The Frontal Assessment Battery (FAB): normative values in an Italian population sample

Appollonio, Ildebrando; Leone, María Eugenia; Isella, Valeria; Piamarta, F.; Consoli, T.; Villa, M. L.; Forapani, E.; Russo, Alessandro; Nichelli, Paolo Frigio

doi:10.1007/s10072-005-0443-4

Cited by 546 publications

(396 citation statements)

References 27 publications

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“…The profile score has predefined cutoff levels to grade the memory performance as normal (22)(23)(24) mild (17)(18)(19)(20)(21), moderate (10-16), or severe (0-9) impairment. 19 The Frontal Assessment Battery 20 is a screening battery for executive impairments.…”

Section: Outcome Assessmentmentioning

confidence: 99%

Cognitive Function in Survivors of Out-of-Hospital Cardiac Arrest After Target Temperature Management at 33°C Versus 36°C

et al. 2015

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Background— Target temperature management is recommended as a neuroprotective strategy after out-of-hospital cardiac arrest. Potential effects of different target temperatures on cognitive impairment commonly described in survivors have not been investigated sufficiently. The primary aim of this study was to evaluate whether a target temperature of 33°C compared with 36°C was favorable for cognitive function; the secondary aim was to describe cognitive impairment in cardiac arrest survivors in general. Methods and Results— Study sites included 652 cardiac arrest survivors originally randomized and stratified for site to temperature control at 33°C or 36°C within the Target Temperature Management trial. Survival until 180 days after the arrest was 52% (33°C, n=178/328; 36°C, n=164/324). Survivors were invited to a face-to-face follow-up, and 287 cardiac arrest survivors (33°C, n=148/36°C, n=139) were assessed with tests for memory (Rivermead Behavioural Memory Test), executive functions (Frontal Assessment Battery), and attention/mental speed (Symbol Digit Modalities Test). A control group of 119 matched patients hospitalized for acute ST-segment–elevation myocardial infarction without cardiac arrest performed the same assessments. Half of the cardiac arrest survivors had cognitive impairment, which was mostly mild. Cognitive outcome did not differ ( P >0.30) between the 2 temperature groups (33°C/36°C). Compared with control subjects with ST-segment–elevation myocardial infarction, attention/mental speed was more affected among cardiac arrest patients, but results for memory and executive functioning were similar. Conclusions— Cognitive function was comparable in survivors of out-of-hospital cardiac arrest when a temperature of 33°C and 36°C was targeted. Cognitive impairment detected in cardiac arrest survivors was also common in matched control subjects with ST-segment–elevation myocardial infarction not having had a cardiac arrest. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT01946932.

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Section: Outcome Assessmentmentioning

confidence: 99%

Cognitive Function in Survivors of Out-of-Hospital Cardiac Arrest After Target Temperature Management at 33°C Versus 36°C

et al. 2015

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“…Hand-dominance was assessed by a questionnaire (Oldfield, 1971). Abstract reasoning was assessed by 'Similarities' tasks (Italian version: Appollonio et al, 2005;British version: Wechsler, 1997; sub-test of Wechsler Adult Intelligent Scale, WAIS-III; statistical comparisons for each target group were performed only with regards to the HP group patients tested with each version). Extrapersonal neglect was assessed by the line cancellation, star cancellation, figure and shape copying subtest of the Behavioural Inattention Test ( (Wilson, Cockburn, & Halligan, 1987).…”

Section: Neurological and Neuropsychological Assessmentmentioning

confidence: 99%

Motor versus body awareness: Voxel-based lesion analysis in anosognosia for hemiplegia and somatoparaphrenia following right hemisphere stroke

Moro

Pernigo

Tsakiris

et al. 2016

Cortex

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Anosognosia for hemiplegia (AHP) is informative about the neurocognitive basis of motor awareness. However, it is frequently associated with concomitant symptoms, such as hemispatial neglect and disturbances in the sense of body ownership (DSO). Although double dissociations between these symptoms have been reported, there is ongoing debate about whether they are manifestations of independent abnormalities, or a single neurocognitive deficit.We aimed to investigate the specificity of lesions associated with AHP by surpassing four, existing methodological limitations: (a) recruit a relatively large sample of patients (total N = 70) in a multi-centre study; (b) identify lesions associated with AHP in grey and white matter using voxel-based methods; (c) take into account the duration of AHP and concomitant neglect symptoms; and (d) compare lesions against a control hemiplegic group , patients suffering from AHP and DSO, and a few, rare patients with selective DSO. Results indicated that acute AHP is associated with a wide network, mainly including: (1) the Rolandic operculum, (2) the insula and (3) the superior temporal gyri. Subcortically, damage mainly involved the basal ganglia and white matter, mostly the superior corona radiate, arcuate fasciculus and the ventral part of the superior longitudinal fasciculus. Persistent symptoms were linked with wider damage involving fronto-temporal cortex and long white matter tracts. A shift in the latero-medial direction (mainly involving the basal ganglia and surrounding white matter) emerged when DSO was taken accounted for. These results suggest that while bodily awareness is processed by areas widely distributed across the brain, intact subcortical structures and white matter tracts may be necessary to support basic feelings of owning and controlling contralateral body parts. An accurate and 'up-to-date' awareness of our motor abilities, however, may rely also on intact processing in cortical areas which presumably allow higher-order inferences about the current state of the body. Reviewer #1: The authors investigated the neuronal basis for anosognosia (AHP) and related disorders (body awareness and spatial neglect). The authors report a 70-strong study cohort, which they separate into different groups for their analysis and claim a different neuronal pattern for the acute and chronic stages of anosognosia. Whilst this study is well-written and strong neuropsychologically, the imaging analysis and in particular its interpretation lack substance. The anatomical regions described most the time do not match with the figures provided and therefore the conclusion of the current manuscript are not supported by the neuroimaging findings. The authors need to work on this aspect before publication should be considered. Motor Versus Body General comments1. The introduction is very well written and leads nicely to the research hypotheses. However, given the limited publications available on the neuronal basis of anosognosia the authors should make an effort to include a ...

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“…Specifically, she obtained a score at the inferior limits of normality in short-term numerical and verbal memory, but the visuospatial ability to repeat sequences was normal (Table 1). [8][9][10][11][12][13][14][15][16] The long-term verbal memory was considered normal in the tests with textured material as the brief story presented and in delayed recall of material not related, while the immediate re-enactment could be considered at the lower limits of normality.…”

Section: Case Reportsmentioning

confidence: 99%

Musical hallucinations in elderly patients with visuospatial impairment: two case reports

et al. 2017

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Musical hallucinations are an uncommon type of auditory hallucinations, they widely occur in elderly. Our group analyzed medical history, pharmacological therapy, neuropsychological pattern, audiometric testing, electroencephalogram, cerebral magnetic resonance and cerebral fludeoxyglucose-positron emission tomography (FDG-PET) of two patients. FDG-PET showed in both patients hypometabolism pronounced in posterior regions. In particular the medial-inferior temporal cortex and the occipital associative areas were affected. Moreover, neuropsychological pattern suggested a visuospatial-executive deficit, conformed to the occipital involvement. Our reported cases might suggest that musical hallucinations have been arisen from a combination of peripheral and central dysfunction. A further explanation might be that musical hallucinations result from multiple white matter lacunar lesions due to small vascular events. A question is whether musical hallucinations might be primarily associated with occipital areas hypometabolism and visuospatial alterations typically associated with Levy body dementia (LBD).

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The Frontal Assessment Battery (FAB): normative values in an Italian population sample

Cited by 546 publications

References 27 publications

Cognitive Function in Survivors of Out-of-Hospital Cardiac Arrest After Target Temperature Management at 33°C Versus 36°C

Cognitive Function in Survivors of Out-of-Hospital Cardiac Arrest After Target Temperature Management at 33°C Versus 36°C

Motor versus body awareness: Voxel-based lesion analysis in anosognosia for hemiplegia and somatoparaphrenia following right hemisphere stroke

Musical hallucinations in elderly patients with visuospatial impairment: two case reports

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