The Frequency of Obstructive Sleep Apnea in Patients with Non-cystic Fibrosis Bronchiectasis

Börekçi, Şermin; Sekibağ, Yonca; Harbiyeli, Deniz Öngel; Müsellim, Benan

doi:10.5152/turkthoracj.2021.20194

Cited by 4 publications

(10 citation statements)

References 22 publications

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“…It has been shown that patients with bronchiectasis have multiple risk factors for SDB, such as chronic inflammation and ventilatory impairment due to obstructive and/or restrictive patterns and chronic secretions, caused by impaired muco-ciliary clearance and by excessive production of mucous plugs [ 56 , 57 ]. Only a few studies have thoroughly investigated the prevalence of SDB, particularly OSA, in patients with bronchiectasis [ 10 , 11 ]. Two studies conducted in Brazil and Turkey reported the results of polysomnography (PSG) in 49 and 43 patients with bronchiectasis, respectively.…”

Section: Sleep-disordered Breathing and Bronchiectasismentioning

confidence: 99%

“…Prevalence of OSA ranged between 41% and 56% and, in more than half cases in both studies, it was of mild severity (apnea-hypopnea index (AHI) 5–15). Risk factors for the presence of OSA were older age, male gender, larger neck circumference and P. aeruginosa colonization [ 10 , 11 ]. Contrary to what was expected, body mass index (BMI), pulmonary functional parameters and the number of prior exacerbations did not differ between patients with or without OSA.…”

Section: Sleep-disordered Breathing and Bronchiectasismentioning

confidence: 99%

“…Smoking history was not evaluated in these studies, probably because pathophysiological mechanisms for OSA in patients with bronchiectasis may at least in part be different from those of the general population. Recognized markers of bronchiectasis severity, such as the number of exacerbations per year ≥ 3, were associated with longer snoring periods, worse oxygen saturation (SpO 2 ) nadir and higher total sleep time with SpO 2 < 90% [ 10 ]. To our knowledge, literature is lacking regarding the impact of treating SDB in these patients and whether airway-clearance techniques and pulmonary rehabilitation may have a positive effect on OSA.…”

Section: Sleep-disordered Breathing and Bronchiectasismentioning

confidence: 99%

“…In the study by Faria Junior et al, daytime levels of sleepiness evaluated using the Epworth sleepiness scale (ESS) did not differ between patients with and without OSA [ 11 ]. Similarly, comparing subjects with bronchiectasis with and without OSA, Borekci et al, did not observe any difference regarding excessive daytime sleepiness and snoring [ 10 ]. These findings suggest that patients with bronchiectasis may require screening for OSA regardless of typical risk factors and symptoms.…”

Section: Sleep-disordered Breathing and Bronchiectasismentioning

confidence: 99%

See 3 more Smart Citations

Sleep-Disordered Breathing and Chronic Respiratory Infections: A Narrative Review in Adult and Pediatric Population

Faverio

Zanini

Monzani

et al. 2023

IJMS

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Sleep-disordered breathing (SDB) comprises different diseases characterized by abnormal respiratory patterns during sleep including obstructive sleep apnea. SDB prevalence and impact in patients with chronic respiratory infections have been only marginally studied. The purpose of this narrative review is to report the prevalence and impact of SDB in chronic respiratory infections, including cystic fibrosis (CF), bronchiectasis and mycobacterial infections, and explore the possible pathophysiological mechanisms. Common pathophysiological mechanisms, underlying SDB onset in all chronic respiratory infections, include inflammation, which plays a central role, chronic nocturnal cough and pain, excessive production of mucous plugs, presence of obstructive and/or restrictive ventilatory impairment, upper airways involvement, and comorbidities, such as alteration of nutritional status. SDB may affect about 50% of patients with bronchiectasis. The severity of the disease, e.g., patients colonized with P. aeruginosa and frequent exacerbators, as well as comorbidities, such as chronic obstructive pulmonary disease and primary ciliary dyskinesia, may impact SDB onset. SDB may also frequently complicate the clinical course of both children and adults with CF, impacting the quality of life and disease prognosis, suggesting that their routine assessment should be incorporated into the clinical evaluation of patients from the first stages of the disease regardless of suggestive symptoms, in order to avoid late diagnosis. Finally, although the prevalence of SDB in patients with mycobacterial infections is uncertain, extrapulmonary manifestations, particularly nasopharyngeal locations, and concomitant symptoms, such as body pain and depression, may act as atypical predisposing factors for their development.

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Section: Sleep-disordered Breathing and Bronchiectasismentioning

confidence: 99%

Section: Sleep-disordered Breathing and Bronchiectasismentioning

confidence: 99%

Section: Sleep-disordered Breathing and Bronchiectasismentioning

confidence: 99%

Section: Sleep-disordered Breathing and Bronchiectasismentioning

confidence: 99%

See 2 more Smart Citations

Sleep-Disordered Breathing and Chronic Respiratory Infections: A Narrative Review in Adult and Pediatric Population

Faverio

Zanini

Monzani

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Bronchiectasis refers to irreversible damage and dilation of the airways, leading to impaired mucociliary clearance, chronic productive cough, and increased susceptibility to pulmonary infections. Although bronchiectasis is a less common disease than asthma and COPD, it has also been associated with OSA at roughly twice the expected rate [48][49][50]. Airway collapse and reopening during intrathoracic pressure swings may perpetuate the vicious cycle thought to cause bronchiectasis [51].…”

Section: Osa and Other Airway Disordersmentioning

confidence: 99%

OSA and Chronic Respiratory Disease: Mechanisms and Epidemiology

Locke

Lee

Sundar

2022

IJERPH

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Obstructive sleep apnea (OSA) is a highly prevalent disorder that has profound implications on the outcomes of patients with chronic lung disease. The hallmark of OSA is a collapse of the oropharynx resulting in a transient reduction in airflow, large intrathoracic pressure swings, and intermittent hypoxia and hypercapnia. The subsequent cytokine-mediated inflammatory cascade, coupled with tractional lung injury, damages the lungs and may worsen several conditions, including chronic obstructive pulmonary disease, asthma, interstitial lung disease, and pulmonary hypertension. Further complicating this is the sleep fragmentation and deterioration of sleep quality that occurs because of OSA, which can compound the fatigue and physical exhaustion often experienced by patients due to their chronic lung disease. For patients with many pulmonary disorders, the available evidence suggests that the prompt recognition and treatment of sleep-disordered breathing improves their quality of life and may also alter the course of their illness. However, more robust studies are needed to truly understand this relationship and the impacts of confounding comorbidities such as obesity and gastroesophageal reflux disease. Clinicians taking care of patients with chronic pulmonary disease should screen and treat patients for OSA, given the complex bidirectional relationship OSA has with chronic lung disease.

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