The frequency of feto-maternal complications in patients with intrahepatic cholestasis of pregnancy.

Abstract

Objective: To determine the frequency of complications in patients with intrahepatic cholestasis of pregnancy. Study Design: Descriptive Case Series. Setting: Department of Obstetrics & Gynecology, Shahida Islam Medical College, Lodhran. Period: July 2019 to December 2020. Material & Methods: A total of 141 patients with intrahepatic cholestasis of pregnancy of age 18 to 40 years were included. Patients with multiple pregnancies, history of alcohol intake, CR and preexisting chronic liver disease were excluded. All women were followed till delivery (gestational age ≤ 41 weeks) and feto-maternal outcome i.e. postpartum hemorrhage, cesarean section, APGAR score <7 at 5 minutes, low birth weight, prematurity, meconium stained liquor and intrauterine fetal death (yes/no) was noted. Results: Feto-maternal outcome was as follows; postpartum hemorrhage in 18 (12.77%), cesarean section in 47 (33.33%), preterm birth in 34 (24.11%), APGAR score <7 at five minutes in 13 (9.22%), meconium stained liquor in 45 (31.91%) patients, low birth weight in 14 (9.93%) and Intra-uterine fetal death in 11 (7.80%) patients. Conclusion: Our study concluded that we should develop some serious recommendations for these high risk patients in our routine practice. It will reduce the morbidity and mortality related to this high risk condition.

Outcomes of liver diseases in pregnant females: A study from a tertiary care medical center in Pakistan

“…In comparison, the highest peaks are reported from the South American countries and Scandinavia (28%). 1,[2][3][4][5] While HELLP syndrome is a rare variant of severe PEC, around 12% of these patients suffer from HELLP syndrome. 6 Another rare condition, AFLP complicating the third trimester, affects one in every 16,000 pregnancies.…”