“…CP is to a major extent eliminated through previous report on ifosfamide [19], being shorter compared with the turn-over of CYP3A4 [29,37], is likely 4-hydroxylation by CYP2B6, CYP2C9 and CYP3A4 [2, to be due to CP inducing an isoenzyme other than inhibit CP metabolism in human liver microsomes [47]. It is reasonable to believe that coadministration of fluconazole CYP3A4 or multiple enzymes.…”