The frequency of adverse drug reaction related admissions according to method of detection, admission urgency and medical department specialty

Brvar, Miran; Fokter, Nina; Bunc, Matjaž; Možina, Martin

doi:10.1186/1472-6904-9-8

Cited by 94 publications

(84 citation statements)

References 28 publications

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“…Moreover, in general, adverse drug reactions are poorly reported [11][12][13]. These results are consistent with those of the current study, as no side effects were observed in our sample of 134 patients.…”

Section: Doi: 107243/2053-5775-1-4supporting

confidence: 83%

Oral surgical procedures and pain, postoperative after use the ibuprofen or acetaminophen

Semenoff-Segundo¹,

Matos²,

Porto³

et al. 2013

Oral Biol Dent

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Aim: The aim of this study was to compare the effects of anti-inflammatory (ibuprofen, 600 mg) and analgesic (Acetaminophen, 750 mg) drugs on postoperative pain. Material and methods: Patients with indications for surgery were selected, and a total of 57 patients, 20 male (35.1%) and 37 female (64.9%) were included in the study. Of these, 26 patients were placed in the acetaminophen group, and 31 were placed in the ibuprofen group. The average age of the patients was 30 years. The following types of surgeries were included in the evaluation: clinical crown lengthening, gingivectomy, pre-prosthetic surgery, labial frenum and frenum lingual. The surgeries were performed by students in a postgraduate training program in periodontics. Subsequent surgery, postoperative period orientations were provided by the researcher, and the medication to be prescribed was selected at random allocation. Both medications were administered for 48-h periods. A visual analogue scale with values ranging from 0 to 10, where 0 represented no pain and 10 represented maximum pain, was provided to the patients, and the patients were asked to rate their pain using this scale each time they took the medication. At the time of the follow-up visit, the patient data were given to the researcher and subsequently tabulated and applied to the statistical analysis (Mann-Whitney, p<0.05). Results:The results showed no significant difference in pain between medications (p>0.05). Conclusions: There was no difference in postoperative periodontal surgery pain after the use of anti-inflammatory or analgesic drugs.

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Section: Doi: 107243/2053-5775-1-4supporting

confidence: 83%

Oral surgical procedures and pain, postoperative after use the ibuprofen or acetaminophen

Semenoff-Segundo¹,

Matos²,

Porto³

et al. 2013

Oral Biol Dent

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“…4 Cerca de 5% das admissões hospitalares deve-se a iatrogenia medicamentosa. [5][6][7] A incidência de eventos adversos varia de acordo com a faixa etária. A proporção de idosos que é admitida a nível hospitalar devido a iatrogenia medicamentosa é superior comparativamente à estimada para os outros doentes adultos e para as crianças (10,7% vs. 6,3% vs. 4,1%, respetivamente).…”

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Farmacovigilância em Portugal: Atividade da Unidade Regional do Centro

et al. 2015

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Introduction:The aim of this study was to characterize the spontaneous reports of adverse events that were received by the Central Portugal Regional Pharmacovigilance Unit. Material and Methods: Spontaneous reports received between 01/2001 and 12/2013 were considered. The annual reporting ratios were estimated. The cases were characterized according to their seriousness, previous description, causality assessment, origin and professional group of the reporter, type of adverse event and pharmacotherapeutic groups of the suspected drugs most frequently reported. Results:The Pharmacovigilance Unit received 2408 reports that contained 5749 adverse events. In 2013, the reporting rate was estimated at 171 reports per million inhabitants. Fifty-five percent of the reports were assessed as serious. Ninety percent of the cases were assessed as being at least possibly related with the suspected drug. The suspected drugs most frequently reported were antiinfectives for systemic use (n = 809, 33%). The most frequently reported adverse events were "Skin and subcutaneous tissue disorders" (n = 1139, 20%). There were 154 (6.4%) reports resulting in life-threatening situations and/or death, and 88 (3.6%) containing at least one adverse event assessed as serious, unknown and certain or probable. Discussion: The present results are in line with those found in other studies, namely the seriousness and type of the adverse events and the pharmacotherapeutic groups of the most frequently reported suspected drugs. Conclusion:In the last years, the Central Portugal Regional Pharmacovigilance Unit has registered a growth in the reporting rate in general, as well as an increase in the reporting of unknown and serious adverse drug reactions.

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“…Higher prevalence of serious ADEs in 20-40 years age group was also seen in a study by Naveen, et al 13 Male preponderance was observed in the present study, (74%) which was much higher as compared to other studies from Miran Brvar et al from Slovenia in which males constituted 57% of the patients with serious ADEs. 14 In the present study, serious ADEs were caused mainly by Anti epileptic drugs (AED) (32%) followed by Anti HIV drugs and Anti tubercular drugs (18% each). This is in contrast with another study by Pirmohamed et al who reported that NSAIDS (29.6%) followed by diuretics (27.3%) were the major causative drugs for serious ADEs.…”

Section: Discussionmentioning

confidence: 99%

Profile of serious adverse drug events in a tertiary care hospital of South India - a five years experience

Jayanthi

Pasha

Sushma

2017

Int J Basic Clin Pharmacol

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Background: Adverse drug event (ADE) is said to be serious, when it is life-threatening, leads to hospitalization, disability, congenital anomaly, death or requires intervention to prevent permanent impairment or damage. The present study aimed to determine the pattern, causality, preventability of serious ADEs.Methods: This retrospective study was carried out to profile serious ADEs reported from Bangalore Medical College and Research Institute to Adverse Drug Reaction (ADR) Monitoring Centre, under Pharmacovigilance Programme of India from 2012 to 2016. Patient demographics, clinical and drug data, details of the ADE, onset time, causal drug details, outcome and severity were collected as per CDSCO form. Causality was assessed by WHO-ADR probability scale, preventability by modified Schumock and Thornton scale.Results: A total of 809 ADEs were reported, of which 50 (6.18%) were serious in nature. Male preponderance (74%) was observed, with 42% among patients aged 20-40 years. 56% of serious ADEs were reported from department of Dermatology. Steven Johnson Syndrome (SJS) (20%) contributed for most of the ADEs. Antiepileptics caused maximum number of serious ADEs (32%). 76% of the ADEs were found to be ‘probable’ and 4% were definitely preventable. 56% of them was life threatening and 86% required intensive interventions. 16% patients experienced serious ADEs during hospital stay.Conclusions: Serious ADEs constituted 6.18% of all ADEs reported. SJS was commonly seen with antimicrobials and hepatotoxicity with ATT. Antiepileptics and ATT contributed for majority of them. This study highlights the importance of monitoring and timely management of serious ADEs to commonly prescribed medications.

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The frequency of adverse drug reaction related admissions according to method of detection, admission urgency and medical department specialty

Cited by 94 publications

References 28 publications

Oral surgical procedures and pain, postoperative after use the ibuprofen or acetaminophen

Oral surgical procedures and pain, postoperative after use the ibuprofen or acetaminophen

Farmacovigilância em Portugal: Atividade da Unidade Regional do Centro

Profile of serious adverse drug events in a tertiary care hospital of South India - a five years experience

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