The frequency of sicca symptoms and <scp>S</scp>jögren's syndrome in patients with systemic sclerosis

Kobak, Şenol; Öksel, Fahrettin; Aksu, Kenan; Kabasakal, Yasemin

doi:10.1111/j.1756-185x.2012.01810.x

Cited by 48 publications

(54 citation statements)

References 12 publications

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“…In the setting of salivary gland dysfunction, there is a decrease in salivary nitrate concentration and corollary increase in urinary excretion, thereby reducing total body nitrate content and its enterosalivary circulation[84,193,231,293]. Significantly, several diseases that share both disproportionately high rates of vascular disease and PH, including Sjögren's and systemic sclerosis[294–297], HIV[7,11], and cystic fibrosis[298] also feature dysregulated salivary flow[299–302] and altered oral microbial populations[224,303–306]. While there is no conclusive link between these factors, these associations offer a potentially novel line of investigation.…”

Section: Dysbiosis Of the Microbiome In Pulmonary Hypertension And Vascmentioning

confidence: 99%

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

Koch

Gladwin

Freeman

et al. 2017

Free Radical Biology and Medicine

141

127

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Recent insights into the bioactivation and signaling actions of inorganic, dietary nitrate and nitrite now suggest a critical role for the microbiome in the development of cardiac and pulmonary vascular diseases. Once thought to be the inert, end-products of endothelial-derived nitric oxide (NO) heme-oxidation, nitrate and nitrite are now considered major sources of exogenous NO that exhibit enhanced vasoactive signaling activity under conditions of hypoxia and stress. The bioavailability of nitrate and nitrite depend on the enzymatic reduction of nitrate to nitrite by a unique set of bacterial nitrate reductase enzymes possessed by specific bacterial populations in the mammalian mouth and gut. The pathogenesis of pulmonary hypertension (PH), obesity, hypertension and CVD are linked to defects in NO signaling, suggesting a role for commensal oral bacteria to shape the development of PH through the formation of nitrite, NO and other bioactive nitrogen oxides. Oral supplementation with inorganic nitrate or nitrate-containing foods exert pleiotropic, beneficial vascular effects in the setting of inflammation, endothelial dysfunction, ischemia-reperfusion injury and in pre-clinical models of PH, while traditional high-nitrate dietary patterns are associated with beneficial outcomes in hypertension, obesity and CVD. These observations highlight the potential of the microbiome in the development of novel nitrate- and nitrite-based therapeutics for PH, CVD and their risk factors.

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Section: Dysbiosis Of the Microbiome In Pulmonary Hypertension And Vascmentioning

confidence: 99%

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

Koch

Gladwin

Freeman

et al. 2017

Free Radical Biology and Medicine

141

127

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“…In SSc, xerostomia is not only a subjective sensation, but it is usually the consequence of an objective reduction in the quantity of the saliva produced. SSc patient's salivary flow was assessed in different studies (Andonopoulos et al , ; Nagy et al , ; Chu et al , ; Kobak et al , ; Baron et al , ,b). The largest cohort study (163 SSc patients vs 231 controls), performed recently by the Canadian Scleroderma Research Group, revealed that the disease was associated with a lesser saliva production (63.19 mg min −1 vs 147.52 mg min −1 ) (Baron et al , ).…”

Section: Orofacial Manifestationsmentioning

confidence: 99%

The spectrum of orofacial manifestations in systemic sclerosis: a challenging management

et al. 2016

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Systemic sclerosis (SSc) is a rare multisystem connective tissue disorder characterized by the triad fibrosis, vasculopathy and immune dysregulation. This chronic disease has a significant impact on the orofacial region that is involved in more than two-thirds of the cases. SSc patients can show a wide array of oral manifestations, which are usually associated with a severe impairment of the quality of life. They often present a decreased the salivary flow and a reduced mouth opening that contribute substantially to the worsening of the oral health status. Therefore, SSc patients require specific and multidisciplinary interventions that should be initiated as early as possible. The identification of specific radiological and clinical signs at the early stage will improve the management of such patients. This study reviews the wide spectrum of orofacial manifestations associated with SSc and suggests clues for the oral management that remains challenging.

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“…A classic triad of symptoms predominates in the clinical manifestation of Sjögren's syndrome; aside from xerostomia, it also includes dry eye syndrome/keratoconjuntivitis sicca and polyarthritis [18]. The presence of proteins against glandular duct cells, anti-RO/SSA and antiLa/SSB antibodies and rheumatoid factor leads to the destruction of secretory vesicles with associated lymphocytic infiltration [19].…”

mentioning

confidence: 99%

Xerostomia of Various Etiologies: A Review of the Literature

Tanasiewicz¹,

Hildebrandt²,

Obersztyn³

2016

Adv Clin Exp Med

169

122

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The frequency of sicca symptoms and Sjögren's syndrome in patients with systemic sclerosis

Abstract: In the present study, highly frequent sicca symptoms and Sjögren's syndrome based on AECG criteria were noted in patients with systemic sclerosis. The SSc-SS patient group had less severe clinical course and lung involvement.

Cited by 48 publications

References 12 publications

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

The spectrum of orofacial manifestations in systemic sclerosis: a challenging management

Xerostomia of Various Etiologies: A Review of the Literature

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