing as a result of early experience. Innate microcircuit properties are not necessary for a brain region to become involved in language processing.plasticity | language evolution

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The frontal lobes and the regulation of mental activity

Cited by 290 publications

References 71 publications

The engagement of mid‐ventrolateral prefrontal cortex and posterior brain regions in intentional cognitive activity

The engagement of mid‐ventrolateral prefrontal cortex and posterior brain regions in intentional cognitive activity

Neural evidence for the interplay between language, gesture, and action: A review

Language processing in the occipital cortex of congenitally blind adults

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