The Frequency of Post-infectious IBS (PI-IBS) in Patients with Acute Diarrhea and the Risk Factors for PI-IBS of Special Reference to the Colonoscopic Findings

Lee, Jong-Soo; Jung, Sung-Ae; Shim, Ki–Nam; Kim, Seong‐Eun; Yeom, Moon Sun; Lee, Han Hyo; Nam, Jun Sik; Jung, Hye-Kyung; Yi, Sun Young; Kim, Doe-Young; Yoo, Kwon; Moon, Il Hwan

doi:10.1016/s0016-5107(04)01266-0

Cited by 4 publications

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“…Almost half of patients with MAS have been shown to have SIBO, 13 which might be related to small intestinal stasis in association with large quantity of nutrient-rich fluid in the lumen. In fact, there could be etiologic and pathophysiologic overlap between MAS and D-IBS as evidenced by the fact that patients with PI-IBS, who have organic basis more frequently, are more often diarrhea-predominant like post-infective malabsorption syndrome, 15 , 16 and have abnormal small intestinal permeability, 17 Also, patients with D-IBS may have SIBO 18 and lactose malabsorption 18 more frequently. These findings may suggest that patients with chronic diarrhea, even if non-specific and D-IBS should be investigated for SIBO.…”

Section: Discussionmentioning

confidence: 99%

“…14 In fact, there may be some pathophysiological and etiological overlap between D-IBS and mild malabsorption syndrome. This is evidenced by the fact that patients with post-infectious IBS (PI-IBS), who have organic basis more frequently, are more often diarrhea-predominant, 15 , 16 and have abnormal small intestinal permeability. 17 Also, patients with D-IBS may have SIBO 18 and lactose malabsorption 18 more frequently.…”

Section: Introductionmentioning

confidence: 99%

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Frequency of Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome and Chronic Non-Specific Diarrhea

Ghoshal¹,

Kumar²,

Mehrotra³

et al. 2010

J Neurogastroenterol Motil

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IntroductionSmall intestinal bacterial overgrowth (SIBO) occurs in varying frequency in irritable bowel syndrome (IBS). We studied the frequency of SIBO in IBS and chronic non-specific diarrhea (CNSD).Methods129 patients with IBS (Manning's criteria), 73 with CNSD (≥ 4 weeks diarrhea with two of these tests normal [urine D-xylose, fecal fat and duodenal biopsy]) and 51 healthy controls (HC) were evaluated for SIBO using glucose hydrogen breath test (GHBT). Diarrhea-predominant IBS (D-IBS) was grouped into CNSD. Rise in breath hydrogen 12 ppm above basal following 100 g glucose was diagnostic of SIBO.ResultsOf 129 patients with IBS, 7 were constipation (C-IBS), and 122 were of indeterminate type (I-IBS). Patients with IBS were younger than HC and CNSD (IBS vs. HC: 36.6 yr ± 11.4 vs. 44.1 yr ± 13.6, p = 0.001; IBS vs. CNSD: 36.6 yr ± 11.4 vs. 42 yr ± 14.5, p = 0.003). Patients with CNSD were comparable to HC in age (42 yr ± 14.5 vs. 44.1 yr ± 13.6, p = ns). Patients with IBS were more often male than HC [108/129 (83.7%) vs. 34/51 (66.7%) p = 0.02]; gender of CNSD and HC was comparable [male 39/73 (53.4%) vs. 34/51 (66.7%) p = ns]. SIBO was commoner in CNSD than HC [16 (21.9%) vs. 1 (2%), p = 0.003], but was comparable in IBS and HC [11 (8.5%) vs. 1 (2%), p = 0.18]. Patients with CNSD more often had SIBO than IBS [16 (21.9%) vs. 11 (8.5%), p = 0.007].ConclusionsSIBO was more common in CNSD including D-IBS than other types of IBS and HC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%