The frequency of aspirin resistance by a modified thrombelastography method and its relationship with clinical and laboratory parameters in patients with stable coronary artery disease

Şahin, Durmuş Yıldıray; Koç, Mevlüt; Çaylı, Murat; Uysal, Onur Kadir; Karaarslan, Osman; Kanadaşı, Mehmet; Demirtaş, Mustafa

doi:10.5543/tkda.2012.01645

Cited by 3 publications

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“…In recent studies, the relationship between prothrombotic variables and aspirin resistance has been examined. The results of these studies revealed that the fibrinogen level and platelet count were high in patients with aspirin resistance (17,30). In the present study, when the cut-off value was 287.5 for the fibrinogen level, the sensitivity was 86.8%, and the specificity was 72.3% (Figure 1).…”

Section: Discussionsupporting

confidence: 51%

Aspirin Resistance in Children with Congenital Heart Disease and Its Relationship with Laboratory and Clinical Parameters

et al. 2021

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Background: Patients with congenital heart disease (CHD) are more prone to thromboembolism. Aspirin is the most commonly used medication around the world to prevent thrombosis in cardiovascular diseases. Objectives: This study aimed to define the frequency of aspirin resistance in pediatric patients with CHD and to evaluate the correlation of clinical and laboratory parameters with aspirin resistance. Methods: The study population consisted of 103 patients using aspirin, including 53 cases of cyanotic CHD and 50 cases of non-cyanotic CHD. Platelet aggregation was measured by the AggreGuide A-100 ADP Assay. Results: The prevalence of aspirin resistance was 36.9% in children with CHD. Although aspirin resistance in cyanotic CHD patients (41.5%) was higher than in non-cyanotic patients (32%), the difference was not statistically significant (P = 0.414). There was no significant association between aspirin responsiveness or resistance and the patient’s sex, age, duration of aspirin use, and concomitant medication use. Comparison of the laboratory data of aspirin-responsive and -resistant patients showed no significant difference between these groups, except for albumin (P = 0.032) and serum fibrinogen (P = 0.0001) levels. The fibrinogen level and thromboembolism history were independent risk factors for aspirin resistance. Also, there was a significant correlation between platelet aggregation in peripheral blood smears and aspirin resistance (P = 0.0001). Conclusions: Our findings suggest that measurement of the serum fibrinogen level and platelet aggregation in blood smears may be the first step to predict aspirin resistance.

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Section: Discussionsupporting

confidence: 51%

Aspirin Resistance in Children with Congenital Heart Disease and Its Relationship with Laboratory and Clinical Parameters

et al. 2021

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“…Bazı çalışmalarda bu ilişkinin izlenememesinin, daha hassas bir yöntemin kullanılmamasına bağlı olduğu düşünüldü. 61 Bu bulgular, ölçümü kolay bir biyokimyasal ve muayene yöntemi olan fibrinojen ve hsCRP ile, aspirin direncini öngör-meye başvurulabileceğini düşündürmektedir. Bu sonuçların klinik pratikte hasta takibinde göz önünde bulundurulmasında yarar olabilir.…”

Section: Aspi̇ri̇n Di̇renci̇ Ve Di̇ğer Deği̇şkenler Arasindaki̇ İli̇şki̇unclassified

The Frequency of Aspirin Resistance and Its Relationship with Clinical and Laboratory Parameters in Patients with Stable Coronary Artery Disease

Tekkeşin¹,

Ardal²,

Tetik³

2014

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Aspirin, kardiyovasküler tıpta antitrombosit tedavinin temelini oluşturur. Aspirin ile yetersiz trombosit baskılanması sonucu aspirine dirençli tanımlanan koroner arter hastalarında (KAH), kardiyovasküler olaylardan zarar görme riski yüksek olabilir. Dolayısıyla, trombosit fonksiyonlarını ölçerek bu hastaların belirlenmesi büyük önem taşımaktadır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmanın amacı, 100 mg/gün aspirin kullanan stabil KAH'ı olan 123 hastada (69 erkek, 54 bayan; ortalama yaş±SS: 56±0,8 yıl) referans bir metot kullanarak aspirin direncinin frekansını ve klinik ve biyokimyasal parametreler ile ilişkisini araştırmaktı. Aspirin cevabı, hızlı bir araç, hasta başı metot olan VerifyNow testi ile belirlendi, ve aspirin direnci araşidonik asit ile uyarılan trombosit agregasyon hızının 550 ARU (aspirin reaction unit)'nun üzerinde olması diye tanım-landı. B Bu ul lg gu ul la ar r: : Otuz bir hastada aspirin direnci saptandı (%25,2). Aspirin direnci ile hipertansif ve sigara içen hastalar arasında belirgin bir ilişki saptandı. Aspirine dirençli olan hastalarda hassas olanlara göre fibrinojen ve hsCRP (hassas CRP) düzeyleri anlamlı düzeyde yüksekti (fibrinojen: dirençli 748±67,8 mg/dL, hassas 347±41.9 mg/dL, hsCRP: dirençli 8.7±1.8 mg/L, hassas 3.2±0.9 mg/L, p <0,0001). Lipidler dışında diğer laboratuvar parametrelerinin hiçbiri, aspirine dirençli ve hassas olan hastalar arasında farklı değildi. S So on nu uç ç: : Bulgularımıza göre aspirin direncini belirlemede ilk adım olarak fibrinojen ve hsCRP düzeylerinin ölçümünün kullanılabileceği önerilmektedir. Bununla birlikte aspirin direnci olan hastalarda antitrombosit tedaviyi optimize edebilmek üzere major kardiyovasküler olayların riskini belirlemek için daha ileri çalışmalara ihtiyacımız vardır.A An na ah ht ta ar r K Ke el li im me el le er r: : Aspirin; trombosit agregasyon inhibitörleri; fibrinojen; koroner arter hastalığı A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Aspirin is the cornerstone of antiplatelet therapy in cardiovascular medicine. Patients with coronary artery disease (CAD) with inadequate platelet inhibition by aspirin, referred to as aspirin resistance, might have an increased risk of suffering cardiovascular events. Therefore, identification of these patients by measuring platelet function is of great importance. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The aim of this study was to investigate the frequency of aspirin resistance using a reference method and related clinical and biochemical parameters in 123 patients (69 males, 54 females; mean age±SD: 56±0.8 years) with stable coronary artery disease (CAD), who received 100 mg/day aspirin. Aspirin responsiveness was determined using a rapid tool, point-of-care (POC) method, VerifyNow assay, and resistance was defined as arachidonic acid-induced platelet aggregation rate above 550 ARU (aspirin reaction unit). R Re es su ul lt ts s: : Aspirin resistance was detected in 31 patients (25.2%). A significant relation ...

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Aspirin response variability after major orthopedic surgery

Li¹,

Hirsh²,

Sloane³

et al. 2012

Thrombosis Research

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The frequency of aspirin resistance by a modified thrombelastography method and its relationship with clinical and laboratory parameters in patients with stable coronary artery disease

Abstract: Our findings suggest that measurements of fibrinogen level and pulse pressure may be used as easy and reliable methods in predicting aspirin resistance.

Cited by 3 publications

References 0 publications

Aspirin Resistance in Children with Congenital Heart Disease and Its Relationship with Laboratory and Clinical Parameters

Aspirin Resistance in Children with Congenital Heart Disease and Its Relationship with Laboratory and Clinical Parameters

The Frequency of Aspirin Resistance and Its Relationship with Clinical and Laboratory Parameters in Patients with Stable Coronary Artery Disease

Aspirin response variability after major orthopedic surgery

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