2011
DOI: 10.1001/archinternmed.2011.295
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The Frequency of Medical Reversal

Abstract: The Frequency of Medical Reversal W e use the term reversal to signify the phenomenon of a new trial-superior to predecessors because of better design, increased power, or more appropriate controls-contradicting current clinical practice. In recent years, a number of such reversals have occurred. Use of hormone therapy, 1 the class 1C antiarrhythmic agents, 2 and the pulmonary artery catheter 3 have decreased when trials demonstrated that they are either less effective than previously thought or harmful. Rever… Show more

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Cited by 118 publications
(100 citation statements)
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“…Between 30% and 50% of contemporary trials that test established practices show that the practices confer little or no benefit, in contradiction to prevailing assumptions. 22 Examples include percutaneous coronary artery intervention in stable, non-critical coronary artery disease, 23 facility-based cardiac rehabilitation programs following myocardial infarction, 24 vertebroplasty for acute osteoporotic fracture 25 and blood glucose self-monitoring in stable type 2 diabetes. 26 Such discredited practices tend to persist, often for years, 27 sustained sometimes by vested commercial interests, but more often by strongly held professional beliefs.…”
Section: Minimise Errors In Diagnosismentioning
confidence: 99%
“…Between 30% and 50% of contemporary trials that test established practices show that the practices confer little or no benefit, in contradiction to prevailing assumptions. 22 Examples include percutaneous coronary artery intervention in stable, non-critical coronary artery disease, 23 facility-based cardiac rehabilitation programs following myocardial infarction, 24 vertebroplasty for acute osteoporotic fracture 25 and blood glucose self-monitoring in stable type 2 diabetes. 26 Such discredited practices tend to persist, often for years, 27 sustained sometimes by vested commercial interests, but more often by strongly held professional beliefs.…”
Section: Minimise Errors In Diagnosismentioning
confidence: 99%
“…The facility of adequate disposable sets for drainage is the counterpart of the easy-to-get US machines, equipped with reliable and suitable convex and linear probes, and set appropriately for superficial and lung imaging. The traps, in these conditions, are not many and the only risky trap is, as above addressed, over-trusting in US criteria not evidencebased and, more important, which are demonstrated to be unreliable when critically re-appraised; reversal of such scarcely validated but recommended practices, which could be harmful for patients, is actively in progress (32,33) also in this field of medicine.…”
Section: Final Recommendationmentioning
confidence: 99%
“…Prasad reviewed all articles in the 2009 New England Journal of Medicine that made a claim about a medical practice. 18 The articles were divided equally between those that constituted a reversal, those that upheld an existing practice as beneficial, and those that were inconclusive regarding a current practice. Once incorrect findings from earlier studies are refuted by better quality data, it is not a given that they fade into oblivion accompanied by the practices that they supported.…”
Section: Principal Findings -Literature Searchmentioning
confidence: 99%