The frequency of lung cancer in patients with pulmonary hamartomas: An evaluation of clinical, radiological, and pathological features and follow-up data of 96 patients with pulmonary hamartomas

Ekinci, Gulbanu Horzum; Haciomeroglu, Osman; Ersev, Ayşe; Alpay, Levent; Özgen, Hasan; Yilmaz, Abdurrahman

doi:10.1016/j.rppnen.2017.04.008

Cited by 9 publications

(13 citation statements)

References 20 publications

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“…Thus, an incomplete excision likely explained this event. Previously published series in the English literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16], considered collectively with the present in Table 4, con rmed our results. Among 1,733 patients evaluated, recurrence after excision was found in only 4 cases (0.23%).…”

Section: Discussionsupporting

confidence: 86%

“…Third, we found that PH was associated with synchronous or metachronous lung cancer in 14% of our population that is likely higher compared to the incidence of lung cancer in general Italian population considering that about 41,500 new cases of lung cancer have been estimated in 2018 as reported by the Italian Association of Medical Oncology and the Italian Association of Tumor Registries [24]. The association between PH and lung cancer has been previously reported, with an incidence ranging from 1-23% in previous studies [1][2][3][4][5][6][7][8][9]15], summarized in Table 5. Furthermore, Karasik et al [2], and Ribet et al…”

Section: Discussionmentioning

confidence: 94%

“…Generally, PH presents as a peripheral intraparenchymal solitary nodule incidentally detected during assessments for other diseases [10][11][12]. Despite the advancement in medical imaging and therapy, surgical resection remains the option of choice for diagnostic and therapeutic purposes [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study

Fiorelli

D’Andrilli

Carlucci

et al. 2021

Preprint

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PURPOSEPulmonary hamartoma is the most common benign tumor of the lung. We analyzed a 20-year historical series of patients with pulmonary hamartoma undergoing surgical resection, aiming to evaluate the characteristics, the outcomes, and the association between hamartoma and lung cancer. METHODSIt was a retrospective multicenter study including the data of all consecutive patients with pulmonary hamartoma undergoing surgical resection. The end-points were to evaluate: i) the characteristics of hamartoma, ii) outcomes, iii) whether hamartoma was a predictive factor for lung cancer development RESULTSOur study population included 540 patients. Upfront surgical or endoscopic resection was performed in 385 (71%) cases while in the remaining 155 (29%) cases, the lesions were resected 20±3.5 months after diagnosis due to increase in size. In most cases, lung sparing resection was carried out including enucleation (n=259; 48%) and wedge resection (n=230; 43%) while 5 (1%) patients underwent endoscopic resection. Only two patients (0,2%) had major complications. One patient (0.23%) had recurrence after endoscopic resection, while no cases of malignant degeneration were seen (mean follow-up: 103.3±93 months). Seventy-six patients (14%) had associated lung cancer, synchronous in 9 (12%) and metachronous in 67 (88%). Only age > 70-year-old (p=0.0059) and smokers >20 cigarettes/day (p<0.0001) were the significant risk factors for cancer development on logistic regression analysis. CONCLUSIONSSurgical resection of hamartoma is a safe procedure; recurrence and malignant degeneration are very uncommon and the association between hamartoma and lung cancer seems to be a spurious phenomenon.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study

Fiorelli

D’Andrilli

Carlucci

et al. 2021

Preprint

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show abstract

“…Pulmonary hamartomas are the most frequently diagnosed benign lung tumors that affect 2-4 times more commonly males than females. Most cases are observed in patients between 40 and 70 years of age 4 . In our series the male to female ratio was 1.4, and the mean age of the patients was 50.6 years.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary hamartoma: Retrospective analysis of 24 cases

Haberal¹,

Dikiş²,

Akar³

2019

Dicle Tıp Dergisi

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Objective: Lung hamartoma is the most frequently diagnosed benign lung tumor. The aim of this study was to investigate the clinical, radiological and pathological data of the patients with pulmonary hamartoma who underwent surgical treatment in our clinic. Methods: Hospital records of 24 lung hamartoma patients given surgical treatment in our clinics between January 2005 and December 2017 were investigated retrospectively. In this study, these cases were evaluated with respect to age, gender, clinical, histopathological, and radiological features, and surgical methods. Results: There were 24 patients with a mean age of 50.6 (23-66) years, consisting of 14 males and 10 females, who underwent surgical resection for pulmonary hamartoma was. While 17 (42%) patients were asymptomatic, the rest complained of coughing, shortness of breath and repetitive lung infections. Hamartoma was localized in the right lung in 16 (67%) of the cases; peripherally in 17 (71%), and centrally in 7 (29%). All patients underwent wedge resection, 17 cases by thoracoscopy and 7 cases by thoracotomy. The mean tumor diameter assessed macroscopically was 2.9 cm (1-4.5cm). Conclusion: Pulmonary hamartomas frequently present as peripheral solitary nodules. Given its low morbidity and mortality, surgical resection is recommended for definitive diagnosis and treatment, the objective of the intervention being total excision of the lesion while protecting the lung parenchyma.

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“…Despite having a very low malignant potential, systemic workup and diagnosis are necessary, as bronchogenic carcinoma must be ruled out 10. Studies have demonstrated that hamartomas have an association with malignant lung tumours and are reported to have presented with synchronous and metachronous lung cancers 11…”

Section: Discussionmentioning

confidence: 99%

Incidental endobronchial hamartoma in a patient with enchondroma

Syriac¹,

Bhaskarla

Elrifai

et al. 2019

BMJ Case Rep

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Hamartomas are the most common type of benign tumours of the lung, constituting a small portion of all lung neoplasms. Hamartomas are rare benign tumours composed of multiple mesenchymal cell lines. Two clinical types have been defined according to the location: intraparenchymal and endobronchial, more frequently the former. We present a case of endobronchial hamartoma causing significant blockage of the right middle lobe. The finding was incidental on a CT scan of the chest done for staging purposes for a large mixed lytic and sclerotic lesion that was found within the proximal-mid portion of the tibial diaphysis. The endobronchial lesion was removed by hot electrocautery snare during bronchoscopy and identified as a hamartoma. Argon plasma coagulation was applied to the lesion’s base afterwards and the patient was to follow-up in 3 months for a repeat CT scan.

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The frequency of lung cancer in patients with pulmonary hamartomas: An evaluation of clinical, radiological, and pathological features and follow-up data of 96 patients with pulmonary hamartomas

Abstract: Our results show that patients with pulmonary hamartomas may have coexisting lung malignancies.

Cited by 9 publications

References 20 publications

Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study

Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study

Pulmonary hamartoma: Retrospective analysis of 24 cases

Incidental endobronchial hamartoma in a patient with enchondroma

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