The Frontal Behavioral Inventory in the differential diagnosis 
of frontotemporal dementia

Kertesz, Andrew; Nadkarni, Neelesh K.; Davidson, Wilda; Thomas, Alex

doi:10.1017/s1355617700644041

Cited by 277 publications

(214 citation statements)

References 29 publications

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“…[21][22][23][24][25][26] Measures of executive function and behavioral impairment include the ALS-CBS 27 and the ALS-Frontal Behavioral Inventory (FBI). 28 The cognitive tests were selected to assess executive function and select language skills because the ALS variant of dementia is known to be of the frontotemporal lobar dementia subtype. The consensus criteria of Strong 29 was used to classify impairment as absent, mild, or moderate.…”

Section: Methods Research Questionsmentioning

confidence: 99%

Cognitive impairment, behavioral impairment, depression, and wish to die in an ALS cohort

et al. 2016

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Objective: To evaluate relationships among cognitive, behavioral, and psychiatric/psychosocial measures assessed in a multicenter cohort of patients with amyotrophic lateral sclerosis (ALS). Methods:Recently diagnosed patients with definite or probable ALS diagnosis were administered 7 standardized psychiatric/psychosocial measures, including the Patient Health Questionnaire for diagnosis of depression and elicitation of wish to die. The Cognitive Behavioral Screen was used to classify both cognitive and behavioral impairment (emotional-interpersonal function). An ALS version of the Frontal Behavioral Inventory and Mini-Mental State Examination were also administered.Results: Of 247 patients included, 79 patients (32%) had neither cognitive nor behavioral impairment, 100 (40%) had cognitive impairment, 23 (9%) had behavioral impairment, and 45 (18%) had comorbid cognitive and behavioral decline. Cognitive impairment, when present, was in the mild range for 90% and severe for 10%. Thirty-one patients (12%) had a major or minor depressive disorder (DSM-IV criteria). Cognitive impairment was unrelated to all psychiatric/psychosocial measures. In contrast, patients with behavioral impairment reported more depressive symptoms, greater hopelessness, negative mood, and more negative feedback from spouse or caregiver. A wish to die was unrelated to either cognitive or behavioral impairment.Conclusions: While we found no association between cognitive impairment and depression or any measure of distress, behavioral impairment was strongly associated with depressive symptoms and diagnoses although seldom addressed by clinicians. Thoughts about ending life were unrelated to either cognitive or behavioral changes, a finding useful to consider in the context of policy debate about physician-assisted death.

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Section: Methods Research Questionsmentioning

confidence: 99%

Cognitive impairment, behavioral impairment, depression, and wish to die in an ALS cohort

et al. 2016

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“…Kertesz et al, 2000). Some of these scales contain several questions related to various deficits (e.g., apathy, inhibition) together with questions enquiring about the patients' insight into their language deficit (e.g.…”

Section: Methods To Assess Anosognosia For Language Disordersmentioning

confidence: 99%

Assessing anosognosia: a critical review

Cocchini

Beschin²,

Sala

2012

Acta Neuropsychol

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“…Depressive symptoms such as irritability seem to remain present for longer periods (Kertesz et al 2000).…”

Section: Behavior Emotion and Moodmentioning

confidence: 99%

A review on primary progressive aphasia

Léger

Johnson²

2008

NDT

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Primary progressive aphasia (PPA) is a neurodegenerative disease of insidious onset presenting with progressive isolated loss of language function, without signifi cant impairment in other cognitive domains. Current diagnostic criteria require the language dysfunction to remain isolated for at least two years, and to remain the salient feature as the disease progresses, usually to involve other domains such as behavior, executive functions, and judgment. Although PPA in its early stages can usually be differentiated from probable Alzheimer's disease (PRAD) and the behavioral variant of frontotemporal lobar degeneration by the absence of signifi cant changes in memory and behavior, and the preservation of activities daily living, progression of the disease often leads to defi cits more consistent with the latter. Underlying etiologies remain heterogeneous: the neuropathological characteristics associated with frontotemporal lobar degeneration, cortocobasal degeneration, and motor neuron disease are usually found. There is a strong genetic susceptibility with affl iction of fi rst-degree relatives with similar disease in up to 40 to 50% in some series. Pathogenic mutations in genes coding for the proteins tau and progranulin have been isolated. These are leading to a better understanding of the neuropathological mechanisms and hopefully targeted disease-modifying therapy. Current therapy is limited to improving mood symptoms and targeting behavior changes as they develop. Referral to specialized centers where speech therapy, counseling, and education for both patient and caregiver are available may be helpful.

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The Frontal Behavioral Inventory in the differential diagnosis of frontotemporal dementia

Cited by 277 publications

References 29 publications

Cognitive impairment, behavioral impairment, depression, and wish to die in an ALS cohort

Cognitive impairment, behavioral impairment, depression, and wish to die in an ALS cohort

Assessing anosognosia: a critical review

A review on primary progressive aphasia

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