The Frequency of Glucose-6-Phosphate Dehydrogenase Phenotypes and Sickle Cell Genes in Al-Qatif Oasis

El‐Hazmi, Mohsen A. F.; Warsy, Arjumand S.

doi:10.5144/0256-4947.1994.491

Cited by 10 publications

(6 citation statements)

References 21 publications

(33 reference statements)

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“…The high frequency of G6PD deficiency (11.61 %) in malaria endemic populations of Cameroon corroborates the role malaria play in the distribution of G6PD genes in most malaria endemic areas in the world (El-Hazmi and Warsy, 1994). The percentage gene frequencies for G6PD deficiency of hemizygous males were computed to be 9.21 % and 10.85 % for the NW and SW populations respectively.…”

Section: Discussionsupporting

confidence: 58%

Prevalence Of Sickle Haemoglobin And Glucose–6–Phosphate Dehydrogenase Deficiency Genes In The Populations Of North West And South West Provinces, Cameroon

Uzoegwu¹,

Awah²

2008

Anim. Res. Int.

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Hereditary disorders of erythrocytes are common in many areas of the world, including Cameroon Limited knowledge on the consequences of high incidences of sickle haemoglobin (HbS) and glucose-6-phosphate dehydrogenase (G6PD) deficiency genes in the Cameroons might have been responsible for the haemoglobin genotype mismatched marriages among the sickle heterozygotes and drug-induced anaemia among the G6PD deficient individuals ignorantly treated w th oxidant drugs having high redox potential. The situation therefore, informed the random screening of the populace of the North West and South West populat ons of Cameroon for these genes w th a view not only to reveal their current incidences and level of interaction but also to educate the people on the consequences of these genetic defects. Our results revealed the total incidences of 32.20 % sickle and 11 61 % G6PD deficiency genes. The percentage frequency of the sickle cell gene was higher in the South western (18 80 %) than in the North West (14 51 %) populations. The percentage incidence o G6PD deficiency was 9 21 % and 1 20 % for males and females respect vely in the North West and 10.85 % and 1.46 % for males and females respectively in the South West. The interaction was not s gnificant (P > 0.01) between G6PD deficiency and HbS for the North West and South West populat ons. These genetic defects must have reached polymorphic levels due to natural selection through survival advantage against death from malaria and consanguineous marriages. .

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Section: Discussionsupporting

confidence: 58%

Prevalence Of Sickle Haemoglobin And Glucose–6–Phosphate Dehydrogenase Deficiency Genes In The Populations Of North West And South West Provinces, Cameroon

Uzoegwu¹,

Awah²

2008

Anim. Res. Int.

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“…The possible protective mechanism of this protection was investigated in the population of Bamenda district of Cameroon which was earlier revealed to have malaria prevalence of 42.2%, most of the plasmodial infection (93.7%) being caused by Plasmodium falciparum (Awah & Uzoegwu, 2007). The 10.4% incidence of G6PD deficiency gene screened for this population during this study is similar to most of the incidences reported for most of the malaria endemic areas of the world (El-Hazmi & Warsy, 1994;Allison, 2004). Our major observation in this study that G6PD nondeficient individuals were more vulnerable to malaria disease and subsequently exhibited more severe malarial anaemia and symptoms, higher parasite density, more frequency of plasmodial attack and lower Hb concentration during plasmodial infection than the enzyme deficient cohorts seem to support the hypothesis that this enzyme deficiency might have arisen in a bid to fight against falciparum malaria (Kar et al, 1990).…”

Section: Discussionsupporting

confidence: 60%

Malaria Protection In Glucose-6-Phosphate Dehydrogenase Deficient Individuals In Bamenda Population Of Cameroon

Awah¹,

Uzoegwu²

2008

Glo Jnl Pure Appl Sci

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The high frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency gene in malaria endemic regions is believed to be due to the enzyme deficiency advantage against fatal malaria. However, the mechanism of this protection is not well understood and therefore was investigated by comparing differences in plasmodial parasitaemia, full blood count profile and the severity of clinical malarial symptoms of G6PD deficient and G6PD non-deficient cohort groups in the population. Our results showed that 10.4% (63/606) of those tested carried the G6PD deficiency gene. G6PD deficient heterozygous females and hemizygous males manifested significantly reduced (P<0.05) parasitaemia, less severe malarial anaemia, less severe clinical malarial symptoms and elevated haematological profile during the progress of malaria when compared with G6PD non-deficient subjects. The results seem to suggest that G6PD deficiency gene could be among the factors that confer malaria protection in the hosts through reduction of severe malarial anaemia, density parasitaemia and clinical malarial symptoms while having less effect on frequency of infection perse.

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“…The 0.1% incidence rate of SCD and other Hb variant disease in the Lebanese population is higher than the UAE (0.67%) and lower than the Eastern provinces of Saudi Arabia (3.8%) [11], [14], [21], [22]. Compared to other Arab countries such as Libya (0.37%), Yemen (0.9%), and Bahrain (0.6–2.1%), the incidence of the disease in Lebanon is relatively low.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Sickle Cell Disease and Other Hemoglobin Variants in 10,095 Lebanese Neonates

et al. 2014

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Hemoglobinopathies are highly prevalent diseases and impose a public health burden. Early diagnosis and treatment can ameliorate the course of these diseases and improve survival. Despite purported high incidence of hemoglobinopathies in Lebanon, there are no nationwide screening programs. In this study, newborn screening utilizing high pressure liquid chromatography was executed in all public hospitals across Lebanon between 2010 and 2013. All newborns with an abnormal hemoglobin (Hb) were offered genetic counseling and all those with disease were enrolled in comprehensive hemoglobinopathy clinics. Among newborns, 2.1% were found to have an abnormal Hb variant with sickle Hb being the most common while 0.1% were found to have sickle cell disease (SCD). The majority of those with SCD had non-Lebanese origins. The most common causes of hospitalizations in infants with SCD were acute splenic sequestration and pain crises. No bacteremia or other life threatening infections were noted. At a median follow up 14 months (follow up range 7 to 34 months), all children with disease are alive and compliant with treatment. Systematic screening for SCD and other Hb variants was shown to be feasible, cost effective, and of accurate predictive value. This program was also clinically effective because it led to the identification of babies with disease and to providing them with free early multidisciplinary care. Conclusively, a newborn screening program should be implemented across Lebanon to detect hemoglobinopathies and initiate early therapeutic and preventive strategies and genetic counseling.

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The Frequency of Glucose-6-Phosphate Dehydrogenase Phenotypes and Sickle Cell Genes in Al-Qatif Oasis

Cited by 10 publications

References 21 publications

Prevalence Of Sickle Haemoglobin And Glucose–6–Phosphate Dehydrogenase Deficiency Genes In The Populations Of North West And South West Provinces, Cameroon

Prevalence Of Sickle Haemoglobin And Glucose–6–Phosphate Dehydrogenase Deficiency Genes In The Populations Of North West And South West Provinces, Cameroon

Malaria Protection In Glucose-6-Phosphate Dehydrogenase Deficient Individuals In Bamenda Population Of Cameroon

Incidence of Sickle Cell Disease and Other Hemoglobin Variants in 10,095 Lebanese Neonates

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